HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Autor: Milana A. Bergamino, Elena López-Knowles, Gabriele Morani, Holly Tovey, Lucy Kilburn, Eugene F. Schuster, Anastasia Alataki, Margaret Hills, Hui Xiao, Chris Holcombe, Anthony Skene, John F. Robertson, Ian E. Smith, Judith M. Bliss, Mitch Dowsett, Maggie C.U. Cheang, Abigail Evans, Adrian Ball, Akhil Johri, Ali Nejim, Alison Jones, Allan Corder, Amanda Thorne, Ambika Anand, Amitabha Chakrabarti, Anne Robinson, Anupam Modi, Ashraf Patel, Ashutosh Kothari, Brendan McFall, Caroline Mortimer, Caroline Lee, Charlie Chan, Charlotte Abson, Christopher Holcombe, Christopher Hinton, Ciaran Hollywood, Claire Murphy, Clare Crowley, Claudia Harding-Mackean, Clive Griffith, Conrad Lewanski, Daniel Rea, David Hwang, Derek Crawford, Dinesh Thekkinkattil, Douglas Ferguson, Douglas Adamson, Duncan Wheatley, Duraisamy Ravichandran, Ed Babu, Elaine Hyett, Fawzia Ashkanani, Fiona Hoar, Frances Kenny, Gary Dyke, Geoffrey Sparrow, null Gilbert, Giles Cunnick, Hafiz Algurafi, Helen Sweetland, Highes-Davies Prof, Hisham Hamed, Ian Smith, Ian Laidlaw, Ilyas Khattak, Jacqueline Newby, Jacqueline Rees-Lee, Jalal Kokan, Jane Barrett, Jay Dolatrai Naik, Jayant Vaidya, Jennifer Forrest, Jitendra Parmar, Jocelyn Adams, John Fox, Jonathan Roberts, Jonathan Dawson, Julie Doughty, Jull Donnelly, Kathleen Dunn, Kian Chin, Kieran Horgan, Kislaya Thakur, Ludger Barthelmes, Lynda Wyld, Madhumita Bhattacharyya, Maher Hadaki, Makam Kishore, Marcus Ornstein, Maria Bramley, Maria Bews-Hair, Marina Parton, Mark Sibbering, Mark Kissin, Mark Churn, Martin Hogg, Mary Quigley, Matthew Hatton, Matthew Winter, Matthew Adelekan, Michael Shere, Michael Carr, Michael Williams, Mohammed Absar, Muhammad Sharif, Muireann Kelleher, Nawaz Walji, Nicholas Williams, Nicholas Gallegos, Nigel Bundred, Olivia Hatcher, Perric Crellin, Peter Crane, Peter Donnelly, Peter Kneeshaw, Philip Walker, Prakash Sinha, Pudhupalayam Bhaskar, Racheal Soulsby, Radha Todd, Raghavan Vidya, Rakesh Mehra, Ramachandran Prasad, Ramsay Cutress, Ravi Sharma, Rebecca Roylance, Rebecca Goranova, Reem Ramzi Salman, Riccardo Bonom, Richard Johnson, Richard Sutton, Rick Linforth, Rob Coleman, Robert Grieve, Robert Leonard, Robert Reichert, Robert Kennedy, Roshan Agarwal, Rozenn Allerton, Russell Burcombe, Ruth Davis, Sankaran Narayanan, Sankaran Chandrasekharan, Sarah Vesty, Seema Seetharam, Serena Ledwidge, Shabana Iqbal, Shamaela Wahee, Shobha Silva, Simon Pain, Simon Holt, Simon Thomson, Simon Smith, Simon Ellenbogen, Siobhan Laws, Stephen Chan, Stephen Johnston, Steve Holt, Steven Thrush, Stuart McIntosh, Sumohan Chatterjee, Susan Cleator, Tamoor Usman, Tayo Johnson, Tibor Kovacs, Tracey Irvine, Urmila Barthkur, Vanessa Pope, Victoria Alexandra Brown, Vummiti Muralikrishna, Walid Samra, William Maxwell, Zoe Winters

