An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults.

Autor: Vinicius A Vieira, Emily Adland, David F G Malone, Maureen P Martin, Andreas Groll, M Azim Ansari, Maria C Garcia-Guerrero, Mari C Puertas, Maximilian Muenchhoff, Claudia Fortuny Guash, Christian Brander, Javier Martinez-Picado, Alasdair Bamford, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D Walker, Veron Ramsuran, John Frater, Pieter Jooste, Dimitra Peppa, Mary Carrington, Philip J R Goulder

Publikováno v: PLoS Pathogens, Vol 17, Iss 11, p e1010090 (2021)

Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on disease outcome. However, the HLA-B molecules influencing immune control in adults have less impact on paediatric infec

Externí odkaz: https://doaj.org/article/2772898860cf475e98f5416e7e2940e4

Robust HIV-specific CD4+ and CD8+ T-cell responses distinguish elite control in adolescents living with HIV from viremic nonprogressors

Autor: Maximilian Muenchhoff, Emily Adland, Jane Millar, John Frater, Mari C. Puertas, Mary Carrington, Maria C. Garcia-Guerrero, Denise Peluso, Philip J. R. Goulder, Beatriz Thomé, Christian Brander, Vinicius Adriano Vieira, Javier Martinez-Picado, Claudia Fortuny Guash, Julia Roider, Gareth Tudor-Williams, Alasdair Bamford

Publikováno v: AIDS (London, England)
Aids
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
AIDS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol

Background: Elite controllers are therapy-naive individuals living with HIV capable of spontaneous control of plasma viraemia for at least a year. Although viremic nonprogressors are more common in vertical HIV-infection than in adults' infection, el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c2dfb6278ca9e01547c31c1bf6d348
https://pubmed.ncbi.nlm.nih.gov/34581306

VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies

Autor: Ángel Bayón-Gil, Sara Morón-López, Javier Martinez-Picado, Julia G. Prado, Victor Urrea, Maria C. Puertas, Maria Cristina O. Salgado, Maria C. Garcia-Guerrero, Ruth Peña, Bonaventura Clotet, Esther Jiménez-Moyano

Publikováno v: mBio, Vol 12, Iss 3 (2021)
mBio
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Improved assays are critical to the successful implementation of novel HIV-1 cure strategies, given the limited ability of currently available assays to quantify true effects on the viral reservoir. As interventions based on immune clearance target i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39096fab39adeab08cf0f0ca7e22cf87
https://journals.asm.org/doi/10.1128/mBio.00560-21

An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults

Autor: Gareth Tudor-Williams, Andreas Groll, Christian Brander, M. Azim Ansari, Pieter Jooste, Mary Carrington, Maria C. Garcia-Guerrero, John Frater, Dimitra Peppa, Thumbi Ndung'u, David F. G. Malone, Alasdair Bamford, Mari C. Puertas, Bruce D. Walker, Maximilian Muenchhoff, Javier Martinez-Picado, Vinicius A Vieira, Emily Adland, Philip J. R. Goulder, Claudia Fortuny Guash, Veron Ramsuran, Maureen P. Martin

Publikováno v: PLoS Pathogens
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
PLoS Pathogens, Vol 17, Iss 11, p e1010090 (2021)

Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on disease outcome. However, the HLA-B molecules influencing immune control in adults have less impact on paediatric infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af4e1a1f76ccea5ef34e2ace0730bf5
https://doi.org/10.1371/journal.ppat.1010090

Erratum for Puertas et al., 'VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies'

Autor: Maria C. Puertas, Ángel Bayón-Gil, Maria C. Garcia-Guerrero, Maria Salgado, Víctor Urrea, Sara Morón-López, Ruth Peña, Esther Jiménez-Moyano, Bonaventura Clotet, Julia G. Prado, Javier Martinez-Picado

Publikováno v: mBio, Vol 12, Iss 5 (2021)

Externí odkaz: https://doaj.org/article/41cd6c455a784502b8ccafa42c2c3569