Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Maria C. Edman"'
Autor:
Shruti Singh Kakan, Maria C. Edman, Alexander Yao, Curtis T. Okamoto, Annie Nguyen, Brooke E. Hjelm, Sarah F. Hamm-Alvarez
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveThe tear miRNAome of the male NOD mouse, a model of ocular symptoms of Sjögren’s syndrome (SS), was analyzed to identify unique miRNAs.MethodsMale NOD mice, aged 12-14 weeks, were used to identify tear miRNAs associated with development o
Externí odkaz:
https://doaj.org/article/bbaadbfae67f43d9aaa6d23da6dc160f
Autor:
Shruti Singh Kakan, Srikanth R. Janga, Benjamin Cooperman, David W. Craig, Maria C. Edman, Curtis T. Okamoto, Sarah F. Hamm-Alvarez
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Sjögren's Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and loss of function of moisture-producing exocrine glands as well as systemic inflammation. SS diagnosis is cumbersome, subjective and complicated by manifes
Externí odkaz:
https://doaj.org/article/ed6b44977119476fa0486eb2a54f5bdd
Autor:
Hema S. Aluri, Mahta Samizadeh, Maria C. Edman, Dillon R. Hawley, Helene L. Armaos, Srikanth R. Janga, Zhen Meng, Victor G. Sendra, Pedram Hamrah, Claire L. Kublin, Sarah F. Hamm-Alvarez, Driss Zoukhri
Publikováno v:
Stem Cells International, Vol 2017 (2017)
The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren’s syndrome dry eye and to investigate the underlying mechanisms invol
Externí odkaz:
https://doaj.org/article/296f6e8165284da1b59016931fdb8ec7
Autor:
Shruti Singh Kakan, Xiaoyang Li, Maria C. Edman, Curtis T. Okamoto, Brooke E. Hjelm, Sarah F. Hamm-Alvarez
Publikováno v:
Investigative Opthalmology & Visual Science. 64:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40c2456ffad5ff0c4ab8695cce5f265
https://doi.org/10.1167/iovs.64.4.1
https://doi.org/10.1167/iovs.64.4.1
Publikováno v:
Eye Contact Lens
Tears are highly concentrated in proteins relative to other biofluids, and a notable fraction of tear proteins are proteases and protease inhibitors. These components are present in a delicate equilibrium that maintains ocular surface homeostasis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c34cac3b8e263f6a7d61cd92037f96
https://doi.org/10.1097/icl.0000000000000641
https://doi.org/10.1097/icl.0000000000000641
Autor:
Hao Guo, Yaping Ju, Minchang Choi, Maria C. Edman, Stan G. Louie, Sarah F. Hamm-Alvarez, J. Andrew MacKay
Publikováno v:
Biomaterials
Sjögren’s syndrome (SS) is a multifactorial autoimmune disease with principal symptoms including inflammation and loss of function of lacrimal glands (LG) and salivary glands. While glandular infiltrates includes both B- and T- cells, CD4+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb5925dadd931d04d960f28636b8f6d
https://europepmc.org/articles/PMC8982551/
https://europepmc.org/articles/PMC8982551/
Autor:
Mark F. Lew, Sarah F. Hamm-Alvarez, Srikanth Reddy Janga, Maria C. Edman, Danielle Feigenbaum, Wendy J. Mack, Daniel Freire, Curtis T. Okamoto
Publikováno v:
Biomarkers in Medicine. 13:1447-1457
Aim: Due to active engagement of sensory and afferent nerve fibers in reflex tearing which could be affected in Parkinson's disease (PD), we tested reflex tears as a source of potential PD biomarkers. Patients & methods: Reflex tears collected from 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d121ac1ce87a237b3e0233036fbab4a
https://doi.org/10.2217/bmm-2019-0315
https://doi.org/10.2217/bmm-2019-0315
Autor:
Sarah F. Hamm-Alvarez, Alexander Yao, Maria C. Edman, Shruti Singh Kakan, Brooke E. Hjelm, Curtis T. Okamoto
ObjectiveThe tear miRNAome of the male NOD mouse, a model of ocular symptoms of Sjögren’s syndrome (SS), was analyzed to identify possible tear biomarkers of the disease.MethodsMale NOD mice, aged 12-14 weeks, were used to identify tear miRNAs ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d36c548cef34d96136904c51da9bfa
https://doi.org/10.1101/2021.10.10.463771
https://doi.org/10.1101/2021.10.10.463771
Autor:
Srikanth Reddy Janga, Sarah F. Hamm-Alvarez, Raveena Ghanshani, Wendy J. Mack, Daniel Freire, Danielle Feigenbaum, Mark F. Lew, Maria C. Edman, Curtis T. Okamoto, Mihir Shah
Publikováno v:
Biomarkers in Medicine. 13:941-952
Aim: Secretion of proteins into basal tears of Parkinson’s disease (PD) patients may be altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total α-SynTotal, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a150065660aecf1ca236e2981c4e92f0
https://doi.org/10.2217/bmm-2019-0167
https://doi.org/10.2217/bmm-2019-0167
Autor:
Santosh Peddi, J. Andrew MacKay, Sarah F. Hamm-Alvarez, Changrim Lee, Stan G. Louie, Frances Yarber, Srikanth Reddy Janga, Siyu Liu, Wannita Klinngam, Nishant Tiwari, Hao Guo, Maria C. Edman
Publikováno v:
Mol Pharm
The USFDA-approved immunosuppressive drug rapamycin (Rapa), despite its potency, is limited by poor bioavailability and a narrow therapeutic index. In this study, we sought to improve bioavailability of Rapa with subcutaneous (SC) administration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9194015ce75debbd930dad03ae846173
https://doi.org/10.1021/acs.molpharmaceut.9b00263
https://doi.org/10.1021/acs.molpharmaceut.9b00263