Publikováno v: EBioMedicine. 83

Background: oestrogen receptor positive/ human epidermal growth factor receptor positive (ER+/HER2+) breast cancers (BCs) are less responsive to endocrine therapy than ER+/HER2- tumours. Mechanisms underpinning the differential behaviour of ER+HER2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c36f0affe9cade26299ca49ee96f2
https://pubmed.ncbi.nlm.nih.gov/35985932

Abstract P1-11-05: Withdrawn

Autor: P. Foden, Andrew Evans, Arnie Purushotham, Julie Morris, Anthony Skene, Maria Bramley, Chris Todd, Katie Riches, Vaughan Keeley, D. Watterson, Nigel J Bundred

Publikováno v: Cancer Research. 79:P1-11

This abstract was withdrawn by the authors. Citation Format: Bundred NJ, Foden P, Riches K, Morris J, Evans A, Todd C, Bramley M, Skene A, Watterson D, Purushotham A, Keeley V. Withdrawn [abstract]. In: Proceedings of the 2018 San Antonio Breast Canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d3edd3477f16129d4f791803656bd79
https://doi.org/10.1158/1538-7445.sabcs18-p1-11-05

Increases in arm volume predict lymphoedema and quality of life deficits after axillary surgery: a prospective cohort study

Autor: Anthony Skene, Phil Foden, Julie Morris, Vaughan Keeley, Donna Watterson, Katie Riches, Nigel J Bundred, Chris Todd, Tracey Hodgkiss, Abigail Evans, Arnie Purushotham, Maria Bramley

Publikováno v: Bundred, N, Foden, P, Todd, C, Morris, J, Watterson, D, Purushotham, A, Bramley, M, Riches, K, Hodgkiss, T, Evans, A, Skene, A & Keeley, V 2020, ' Increases in arm volume predict lymphoedema and quality of life deficits after axillary surgery: a prospective cohort study ', British Journal of Cancer, vol. 123, no. 1, pp. 17-25 . https://doi.org/10.1038/s41416-020-0844-4

Background Lymphoedema develops after axillary clearance (ANC) in 25% of patients. This prospective, multi-centre study compared multi-frequency bioimpedance spectroscopy (BIS) with arm volume measurement to: (1) determine which test has better diagn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f67dd74549b80c6f73b49d53d844cd
https://doi.org/10.1038/s41416-020-0844-4

Comment on: ‘Increases in arm volume predict lymphoedema and quality of life deficits after axillary surgery: a prospective cohort study.’

Autor: Nigel, Bundred, Phil, Foden, Chris, Todd, Julie, Morris, Donna, Watterson, Arnie, Purushotham, Maria, Bramley, Katie, Riches, Tracey, Hodgkiss, Abigail, Evans, Anthony, Skene, Vaughan, Keeley

Publikováno v: British Journal of Cancer

Lymphoedema develops after axillary clearance (ANC) in 25% of patients. This prospective, multi-centre study compared multi-frequency bioimpedance spectroscopy (BIS) with arm volume measurement to: (1) determine which test has better diagnostic accur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd7ebe6b23e82e23c210e5e8dbec754
http://europepmc.org/articles/PMC8076231

Individualising breast cancer treatment to improve survival and minimise complications in older women: a research programme including the PLACE RCT

Autor: Katie Riches, Chris Todd, Adrian Bagust, Julie Morris, Philip Foden, Arnie Purushotham, Maria Bramley, Vaughan Keeley, Nigel J Bundred

Publikováno v: Programme Grants for Applied Research, Vol 7, Iss 5 (2019)
Bundred, N, Todd, C, Morris, J, Keeley, V, Purushotham, A, Bagust, A, Foden, P, Bramley, M & Riches, K 2019, ' Individualising breast cancer treatment to improve survival and minimise complications in older women: a research programme including the PLACE RCT ', Programme Grants Appl Res, vol. 7, no. 5, pp. 1-260 . https://doi.org/10.3310/pgfar07050

BackgroundOver 44,000 women are diagnosed with breast cancer annually in the UK. The research comprised three workstreams (WSs) focused on older women.Maximising survivalWS1 – to identify the role of older women’s and surgeons’ preferences in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3dc98e554ccca2f91d92f6f47fffc9
https://doaj.org/article/40e5adcda45841c8b063fd75f15d2e96