Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Maria C Pedroso, de Lima"'
Autor:
Catarina M. Morais, Ana M. Cardoso, Ana Rita D. Araújo, Ana Reis, Pedro Domingues, Maria Rosário M. Domingues, Maria C. Pedroso de Lima, Amália S. Jurado
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13014 (2022)
Modulation of lipid metabolism is a well-established cancer hallmark, and SCD1 has been recognized as a key enzyme in promoting cancer cell growth, including in glioblastoma (GBM), the deadliest brain tumor and a paradigm of cancer resistance. The ce
Externí odkaz:
https://doaj.org/article/b8d6aeede103413499d4a6385dd409b3
Autor:
Maria Francisca Coutinho, Juliana Inês Santos, Liliana S. Mendonça, Liliana Matos, Maria João Prata, Amália S. Jurado, Maria C. Pedroso de Lima, Sandra Alves
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5732 (2020)
More than two thirds of Lysosomal Storage Diseases (LSDs) present central nervous system involvement. Nevertheless, only one of the currently approved therapies has an impact on neuropathology. Therefore, alternative approaches are under development,
Externí odkaz:
https://doaj.org/article/db790f417c684e1ab5487cc98d9a6322
Publikováno v:
Pharmaceuticals, Vol 6, Iss 10, Pp 1195-1220 (2013)
The discovery of small RNA molecules with the capacity to regulate messenger RNA (mRNA) stability and translation (and consequently protein synthesis) has revealed an additional level of post-transcriptional gene control. MicroRNAs (miRNAs), an evolu
Externí odkaz:
https://doaj.org/article/937503da075e40d1b2c28729cbdd0606
Publikováno v:
Pharmaceuticals, Vol 3, Iss 4, Pp 961-993 (2010)
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, there
Externí odkaz:
https://doaj.org/article/f18b37e6f04d46d2ab7d71cc354f541c
Autor:
Yulia Kleschenko, Girish Rachakonda, Fernando Villalta, Siddharth Pratap, Maria C. Pedroso de Lima, Ashutosh Arun, Pius N. Nde, Kayla J Rayford, Ayorinde Cooley
Publikováno v:
The FASEB Journal. 35
Autor:
Girish Rachakonda, Kayla J Rayford, Ashutosh Arun, Ayorinde Cooley, Nader Sheibani, Siddharth Pratap, Pius N. Nde, Maria C. Pedroso de Lima, Fernando Villalta
Publikováno v:
The FASEB Journal. 35
Autor:
Madalena Sousa, Marcos Barbosa, Olinda Rebelo, Hermínio Tão, Catarina M. Morais, Maria C. Pedroso de Lima, Amália S. Jurado, Ana M. Cardoso
Publikováno v:
Human molecular genetics. 30(23)
Glioblastoma (GB) is the most aggressive and common form of primary brain tumor characterized by fast proliferation, high invasion and resistance to current standard treatment. The average survival rate post-diagnosis is 14.6 months, despite the aggr
Autor:
Marina Pinheiro, Emílio Lage, Luísa Aguiar, Catarina M. Morais, M. Margarida C. A. Castro, Salette Reis, Nuno Vale, Cláudia Nunes, Paula Gomes, Maria C. Pedroso de Lima, Amália S. Jurado, Pedro P. Cunha, Ana M. Cardoso
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:2619-2634
Background Cell-penetrating peptides (CPPs) have been extensively exploited in gene therapy approaches as vectors for intracellular delivery of bioactive molecules. The ability of CPPs to be internalized into cells and their capacity to complex nucle
Autor:
Ana L. Cardoso, Carlos F. G. C. Geraldes, Otacílio Antunes Santana, Adriana Fontes, Paulo E. Cabral Filho, Maria C. Pedroso de Lima, Beate S. Santos, Mariana P. Cabrera, Giovannia A. L. Pereira
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2788-2796
Background Site-specific multimodal nanoplatforms with fluorescent-magnetic properties have great potential for biological sciences. For this reason, we developed a multimodal nanoprobe (BNPs-Tf), by covalently conjugating an optical-magnetically act
Autor:
Joaquim A.F. Vicente, Maria C. Pedroso de Lima, Sandra M.A. Santos, Susana P. Pereira, João D. Martins, Amália S. Jurado, Cláudia M. Deus, Romeu A. Videira, Maria A.S. Fernandes
Publikováno v:
Environmental pollution (Barking, Essex : 1987). 286
Several environmental pollutants, including pesticides, herbicides and persistent organic pollutants play an important role in the development of chronic diseases. However, most studies have examined environmental pollutants toxicity in target organi