Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Maria C, Ochoa"'
Autor:
Ignacio Melero, Maria C Ochoa, Carmen Molina, Sandra Sanchez‐Gregorio, Saray Garasa, Carlos Luri‐Rey, Sandra Hervas‐Stubbs, Noelia Casares, Edurne Elizalde, Gabriel Gomis, Assunta Cirella, Pedro Berraondo, Alvaro Teijeira, Maite Alvarez
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-16 (2023)
Abstract NK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice. We found that in
Externí odkaz:
https://doaj.org/article/dad7d8e3e32044ab82bb7ccfc15b4a39
Autor:
Assunta Cirella, Elixabet Bolaños, Carlos Luri-Rey, Claudia Augusta Di Trani, Irene Olivera, Gabriel Gomis, Javier Glez-Vaz, Beatrice Pinci, Saray Garasa, Sandra Sánchez-Gregorio, Arantza Azpilikueta, Iñaki Eguren-Santamaria, Karmele Valencia, Belén Palencia, Maite Alvarez, Maria C. Ochoa, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 668-682 (2023)
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have constructed c
Externí odkaz:
https://doaj.org/article/0cbeb48e82c4432eb1d5f41226df6231
Autor:
Maite Alvarez, Carmen Molina, Saray Garasa, Maria C. Ochoa, Maria E Rodriguez-Ruiz, Gabriel Gomis, Assunta Cirella, Irene Olivera, Javier Glez-Vaz, Jose Gonzalez-Gomariz, carlos luri-Rey, arantza azpilikueta, Elixabet Bolaños, Alvaro Teijeira, Pedro Berraondo, Marisol Quintero, Ignacio Melero
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTBO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-refr
Externí odkaz:
https://doaj.org/article/44e860c9bad74e59994cd04f69e8b8a5
Autor:
Arantza Azpilikueta, Ignacio Melero, Sonia Guedan, Alvaro Teijeira, Lieping Chen, Maria C Ochoa, Maite Alvarez, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Assunta Cirella, Javier Glez-Vaz, Irene Olivera, Iñaki Eguren-Santamaria, Carlos Luri-Rey, Xinxin Nie
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD
Externí odkaz:
https://doaj.org/article/73397a239a8744e29c59d4accc19c284
Autor:
Pedro Berraondo, Arantza Azpilikueta, Elixabet Bolaños, Ignacio Melero, Alvaro Teijeira, Saray Garasa, Iñaki Etxeberrria, Luna Minute, Alfonso R Sanchez-Paulete, Maria C Ochoa, Maite Alvarez, Itziar Otano, Noelia Casares, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background The immune response to cancer is often conceptualized with the cancer immunity cycle. An essential step in this interpretation is that antigens released by dying tumors are presented by dendritic cells to naive or memory T cells in the tum
Externí odkaz:
https://doaj.org/article/d58ea55e54684bcd916788f79617cf27
Autor:
Maria C. Ochoa, Elisabeth Perez-Ruiz, Luna Minute, Carmen Oñate, Guiomar Perez, Inmaculada Rodriguez, Aintzane Zabaleta, Diego Alignani, Myriam Fernandez-Sendin, Ascension Lopez, Aura Muntasell, Miguel F. Sanmamed, Bruno Paiva, Miguel Lopez-Botet, Pedro Berraondo, Ignacio Melero
Publikováno v:
OncoImmunology, Vol 8, Iss 7 (2019)
Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD13
Externí odkaz:
https://doaj.org/article/469445f7b4c148028345cf1278b80df7
Autor:
Aura Muntasell, Miguel López-Botet, Ignacio Melero, Joan Albanell, Pedro Berraondo, Ana Rovira, Laura Comerma, Silvia Menéndez, Maria C. Ochoa, Manel Juan, Francesc Balaguer, Michelle Ataya, Roberto Lozano-Rodríguez, Anna Rea, Marcel Costa-Garcia, Sara Santana-Hernández, Mariona Cabo
Enhancing natural killer (NK) cell–based cancer immunotherapy by overcoming immunosuppression is an area of intensive research. Here, we have demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55eece933a417d140ac1db0cf999894f
https://doi.org/10.1158/2326-6066.c.6550737
https://doi.org/10.1158/2326-6066.c.6550737
Autor:
Aura Muntasell, Miguel López-Botet, Ignacio Melero, Joan Albanell, Pedro Berraondo, Ana Rovira, Laura Comerma, Silvia Menéndez, Maria C. Ochoa, Manel Juan, Francesc Balaguer, Michelle Ataya, Roberto Lozano-Rodríguez, Anna Rea, Marcel Costa-Garcia, Sara Santana-Hernández, Mariona Cabo
Supplementary Tables 1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449e4c5b3d758f00fca862c9c9a65b7f
https://doi.org/10.1158/2326-6066.22544733
https://doi.org/10.1158/2326-6066.22544733
Autor:
Aura Muntasell, Miguel López-Botet, Ignacio Melero, Joan Albanell, Pedro Berraondo, Ana Rovira, Laura Comerma, Silvia Menéndez, Maria C. Ochoa, Manel Juan, Francesc Balaguer, Michelle Ataya, Roberto Lozano-Rodríguez, Anna Rea, Marcel Costa-Garcia, Sara Santana-Hernández, Mariona Cabo
Figures S1, S2, S3, S4, S5, S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a548f5f74c4c2013976fb00126d05a
https://doi.org/10.1158/2326-6066.22544736
https://doi.org/10.1158/2326-6066.22544736
Autor:
Luis Alvarez-Vallina, Laura Sanz, Luis Paz-Ares, José L. Rodriguez-Peralto, Ignacio Melero, Ines G. Muñoz, Miguel A. Morcillo, Francisco J. Blanco, Angel Ramírez-Fernández, Manuela Zonca, Carmen Domínguez-Alonso, Oana Hangiu, Daniel Nehme-Álvarez, Nekane Merino, Marta Oteo, Belén Blanco, Maria C. Ochoa, Ana B. Enguita, Eva M. Garrido-Martin, Irene Ferrer, Eduardo Romero, Antonio Tapia-Galisteo, Ainhoa Erce-Llamazares, Seandean L. Harwood, Marta Compte
Structural and functional characterization of 4-1BBN/CEGFR after conjugation with p-SCN-Bn-deferoxamine (Df).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3945f0c7eb0bace17584c12704fcea
https://doi.org/10.1158/1078-0432.22479489.v1
https://doi.org/10.1158/1078-0432.22479489.v1