Explaining Blood-Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms

Autor: Fleur M.G. Cornelissen, Greta Markert, Ghislaine Deutsch, Maria Antonara, Noa Faaij, Imke Bartelink, David Noske, W. Peter Vandertop, Andreas Bender, Bart A. Westerman

Publikováno v: Cornelissen, F M G, Markert, G, Deutsch, G, Antonara, M, Faaij, N, Bartelink, I, Noske, D, Vandertop, W P, Bender, A & Westerman, B A 2023, ' Explaining Blood-Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms ', Journal of Medicinal Chemistry, vol. 66, no. 11, pp. 7253-7267 . https://doi.org/10.1021/acs.jmedchem.2c01824
Journal of Medicinal Chemistry, 66(11), 7253-7267. American Chemical Society

The blood-brain barrier (BBB) represents a major obstacle to delivering drugs to the central nervous system (CNS), resulting in the lack of effective treatment for many CNS diseases including brain cancer. To accelerate CNS drug development, computat

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https://research.vumc.nl/en/publications/571eee73-d460-4f59-890e-91146974e9b6