Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Maria C, Courreges"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Clostridioides difficile infection (CDI) with high morbidity and high mortality is an urgent threat to public health, and C. difficile pathogenesis studies are eagerly required for CDI therapy. The major surface layer protein, SlpA, was supp
Externí odkaz:
https://doaj.org/article/39c74bf700a34c81ab2ae6bbef9205f6
Autor:
Fabian Benencia, Ramiro Malgor, Frank L. Schwartz, Maria C. Courreges, Jean R. Thuma, Calvin B. L. James, Kelly D. McCall, Martin J. Schmerr
Publikováno v:
Molecules, Vol 18, Iss 4, Pp 3841-3858 (2013)
Accumulating evidence supports a role for viruses in the pathogenesis of type 1 diabetes mellitus (T1DM). Activation of dsRNA-sensing pathways by viral dsRNA induces the production of inflammatory cytokines and chemokines that trigger beta cell apopt
Externí odkaz:
https://doaj.org/article/4bdf4211b1c940919f580158bf698619
Publikováno v:
Molecules, Vol 17, Iss 10, Pp 12365-12377 (2012)
Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling. In the present study, we investigated the molecular basis for C10 i
Externí odkaz:
https://doaj.org/article/220fb7a660d54ccba67f4a67989d2e88
Autor:
Maria C. Courreges, Stephen C. Bergmeier, Douglas J. Goetz, Mahboubeh S. Noori, Kelly D. McCall
Publikováno v:
European Journal of Pharmacology
Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. a cytokine storm. For sepsis involving gram-negative b
Autor:
Kelly D. McCall, Mahboubeh S. Noori, Crina M. Orac, Mark C. McMills, Chaz M. Cuckler, Douglas J. Goetz, Davoud Ghazanfari, Maria C. Courreges, Stephen C. Bergmeier, Pooja Bhatt, Sudhir P. Deosarkar, Frank L. Schwartz
Publikováno v:
Am J Physiol Cell Physiol
Glycogen synthase kinase-3 (GSK-3) is a multitasking protein kinase that regulates numerous critical cellular functions. Not surprisingly, elevated GSK-3 activity has been implicated in a host of diseases including pathological inflammation, diabetes
Autor:
Douglas J. Goetz, Mahboubeh S. Noori, Kelly D. McCall, Maria C. Courreges, Stephen C. Bergmeier
Publikováno v:
The FASEB Journal. 32
Autor:
Maria C. Courreges, Fabian Benencia, John McGinty, Michelle Pate, Kristen Mansfield, Venktesh S. Shirure, Maria Muccioli, Leslee Sprague, Jacob Osterbur, Yihan Li, Yandi Li
Publikováno v:
Immunobiology. 218:64-75
Dendritic cells (DCs) are antigen presenting cells capable of inducing specific immune responses against microbial infections, transplant antigens, or tumors. DCs have been shown to possess a high plasticity showing different phenotypes in response t
Publikováno v:
Molecules, Vol 17, Iss 10, Pp 12365-12377 (2012)
Molecules; Volume 17; Issue 10; Pages: 12365-12377
Molecules
Molecules; Volume 17; Issue 10; Pages: 12365-12377
Molecules
Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling. In the present study, we investigated the molecular basis for C10 i
Autor:
Alisha Mohammed-Hadley, George Coukos, Maria C. Courreges, Fabian Benencia, Jose R. Conejo-Garcia
Publikováno v:
Cancer Biology & Therapy. 5:867-874
We tested whether tumor cells were killed by replication-incompetent recombinant herpes simplex virus (HSV) d120 lacking immediate early gene ICP4 and whether HSVd120-killed tumor cells could be used directly for tumor vaccination. Vaccine efficacy w
Autor:
Maria C. Courreges, Richard G. Carroll, Ronald J. Buckanovich, Nigel W. Fraser, Fabian Benencia, Alisha Mohamed-Hadley, Jose R. Conejo-Garcia, George Coukos, Lin Zhang
Publikováno v:
Molecular Therapy. 12:789-802
Cooperation between oncolytic herpes simplex virus (HSV) and host effector immune mechanisms has been previously described. In the present study, we investigated the mechanism underlying such cooperation in a murine syngeneic model of ovarian carcino