Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

Autor: Fani Roumelioti, Christos Tzaferis, Dimitris Konstantopoulos, Dimitra Papadopoulou, Alejandro Prados, Maria Sakkou, Anastasios Liakos, Panagiotis Chouvardas, Theodore Meletakos, Yiannis Pandis, Niki Karagianni, Maria C Denis, Maria Fousteri, Maria Armaka, George Kollias

Publikováno v: eLife, Vol 13 (2024)

miRNAs constitute fine-tuners of gene expression and are implicated in a variety of diseases spanning from inflammation to cancer. miRNA expression is deregulated in rheumatoid arthritis (RA); however, their specific role in key arthritogenic cells s

Externí odkaz: https://doaj.org/article/e5d50d4d00c3408c8809b26c70ef81cd

TNF overexpression and dexamethasone treatment impair chondrogenesis and bone growth in an additive manner

Autor: Yunhan Zhao, Bettina Celvin, Maria C. Denis, Niki Karagianni, Cecilia Aulin, Farasat Zaman, Lars Sävendahl

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Children with chronic inflammation are often treated with glucocorticoids (GCs) and many of them experience growth retardation. It is poorly understood how GCs interact with inflammatory cytokines causing growth failure as earlier experiment

Externí odkaz: https://doaj.org/article/2402ec5452e543b08d1b549842f78486

Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis

Autor: Dimitra Papadopoulou, Fani Roumelioti, Christos Tzaferis, Panagiotis Chouvardas, Anna-Kathrine Pedersen, Filippos Charalampous, Eleni Christodoulou-Vafeiadou, Lydia Ntari, Niki Karagianni, Maria C. Denis, Jesper V. Olsen, Alexios N. Matralis, George Kollias

Publikováno v: Papadopoulou, D, Roumelioti, F, Tzaferis, C, Chouvardas, P, Pedersen, A-K, Charalampous, F, Christodoulou-Vafeiadou, E, Ntari, L, Karagianni, N, Denis, M C, Olsen, J V, Matralis, A N & Kollias, G 2023, ' Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis ', JCI insight, vol. 8, no. 9, e165024 . https://doi.org/10.1172/jci.insight.165024

Synovial fibroblasts (SFs) are key pathogenic drivers in rheumatoid arthritis (RA). Their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models, and TNF blockade proved efficacious for a high percentage o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4e599266cb2031c1ac782736bbc371
https://doi.org/10.1172/jci.insight.165024

Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment

Autor: Panagiotis Chouvardas, Lydia Ntari, Florian Meier, Niki Karagianni, Christoforos Nikolaou, Maria C Denis, Ksanthi Kranidioti, Dimitra Papadopoulou, Eleni Christodoulou-Vafeiadou, George Kollias, Christina Geka

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Journal of Translational Medicine
Ntari, Lydia; Nikolaou, Christoforos; Kranidioti, Ksanthi; Papadopoulou, Dimitra; Christodoulou-Vafeiadou, Eleni; Chouvardas, Panagiotis; Meier, Florian; Geka, Christina; Denis, Maria C; Karagianni, Niki; Kollias, George (2021). Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment. Journal of translational medicine, 19(1), p. 165. BioMed Central 10.1186/s12967-021-02764-y

Background New medications for Rheumatoid Arthritis (RA) have emerged in the last decades, including Disease Modifying Antirheumatic Drugs (DMARDs) and biologics. However, there is no known cure, since a significant proportion of patients remain or b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1b1cfee6f7d565dac510e282e3568a
https://publica.fraunhofer.de/handle/publica/269058

Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis

Autor: George Loudos, Ksanthi Kranidioti, Eleni Christodoulou-Vafeiadou, Lydia Ntari, Maria C Denis, Florian Meier, Niki Karagianni, Eleni Argyropoulou, Maritina Rouchota, Marietta Armaka, George Kollias, Constantinos Pantos, Iordanis Mourouzis, Christina Geka

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-14 (2020)
Arthritis Research & Therapy

Background The transmembrane-TNF transgenic mouse, TgA86, has been shown to develop spontaneously peripheral arthritis with signs of axial involvement. To assess similarity to human spondyloarthritis, we performed detailed characterization of the axi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087ce2842284ef0c885de02c830d3e49
https://doi.org/10.1101/2020.05.14.095588