Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Maria C Lebre"'
Autor:
Marieke M J Herenius, Ana S F Oliveira, Carla A Wijbrandts, Daniëlle M Gerlag, Paul P Tak, Maria C Lebre
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57802 (2013)
BACKGROUND: Chemerin is a specific chemoattractant for macrophages and dendritic cells (DC). In addition, it can rapidly stimulate macrophage adhesion to extracellular matrix proteins and adhesion molecules and is able to activate fibroblast-like syn
Externí odkaz:
https://doaj.org/article/9d5c064dba4f4af5aa8b67a41dbcd9c4
Autor:
Maria C Lebre, Clarissa E Vergunst, Ivy Y K Choi, Saïda Aarrass, Ana S F Oliveira, Tim Wyant, Richard Horuk, Kris A Reedquist, Paul P Tak
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21772 (2011)
BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model. ME
Externí odkaz:
https://doaj.org/article/9c5723f270bf4bc38ec12358c386599e
Autor:
Changpei Gan, Jing Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Els Wagenaar, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Sjoerd Klarenbeek, Rahmen Bin Ali, Colin Pritchard, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 618-631 (2023)
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout
Externí odkaz:
https://doaj.org/article/87e193186c58427c9b561d417264b90f
Autor:
Wenlong Li, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Yaogeng Wang, Dirk R. de Waart, Margarida L.F. Martins, Stéphanie van Hoppe, Maria C. Lebre, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106724- (2023)
Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized
Externí odkaz:
https://doaj.org/article/f8d2c24093e5489fb6812b02a2a65cfa
Autor:
Margarida L. F. Martins, Paniz Heydari, Wenlong Li, Alejandra Martínez-Chávez, Nikkie Venekamp, Maria C. Lebre, Luc Lucas, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The psychedelic alkaloid ibogaine is increasingly used as an oral treatment for substance use disorders, despite being unlicensed in most countries and having reported adverse events. Using wild-type and genetically modified mice, we investigated the
Externí odkaz:
https://doaj.org/article/42ec522121d9424fb99e7f0e402b71a9
Autor:
Jing Wang, M. Merve Susam, Changpei Gan, Rolf W. Sparidans, Maria C. Lebre, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1124 (2022)
EAI045 is a fourth-generation allosteric tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). It targets T790M and C797S EGFR mutants in the treatment of non-small cell lung cancer (NSCLC). EAI045 and cetuximab combined ind
Externí odkaz:
https://doaj.org/article/f35d28b40b0d4d2c8e00a50b67705a13
Autor:
Nancy H. C. Loos, Margarida L. F. Martins, Daniëlle de Jong, Maria C. Lebre, Matthijs Tibben, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Molecular Pharmaceutics. 20:2477-2489
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89f95bc34496403afc2b407e4b0bae8
https://doi.org/10.1021/acs.molpharmaceut.2c01076
https://doi.org/10.1021/acs.molpharmaceut.2c01076
Autor:
Janne W. Bolt, Arno W. van Kuijk, Marcel B. M. Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M. Gerlag, Paul P. Tak, Marleen G. van de Sande, Maria C. Lebre, Lisa G. M. van Baarsen
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 324 (2022)
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether inhibiting one cytoki
Externí odkaz:
https://doaj.org/article/af3b332d97a341f89038d54ef84ada5f
Autor:
Yaogeng Wang, Rolf W. Sparidans, Sander Potters, Rahime Şentürk, Maria C. Lebre, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1087 (2021)
Selpercatinib is a targeted, FDA-approved, oral, small-molecule inhibitor for the treatment of rearranged during transfection (RET) proto-oncogene mutation-positive cancer. Using genetically modified mouse models, we investigated the roles of the mul
Externí odkaz:
https://doaj.org/article/a3ac2265932f41afa84cd9b41d33fe43
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1761 (2021)
Repotrectinib shows high activity against ROS1/TRK/ALK fusion-positive cancers in preclinical studies. We explored the roles of multidrug efflux transporters ABCB1 and ABCG2, the OATP1A/1B uptake transporter(s), and the CYP3A complex in pharmacokinet
Externí odkaz:
https://doaj.org/article/96586ee99982471e86dd47f36c4d54e8