Výsledky vyhledávání - "Maria Abildgaard Steffensen"

Akademický článek

Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response

Autor: Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)

Abstract Background Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes am

Externí odkaz: https://doaj.org/article/ed2d4f2a73b24896971f80d1144b8835

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Akademický článek

Neuroretinal degeneration in a mouse model of systemic chronic immune activation observed by proteomics

Autor: Asif Manzoor Khan, Maria Abildgaard Steffensen, Egle Paskeviciute, Ahmed Basim Abduljabar, Torben Lykke Sørensen, Henrik Vorum, Mogens Holst Nissen, Bent Honoré

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Blindness or vision loss due to neuroretinal and photoreceptor degeneration affects millions of individuals worldwide. In numerous neurodegenerative diseases, including age-related macular degeneration, dysregulated immune response-mediated retinal d

Externí odkaz: https://doaj.org/article/9eb2a5ecc47a468b810a5d3c8155e141

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Akademický článek

Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection

Autor: Egle Paskeviciute, Mei Chen, Heping Xu, Bent Honoré, Henrik Vorum, Torben Lykke Sørensen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Mogens Holst Nissen, Maria Abildgaard Steffensen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that a systemic

Externí odkaz: https://doaj.org/article/30457082d32b4a29a6d668c4dc46358f

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Akademický článek

Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses.

Autor: Maria Abildgaard Steffensen, Benjamin Anderschou Holbech Jensen, Peter Johannes Holst, Maria Rosaria Bassi, Jan Pravsgaard Christensen, Allan Randrup Thomsen

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34884 (2012)

Adenoviral vectors have shown a great potential for vaccine development due to their inherent ability to induce potent and protective CD8 T-cell responses. However, a critical issue regarding the use of these vectors is the existence of inhibitory im

Externí odkaz: https://doaj.org/article/093e0acc65374226bc44e73bf81cb24d

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A birch sublingual allergy immunotherapy tablet reduces rhinoconjunctivitis symptoms when exposed to birch and oak and induces IgG4 to allergens from all trees in the birch homologous group

Autor: Peter Adler Würtzen, Maria Abildgaard Steffensen, Henrik Ipsen, Brian Sonne Stage, Peter Couroux, Kaare Lund, Jakob Thomas Damkjaer, Anne Marie Salapatek

Publikováno v: Allergy

Background This randomized, double‐blind trial was conducted to determine the optimal dose for clinical efficacy of the SQ tree SLIT‐tablet. An environmental exposure chamber (EEC) was used to reduce variability of allergen exposure and allow inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae043c46fa3095a04c7703217f5d9dc
http://europepmc.org/articles/PMC6588091

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Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes : Fading protection coincides with declining CD8 T cell numbers and phenotypic changes

Autor: Maria Abildgaard Steffensen, Jan Pravsgaard Christensen, Marie Louise Jahn, Allan Randrup Thomsen

Publikováno v: Vaccine. 36:2825-2832

Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity. Extensive studies have provided important insight regarding the characteristics an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a971ec4bebdfa501fd2d208ed22040b0
https://doi.org/10.1016/j.vaccine.2018.03.080

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Co-Expression of Tumor Antigen and Interleukin-2 From an Adenoviral Vector Augments the Efficiency of Therapeutic Tumor Vaccination

Autor: Karen Nørgaard Nielsen, Benjamin A. H. Jensen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Maria Abildgaard Steffensen, Peter Johannes Holst

Publikováno v: Molecular Therapy. 22:2107-2117

We have previously shown that for the majority of antigens, adenoviral vaccines expressing the target antigen fused to the MHC associated invariant chain (Ii) induce an accelerated, augmented, and prolonged transgene-specific CD8(+) T-cell response.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ca222f53208332a26af0802133c3ac
https://doi.org/10.1038/mt.2014.130

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Priming of CD8 T Cells by Adenoviral Vectors Is Critically Dependent on B7 and Dendritic Cells but Only Partially Dependent on CD28 Ligation on CD8 T Cells

Autor: Karen Nørgaard Nielsen, Allan Randrup Thomsen, Maria Abildgaard Steffensen, Jan Pravsgaard Christensen

Publikováno v: The Journal of Immunology. 193:1223-1232

Adenoviral vectors have long been forerunners in the development of effective CD8 T cell–based vaccines; therefore, it is imperative that we understand the factors controlling the induction of robust and long-lasting transgene-specific immune respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e47ed8bee45593b4be9c39ac192c0b
https://doi.org/10.4049/jimmunol.1400197

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Adenovirus-Based Vaccine against Listeria monocytogenes: Extending the Concept of Invariant Chain Linkage

Autor: Maria Abildgaard Steffensen, Benjamin A. H. Jensen, Dirk Schlüter, Allan Randrup Thomsen, Jan Pravsgaard Christensen, Søren Tolver Jensen

Publikováno v: The Journal of Immunology. 191:4152-4164

The use of replication-deficient adenoviruses as vehicles for transfer of foreign genes offers many advantages in a vaccine setting, eliciting strong cellular immune responses involving both CD8+ and CD4+ T cells. Further improving the immunogenicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b46867110dd87b47fa663dcf4d9d132
https://doi.org/10.4049/jimmunol.1301290

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PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A

Autor: Sara R Pedersen, Ida E M Uddbäck, Jan Pravsgaard Christensen, Loulieta Nazerai, Allan Randrup Thomsen, Maria Abildgaard Steffensen

Publikováno v: Uddbäck, I E M, Steffensen, M A, Pedersen, S R, Nazerai, L, Thomsen, A R & Christensen, J P 2016, ' PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A ', Scientific Reports, vol. 6, 35033 . https://doi.org/10.1038/srep35033
Scientific Reports

Current influenza vaccines are inducing antibody-mediated immunity toward the surface proteins hemagglutinin and neuraminidase. High variability of these proteins results in costly annual evaluation and production of new vaccines, not providing prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9fb702e2565583b54d0cf8a77265c3

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