Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Maria B Grant"'
Autor:
Halesha D Basavarajappa, Rania S Sulaiman, Xiaoping Qi, Trupti Shetty, Sardar Sheik Pran Babu, Kamakshi L Sishtla, Bit Lee, Judith Quigley, Sameerah Alkhairy, Christian M Briggs, Kamna Gupta, Buyun Tang, Mehdi Shadmand, Maria B Grant, Michael E Boulton, Seung‐Yong Seo, Timothy W Corson
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 6, Pp 786-801 (2017)
Abstract Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and re
Externí odkaz:
https://doaj.org/article/3e824506a6224c1eb5ab5fcfef835898
Autor:
Ana Leda F Longhini, Tatiana E Salazar, Cristiano Vieira, Thao Trinh, Yaqian Duan, Louise M Pay, Sergio Li Calzi, Megan Losh, Nancy A Johnston, Huisheng Xie, Minsu Kim, Robert J Hunt, Mervin C Yoder, Domenico Santoro, Taralyn M McCarrel, Maria B Grant
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212642 (2019)
Previously, we showed that mesenchymal stem cells (MSC) can be mobilized into peripheral blood using electroacupuncture (EA) at acupoints, LI-4, LI-11, GV-14, and GV-20. The purpose of this study was to determine whether EA-mobilized MSC could be har
Externí odkaz:
https://doaj.org/article/03c911fffca74ccd994997d97617e4f1
Publikováno v:
Cells, Vol 9, Iss 4, p 905 (2020)
Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent retina and to determine if this is impaired in diabetic retinopathy. C57BL/6J mice and Bio-Bree
Externí odkaz:
https://doaj.org/article/86a8d53e74f94669a9dc5c48e2ffd846
Autor:
Danielle McAnally, Khandaker Siddiquee, Ahmed Gomaa, Andras Szabo, Stefan Vasile, Patrick R Maloney, Daniela B Divlianska, Satyamaheshwar Peddibhotla, Camilo J Morfa, Paul Hershberger, Rebecca Falter, Robert Williamson, David B Terry, Rafal Farjo, Anthony B Pinkerton, Xiaping Qi, Judith Quigley, Michael E Boulton, Maria B Grant, Layton H Smith
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202436 (2018)
Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The loss of vision resulting from these diseases significantly im
Externí odkaz:
https://doaj.org/article/2711b08fb0d24cb796c83d996b6a93ad
Autor:
Chunjuan Song, Sayak K Mitter, Xiaoping Qi, Eleni Beli, Haripriya V Rao, Jindong Ding, Colin S Ip, Hongmei Gu, Debra Akin, William A Dunn, Catherine Bowes Rickman, Alfred S Lewin, Maria B Grant, Michael E Boulton
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171940 (2017)
p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene expression influencing cellular fate. We studied the effect of hydrogen per
Externí odkaz:
https://doaj.org/article/4bf9aaa6427c4582993782460d6aff9c
Autor:
Harshini Chakravarthy, Eleni Beli, Svetlana Navitskaya, Sandra O'Reilly, Qi Wang, Nermin Kady, Chao Huang, Maria B Grant, Julia V Busik
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146829 (2016)
Diabetic retinopathy is a sight-threatening complication of diabetes, affecting 65% of patients after 10 years of the disease. Diabetic metabolic insult leads to chronic low-grade inflammation, retinal endothelial cell loss and inadequate vascular re
Externí odkaz:
https://doaj.org/article/4c97c784a8444914884f782d1c3ccde2
Autor:
Vaishnavi Jadhav, Qianyi Luo, James M Dominguez, Jude Al-Sabah, Brahim Chaqour, Maria B Grant, Ashay D Bhatwadekar
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163367 (2016)
Period 2-mutant mice (Per2m/m), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2m/m is associated with an increase in connective tissue growth fa
Externí odkaz:
https://doaj.org/article/6d0bb7b96a7141a6b476ef6750b437fb
Autor:
Qi Wang, Maria Tikhonenko, Svetlana N Bozack, Todd A Lydic, Lily Yan, Nicholas L Panchy, Kelly M McSorley, Matthew S Faber, Yuanqing Yan, Michael E Boulton, Maria B Grant, Julia V Busik
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95028 (2014)
Disruption of circadian regulation was recently shown to cause diabetes and metabolic disease. We have previously demonstrated that retinal lipid metabolism contributed to the development of diabetic retinopathy. The goal of this study was to determi
Externí odkaz:
https://doaj.org/article/91ddcbacf2204ebfa6b8a2bfbcf29d83
Autor:
Yagna P R Jarajapu, Sugata Hazra, Mark Segal, Sergio Li Calzi, Chandra Jadhao, Kevin Qian, Sayak K Mitter, Mohan K Raizada, Michael E Boulton, Maria B Grant
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93965 (2014)
We hypothesized that endothelial progenitor cells derived from individuals with diabetes would exhibit functional defects including inability to respond to hypoxia and altered paracrine/autocrine function that would impair the angiogenic potential of
Externí odkaz:
https://doaj.org/article/e7f09b25d3ea4ccbb11862b45c54bae8
Autor:
Yuanqing Yan, Tatiana E Salazar, James M Dominguez, Dung V Nguyen, Sergio Li Calzi, Ashay D Bhatwadekar, Xiaoping Qi, Julia V Busik, Michael E Boulton, Maria B Grant
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80029 (2013)
Dysregulation of circadian rhythmicity is identified as a key factor in disease pathogenesis. Circadian rhythmicity is controlled at both a transcriptional and post-transcriptional level suggesting the role of microRNA (miRNA) and double-stranded RNA
Externí odkaz:
https://doaj.org/article/29a7c592192a4ca69cf86dab84bfe6a8