Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria B. Goncalves"'
Autor:
Maria B. Goncalves, Yue Wu, Earl Clarke, John Grist, Julien Moehlin, Marco Antonio Mendoza-Parra, Carl Hobbs, Barret Kalindjian, Henry Fok, Adrian P. Mander, Hana Hassanin, Daryl Bendel, Jörg Täubel, Tim Mant, Thomas Carlstedt, Julian Jack, Jonathan P. T. Corcoran
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Retinoic acid receptor β2 (RARβ2) is an emerging therapeutic target for spinal cord injuries (SCIs) with a unique multimodal regenerative effect. We have developed a first-in-class RARβ agonist drug, C286, that modulates neuron-glial pathways to i
Externí odkaz:
https://doaj.org/article/fc6f78e235584c4a814b98223f1ff1d8
Autor:
Maria B. Goncalves, Julien Moehlin, Earl Clarke, John Grist, Carl Hobbs, Antony M. Carr, Julian Jack, Marco Antonio Mendoza-Parra, Jonathan P.T. Corcoran
Publikováno v:
iScience, Vol 20, Iss , Pp 554-566 (2019)
Summary: Neuropathic pain (NP) is associated with profound gene expression alterations within the nociceptive system. DNA mechanisms, such as epigenetic remodeling and repair pathways have been implicated in NP. Here we have used a rat model of perip
Externí odkaz:
https://doaj.org/article/8551eb581aa8412dbb09b8e31da54c5a
Autor:
Maria B. Goncalves, Yue Wu, Diogo Trigo, Earl Clarke, Tony Malmqvist, John Grist, Carl Hobbs, Thomas P. Carlstedt, Jonathan P.T. Corcoran
Publikováno v:
Neurobiology of Disease, Vol 111, Iss , Pp 70-79 (2018)
Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads to regeneration in the adult nervous system and numerous studies have shown that the specific activation of the retinoic acid receptor β (RARβ) is required
Externí odkaz:
https://doaj.org/article/8c968baf906f42549a15f27578a639b1
Autor:
Antony M. Carr, Carl Hobbs, Jonathan Corcoran, Julian Jack, Maria B. Goncalves, Julien Moehlin, John Grist, Earl Clarke, Marco Antonio Mendoza-Parra
Publikováno v:
Goncalves, M B, Moehlin, J, Clarke, E, Grist, J, Hobbs, C, Carr, A M, Jack, J, Mendoza-Parra, M A & Corcoran, J P T 2019, ' RARβ agonist drug (C286) demonstrates efficacy in a pre-clinical neuropathic pain model restoring multiple pathways via DNA repair mechanisms ', iScience, vol. 20, pp. 554-566 . https://doi.org/10.1016/j.isci.2019.09.020
iScience
iScience, Elsevier, 2019, 20, pp.554-566. ⟨10.1016/j.isci.2019.09.020⟩
iScience, 2019, 20, pp.554-566. ⟨10.1016/j.isci.2019.09.020⟩
iScience, Vol 20, Iss, Pp 554-566 (2019)
iScience
iScience, Elsevier, 2019, 20, pp.554-566. ⟨10.1016/j.isci.2019.09.020⟩
iScience, 2019, 20, pp.554-566. ⟨10.1016/j.isci.2019.09.020⟩
iScience, Vol 20, Iss, Pp 554-566 (2019)
Summary Neuropathic pain (NP) is associated with profound gene expression alterations within the nociceptive system. DNA mechanisms, such as epigenetic remodeling and repair pathways have been implicated in NP. Here we have used a rat model of periph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ec446be6531d3c4f27cfa5676ad5e9
https://kclpure.kcl.ac.uk/ws/files/124208802/RAR_agonist_drug_C286_demonstrates_GONCALVES_Accepted12September2019_Published25October2019_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/124208802/RAR_agonist_drug_C286_demonstrates_GONCALVES_Accepted12September2019_Published25October2019_GOLD_VoR_CC_BY_.pdf
Publikováno v:
The FASEB Journal
Neuronal regeneration is a highly energy-demanding process that greatly relies on axonal mitochondrial transport to meet the enhanced metabolic requirements. Mature neurons typically fail to regenerate after injury, partly because of mitochondrial mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09f7a7f9f4d32484594f08cceca73c9c
https://pubmed.ncbi.nlm.nih.gov/30857414
https://pubmed.ncbi.nlm.nih.gov/30857414
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
Retinoic acid receptors (RARs) α, β, and γ are members of the nuclear receptor superfamily. Compounds which bind to and activate the RARs are termed retinoids which regulate a wide variety of biological processes such as ve
Retinoic acid receptors (RARs) α, β, and γ are members of the nuclear receptor superfamily. Compounds which bind to and activate the RARs are termed retinoids which regulate a wide variety of biological processes such as ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd24e85916fd8df1e0b05c476953b63
https://doi.org/10.1016/j.bmc.2020.115664
https://doi.org/10.1016/j.bmc.2020.115664
Autor:
Carl Hobbs, S. Barret Kalindjian, John Grist, Thomas Carlstedt, Jonathan Corcoran, Maria B. Goncalves, Peter Mumford, Christopher I. Jarvis, Earl Clarke, Mark Trevor Mills, Jane Theresa Brown, Alan D. Borthwick, Julian Jack, Thomas Pitcher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Oxadiazole replacement of an amide linkage in an RARα agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARβ agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid (10) with good ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cac033e762913965dd8ab36d045c10c
https://doi.org/10.1016/j.bmcl.2019.05.058
https://doi.org/10.1016/j.bmcl.2019.05.058
Autor:
Earl, Clarke, Christopher I, Jarvis, Maria B, Goncalves, S Barret, Kalindjian, David R, Adams, Jane T, Brown, Jason J, Shiers, David M A, Taddei, Elodie, Ravier, Stephanie, Barlow, Iain, Miller, Vanessa, Smith, Alan D, Borthwick, Jonathan P T, Corcoran
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a651db96aeac6253440f0f177d2dd404
https://pubmed.ncbi.nlm.nih.gov/29288071
https://pubmed.ncbi.nlm.nih.gov/29288071
Autor:
Malcolm Maden, Maria B. Goncalves, M. Dogruel, S. B. Kalindjian, Earl Clarke, Sarah A. Thomas, Christopher I. Jarvis, Jonathan Corcoran
Publikováno v:
European Journal of Neuroscience. 32:1246-1255
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain, neuronal cell loss and cognitive decline. We show here that retinoic acid receptor (RAR)α signalling in vitro can prevent both intracellular and extracellular Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843ea2cbc8006b3d675401799ef83b52
https://doi.org/10.1111/j.1460-9568.2010.07426.x
https://doi.org/10.1111/j.1460-9568.2010.07426.x
Autor:
Gareth Williams, Emma Williams, Ping K. Yip, Rafael J. Yáñez-Muñoz, Maria B. Goncalves, Patrick Doherty
Publikováno v:
British Journal of Pharmacology. 159:1118-1125
Background and purpose: In adults, neurogenesis persists in the hippocampus and the subventricular zone (SVZ), and this is important for learning and memory. Inhibitors of COX-2 suppress ischaemia-induced neurogenesis in the hippocampus. Here, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1ce7c745fa83749dbc0e8479b92ef2a
https://doi.org/10.1111/j.1476-5381.2009.00618.x
https://doi.org/10.1111/j.1476-5381.2009.00618.x