Clinical interpretation of cell-based non-invasive prenatal testing for monogenic disorders including repeat expansion disorders: potentials and pitfalls

Autor: Line Dahl Jeppesen, Lotte Hatt, Ripudaman Singh, Palle Schelde, Katarina Ravn, Christian Liebst Toft, Maria Bach Laursen, Jakob Hedegaard, Inga Baasch Christensen, Bolette Hestbek Nicolaisen, Lotte Andreasen, Lars Henning Pedersen, Ida Vogel, Dorte Launholt Lildballe

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Introduction: Circulating fetal cells isolated from maternal blood can be used for prenatal testing, representing a safe alternative to invasive testing. The present study investigated the potential of cell-based noninvasive prenatal testing (NIPT) f

Externí odkaz: https://doaj.org/article/1de434c9e29148f39b2d71fd2aed3f72

Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells.

Autor: Benyamin Ranjbar, Louise Bechmann Krogh, Maria Bach Laursen, Maria Nascimento Primo, Sara Correia Marques, Karen Dybkær, Jacob Giehm Mikkelsen

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153069 (2016)

Diffuse large B-cell lymphoma (DLBCL) is characterized by great genetic and clinical heterogeneity which complicates prognostic prediction and influences treatment efficacy. The most common regimen, R-CHOP, consists of a combination of anthracycline-

Externí odkaz: https://doaj.org/article/b6092941c80540d19e24d720a0c92118

Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

Autor: Anders Husted Madsen, Maria Bach Laursen, Claus L. Andersen, Michael Knudsen, Kåre Gotschalck Sunesen, Amanda Frydendahl Boll Johansen, Mads Rasmussen, Lene Hjerrild Iversen, Christine Gaasdal Kassentoft

Publikováno v: BMC Cancer
Johansen, A F B, Kassentoft, C G, Knudsen, M, Laursen, M B, Madsen, A H, Iversen, L H, Sunesen, K G, Rasmussen, M H & Andersen, C L 2019, ' Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients ', BMC Cancer, vol. 19, no. 1, 971 . https://doi.org/10.1186/s12885-019-6227-7
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)

Background Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34b908ddfa51e4f3c01642a71563552
http://europepmc.org/articles/PMC6802299

Molecular classification of tissue from a transformed non-Hogkin's lymphoma case with unexpected long-time remission

Autor: Steffen Falgreen, Maria Bach Laursen, Rasmus Froberg Brøndum, Linn Reinholdt, Alexander Schmitz, Anna Amanda Schönherz, Martin Bøgsted, Karen Dybkær, Hanne Due, Marianne Tang Severinsen, Mette Nyegaard, Hans Erik Johnsen, Lasse Hjort Jakobsen, Tarec Christoffer El-Galaly, Julie Støve Bødker

Publikováno v: Bødker, J S, Severinsen, M T, El-Galaly, T C, Brøndum, R F, Laursen, M B, Larsen, S F, Nyegaard, M, Schmitz, A, Jakobsen, L H, Schönherz, A A, Due, H, Reinholdt, L, Bøgsted, M, Dybkær, K & Johnsen, H E 2017, ' Molecular classification of tissue from a transformed non-Hogkin's lymphoma case with unexpected long-time remission ', Experimental Hematology & Oncology, vol. 6, 3 . https://doi.org/10.1186/s40164-016-0063-0
Experimental Hematology & Oncology

Background The concept of precision medicine in cancer includes individual molecular studies to predict clinical outcomes. In the present N = 1 case we retrospectively have analysed lymphoma tissue by exome sequencing and global gene expression in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02807553a40a8bb1558878e8bda14af5
https://vbn.aau.dk/da/publications/c11d8826-a5a8-4d0c-abc4-a0965e879bd3

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Autor: Chuanzheng Zhou, Dalibor Odadzic, Malgorzata Wenska, Torben Højland, Jens Haas, Jesper Wengel, Claus Bus, Maria Bach Laursen, Joachim W. Engels, Cordula Andree, Thomas F. Meyer, Puneet Srivastava, Simone Hess, Marino Zerial, Piet Herdewijn, Eugenio Fava, Jyoti Chattopadhyaya, Niels Langkjær, Elke Müller, Anne Færch Nielsen, Thomas B. Hansen, Mikhail Abramov, Romualdas Smicius, Dmytro Honcharenko, Georgii V. Bobkov, B. Ravindra Babu, Jesper B. Bramsen, Sergey N. Mikhailov, Jørgen Kjems, Arthur Van Aerschot, Jharna Barman

Publikováno v: Nucleic Acids Research
Bramsen, J B, Laursen, M B, Nielsen, A F, Hansen, T B, Bus, C, Langkjær, N, Babu, B R, Hojland, T, Abramov, M, Van Aerschot, A, Odadzic, D, Smicius, R, Haas, J, Andree, C, Barman, J, Wenska, M, Srivastava, P, Zhou, C, Honcharenko, D, Hess, S, Hess, S, Bobkov, G V, Mikhailov, S N, Fava, E, Meyer, T F, Chattopadhyaya, J, Zerial, M, Engels, J W, Herdewijn, P, Wengel, J & Kjems, J 2009, ' A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity ', Nucleic Acids Research, vol. 37, no. 9, pp. 2867-2881 . https://doi.org/10.1093/nar/gkp106
Bramsen, J B, Laursen, M B, Nielsen, A F, Hansen, T B, Bus, C, Langkjær, N, Babu, B R, Højland, T, Abramov, M, Van Aerschot, A, Odadzic, D, Smicius, R, Haas, J, Andree, C, Barman, J, Wenska, M, Srivastava, P, Zhou, C, Honcharenko, D, Hess, S, Müller, E, Bobkov, G V, Mikhailov, S N, Fava, E, Meyer, T F, Chattopadhyaya, J, Zerial, M, Engels, J W, Herdewijn, P, Wengel, J & Kjems, J 2009, ' A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity ', Nucleic Acids Research, vol. 37, no. 9, pp. 2867-81 . https://doi.org/10.1093/nar/gkp106

The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is expectably required for successful application in vivo. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d12ff51f23c57bc31c94686cee7eb8
https://doi.org/10.1093/nar/gkp106