Výsledky vyhledávání - "Maria Anzaldi"

Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator

Autor: Benedetta Pollarolo, M. Mazzei, Luis J. V. Galietta, Erika Nieddu, Maria Anzaldi, Mauro Mazzei, Silvia Schenone, Nicoletta Pedemonte

Publikováno v: Archiv der Pharmazie. 349:112-123

The phenylhydrazone RDR-1 is endowed with moderate activity as F508del-CFTR corrector; nevertheless, its simple structure enables stimulating developments in this class of correctors. Therefore, we synthesized a number of phenylhydrazones 3 by reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c3ad98e2d4821395e186f84ab70bb48
https://doi.org/10.1002/ardp.201500352

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Synthesis of short retinoidal amides related to fenretinide: antioxidant activities and differentiation-inducing ability

Autor: Alessandro Balbi, Chiara Macciò, Maria Anzaldi, Valentina Oliveri, Maurizio Viale, Patrizio Castagnola, Camillo Rosano

By a scaffold shortening strategy, a small series of retinoidal amides fenretinide (4-HPR) analogs have been synthesized from α, β-ionones and tested for their antiproliferative and differentiating activities, and antioxidant effect. The antiprolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598cb7e5378e684b935dd157aafce610
http://hdl.handle.net/20.500.11769/372512

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The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel

Autor: Luis J. V. Galietta, Erika Nieddu, Benedetta Pollarolo, Mauro Mazzei, M. Mazzei, Maria Anzaldi, Emanuela Pesce, Silvia Schenone, Nicoletta Pedemonte

Publikováno v: Future Medicinal Chemistry. 6:1857-1868

Background: The F508del mutation impairs the trafficking of CFTR from endoplasmic reticulum to plasma membrane and is responsible of a severe form of cystic fibrosis. Trafficking can be improved by small organic molecules called 'correctors'. Materia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98828f857079bccd633a54d1e6961a3f
https://doi.org/10.4155/fmc.14.118

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Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator

Autor: Erika, Nieddu, Benedetta, Pollarolo, Marco T, Mazzei, Maria, Anzaldi, Silvia, Schenone, Nicoletta, Pedemonte, Luis J V, Galietta, Mauro, Mazzei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9dd40c55159ffbeaba1a97368ee9c547
http://hdl.handle.net/11588/728871

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Antiproliferative and Proapoptotic Activities of a New Class of Pyrazole Derivatives in HL-60 Cells

Autor: Maria Bertolotto, Franco Dallegri, Luciano Ottonello, Mauro Mazzei, Maria Anzaldi, Chiara Macciò, Alessandro Balbi

Publikováno v: Chemistry & Biodiversity. 6:1674-1687

A series of N-substituted pyrazole derivatives have been synthesized and tested for their anticancer effect on the HL-60 leukaemia cell line. Four were active both in cell-growth inhibition and in inducing apoptosis. The inhibition of cell growth mai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fda3ac91ab5fd9d23d2378ce2448c7
https://doi.org/10.1002/cbdv.200800354

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Amine Exchange and Unexpected Ring-Opening Reactions of Pyranone Derivatives: Synthesis of 3-Amino-Substituted Oxonaphthopyran-carbaldehydes and Tetrahydropyrimidinethanones as New Potential Oligonucleotide Stabilization Agents

Autor: Alessandro Balbi, Gabriella Bombieri, Maria Anzaldi, Roberto Artali, Enzo Sottofattori

Publikováno v: Helvetica Chimica Acta. 85:1698-1705

3-[(3-Aminopropyl)amino]-1-oxo-1H-naphtho[2,1-b]pyran-2-carbaldehyde (10) was synthesized by nucleophilic substitution reaction of 2-(3-dimethylamino)-1-oxo-1H-naphtho[2,1-b]pyran-2-carbaldehyde (9) and the monoprotected propane-1,3-diamine. The reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f27c8b78b5cac49450442f53a2c5b90
https://doi.org/10.1002/1522-2675(200206)85:6<1698::aid-hlca1698>3.0.co

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Synthesis and antimicrobial activity of heterocyclic ionone-like derivatives

Autor: Maria Anzaldi

Publikováno v: European Journal of Medicinal Chemistry. 34:837-842

A number of heterocyclic ionone-like derivatives 5 were prepared with appropriate bifunctional reagents by one-pot cyclisation of 3-dimethylamino-5-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2,4-pentadienal 3a, which was, in turn, obtained from α-ionone wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1256e19793eb6c066db0885f5d35ee8c
https://doi.org/10.1016/s0223-5234(99)00209-3

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Synthesis of new heterocyclic derivatives of retinoids

Autor: Enzo Sottofattori, Maria Anzaldi, Alessandro Balbi

Publikováno v: Journal of Heterocyclic Chemistry. 35:1377-1380

Reaction of α- and β-ionones 1 and 2 with dialkylformamide/phosphorus oxychloride affords enamines 6 and 7 along with the expected chloro derivatives 4 and 5. Reaction of 6a with hydrazines, hydroxylamine and guanidine furnished pyrazoles, isoxazol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d92a3e5c2451d275c95b54bea2a34de
https://doi.org/10.1002/jhet.5570350626

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Simultaneous HPLC determination of multiple components in a commercial cosmetic cream

Autor: Enzo Sottofattori, Giuseppe Tonello, Alessandro Balbi, Maria Anzaldi

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 18:213-217

A high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate (I), imidazolidinylurea (II), a mixture of methyl-(III), ethyl-(IV), propyl-(V), butyl-(VI) parabens dissolved in phenoxyethanol, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77861bcd3d1c67ee481b6fcba41fb2f
https://doi.org/10.1016/s0731-7085(98)00173-3

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Asymmetric 4-Aryl-1,4-dihydropyridines Potentiate Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Autor: Mauro Mazzei, M. Mazzei, Erika Nieddu, Nicolas Vanthuyne, Christian Roussel, Luis J. V. Galietta, Michele Giampieri, Nicoletta Pedemonte, Maria Anzaldi

Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2012, 7 (10), pp.1799-1807. ⟨10.1002/cmdc.201200311⟩
ChemMedChem, 2012, 7 (10), pp.1799-1807. ⟨10.1002/cmdc.201200311⟩

Some of the genetic mutations that cause cystic fibrosis (CF) impair the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) ion channel. This defect can be corrected with pharmacological tools (potentiators) that belong to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3650d4fcb688144272882d1a51f6b174
https://hal.archives-ouvertes.fr/hal-02517561

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