Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Maria Anele Romeo"'
Autor:
Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Santarelli, Rossella Benedetti, Andrea Arena, Mara Cirone
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract PD-L1 is an immune checkpoint inhibitor, whose surface expression may be exploited by cancer cells to escape T cell-mediated immune recognition. PD-L1 expression and nuclear localization can be affected by epigenetic modifications, such as a
Externí odkaz:
https://doaj.org/article/1b77b2fbc63c4cc5bcbff0477a6c5b23
Autor:
Andrea Arena, Maria Anele Romeo, Agnese Po, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Aurelia Gaeta, Enrico De Smaele, Mara Cirone
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Post-transplant lymphoproliferative disorders (PTLD) are a group of heterogeneous diseases originating in conditions of immune deficiency, whose main driver is considered to be Epstein-Barr virus (EBV). Here, we explored the role of IRE1alph
Externí odkaz:
https://doaj.org/article/fa4b80a8095b4249ad84724846ecdcf6
Autor:
Andrea Arena, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Roberta Gonnella, Gabriella D’Orazi, Mara Cirone
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract NRF2 is a transcription factor that plays a pivotal role in carcinogenesis, also through the interaction with several pro-survival pathways. NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging
Externí odkaz:
https://doaj.org/article/15bcc674e8b744f682571bc4ce72aa38
Autor:
Rossella Benedetti, Maria Anele Romeo, Andrea Arena, Maria Saveria Gilardini Montani, Livia Di Renzo, Gabriella D’Orazi, Mara Cirone
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Colon cancer represents one of the most common and aggressive cancers in its advanced state. Among the most innovative anti-cancer approaches, the manipulation of UPR is a promising one, effective also against cancers carrying dysfunctional
Externí odkaz:
https://doaj.org/article/3bffac19e05b46b391215b80e5b46962
Autor:
Stefania Mardente, Maria Anele Romeo, Angela Asquino, Agnese Po, Maria Saveria Gilardini Montani, Mara Cirone
Publikováno v:
Viruses, Vol 15, Iss 10, p 2122 (2023)
Recent studies have shown that thyrocytes are permissive to HHV-6A infection and that the virus may contribute to the pathogenesis of autoimmune thyroiditis. Thyroid autoimmune diseases increase the risk of papillary cancer, which is not surprising c
Externí odkaz:
https://doaj.org/article/db5cba2643c346d29a1be3fb4b88b00e
Autor:
Andrea Arena, Michele Di Crosta, Roberta Gonnella, Roberta Zarrella, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D’Orazi, Mara Cirone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11598 (2023)
NFE2L2 and STAT3 are key pro-survival molecules, and thus, their targeting may represent a promising anti-cancer strategy. In this study, we found that a positive feedback loop occurred between them and provided evidence that their concomitant inhibi
Externí odkaz:
https://doaj.org/article/8e717e52ac8e42f5b7f9f8a22c52b652
Autor:
Concetta Anna Germano, Giuseppe Clemente, Antonello Storniolo, Maria Anele Romeo, Elisabetta Ferretti, Mara Cirone, Livia Di Renzo
Publikováno v:
Biology, Vol 12, Iss 5, p 676 (2023)
mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K. Here, we found that quercetin (Q) and rapamycin (Rap) inhibited P70S6K phosphorylation, partially dephosp
Externí odkaz:
https://doaj.org/article/2647b2feaf414d26b468075968d1fd67
Autor:
Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Aurelia Gaeta, Mara Cirone
Publikováno v:
Virus Research, Vol 313, Iss , Pp 198726- (2022)
HHV-6A is a neurotropic herpesvirus able to infect several CNS cells including astrocytes and primary neurons. Here we found that HHV-6A infection of astrocytoma cells, by reducing autophagy, increased ROS and induced ER stress, promoting the release
Externí odkaz:
https://doaj.org/article/752497ff60e64ad686b2f4a5d7b5cb29
Autor:
Maria Anele Romeo, Maria Saveria Gilardini Montani, Andrea Arena, Rossella Benedetti, Gabriella D’Orazi, Mara Cirone
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2489 (2022)
It has been shown that wild-type (wt)p53 inhibits oncogene c-Myc while mutant (mut)p53 may transactivate it, with an opposite behavior that frequently occurs in the crosstalk of wt or mutp53 with molecules/pathways promoting carcinogenesis. Even if i
Externí odkaz:
https://doaj.org/article/c7c2f5674f82462b815857905d89ac35
Autor:
Rossella Benedetti, Andrea Arena, Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Pankaj Trivedi, Mara Cirone
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9113 (2022)
It is emerging that targeting the adaptive functions of Unfolded Protein Response (UPR) may represent a promising anti-cancer therapeutic approach. This is particularly relevant for B-cell lymphomas, characterized by a high level of constitutive stre
Externí odkaz:
https://doaj.org/article/c1365584764e4e9aaecd3b96994df67e