Výsledky vyhledávání - "Maria Aatonen"

Akademický článek

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

Autor: Simona Selberg, Daria Blokhina, Maria Aatonen, Pertti Koivisto, Antti Siltanen, Eero Mervaala, Esko Kankuri, Mati Karelson

Publikováno v: Cell Reports, Vol 26, Iss 13, Pp 3762-3771.e5 (2019)

Summary: Chemical modifications of RNA provide an additional, epitranscriptomic, level of control over cellular functions. N-6-methylated adenosines (m6As) are found in several types of RNA, and their amounts are regulated by methyltransferases and d

Externí odkaz: https://doaj.org/article/f46b243934c6485db7009eca7675a3c9

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Akademický článek

Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning

Autor: Lotta Kilpinen, Ulla Impola, Lotta Sankkila, Ilja Ritamo, Maria Aatonen, Sami Kilpinen, Jarno Tuimala, Leena Valmu, Jouko Levijoki, Piet Finckenberg, Pia Siljander, Esko Kankuri, Eero Mervaala, Saara Laitinen

Publikováno v: Journal of Extracellular Vesicles, Vol 2, Iss 0, Pp 1-15 (2013)

Background: Mesenchymal stromal cells (MSC) are shown to have a great therapeutic potential in many immunological disorders. Currently the therapeutic effect of MSCs is considered to be mediated via paracrine interactions with immune cells. Umbilical

Externí odkaz: https://doaj.org/article/fded3fd7175844c9823774af85ca0943

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Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

Autor: Pertti Koivisto, Esko Kankuri, Simona Selberg, Daria Blokhina, Mati Karelson, Antti Siltanen, Maria Aatonen, Eero Mervaala

Publikováno v: Cell Reports, Vol 26, Iss 13, Pp 3762-3771.e5 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20153eb89ec50a03c3bd8ee1fcca0fc
http://hdl.handle.net/10138/301542

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Cutaneous T-Cell Lymphoma (CTCL) Cell Line-Derived Extracellular Vesicles Contain HERV-W-Encoded Fusogenic Syncytin-1

Autor: François Mallet, Maria Aatonen, Kirsi Laukkanen, Mirjam Saarinen, Annika Hau, Annamari Ranki

Publikováno v: Journal of Investigative Dermatology. 140:1466-1469.e4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf33478c29de0583561b50b13e06c68d
https://doi.org/10.1016/j.jid.2019.11.021

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Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes

Autor: Vidya Velagapudi, Tuomas Mirtti, Taija af Hällström, Saara Laitinen, Olli Kallioniemi, Antti Rannikko, Maria-Elisa Nordberg, Maija Puhka, Marjo Yliperttula, Sami Valkonen, Maarit Takatalo, Maria Aatonen, Jatin Nandania, Pia Siljander

Publikováno v: Theranostics

Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from the secreting cells. So far, biomarkers for pathological conditions have been mainly searched from their protein, (mi) RNA, DNA and lipid cargo. Here, we ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30959984f343ef8c3bf5a52ecb32b2d
http://hdl.handle.net/10138/224629

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Isolation and characterization of platelet-derived extracellular vesicles

Autor: Saara Laitinen, Maria Aatonen, Tuula A. Nyman, Pia Siljander, Tiina Öhman, Mikaela Grönholm

Publikováno v: Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-15 (2014)
Journal of Extracellular Vesicles; Vol 3 (2014) incl supplements
Journal of Extracellular Vesicles

Background : Platelet-derived extracellular vesicles (EVs) participate, for example, in haemostasis, immunity and development. Most studies of platelet EVs have targeted microparticles, whereas exosomes and EV characterization under various condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73004aa43e54645158820e9d7a4a7000
http://www.journalofextracellularvesicles.net/index.php/jev/article/download/24692/34960

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Isolation of Platelet-Derived Extracellular Vesicles

Autor: Sami Valkonen, Maria Aatonen, Rienk Nieuwland, Pia Siljander, Yuana Yuana, Anita N. Böing

Publikováno v: Methods in Molecular Biology ISBN: 9781493967261

Platelets participate in several physiological functions, including hemostasis, immunity, and development. Additionally, platelets play key roles in arterial thrombosis and cancer progression. Given this plethora of functions, there is a strong inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03c4c45705bb0651ece4cafb801c853c
https://doi.org/10.1007/978-1-4939-6728-5_12

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β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

Autor: Jari Ylänne, Heikki Takala, Carl G. Gahmberg, Susanna C. Fagerholm, Maarit Takatalo, Maria Aatonen, Elisa M. Nurminen, Tiila R. Kiema, Tomas Strandin, Susanna M. Nurmi

Publikováno v: Blood. 112:1853-1862

Leukocyte integrins of the β2 family are essential for immune cell-cell adhesion. In activated cells, β2 integrins are phosphorylated on the cytoplasmic Thr758, leading to 14-3-3 protein recruitment to the β2 integrin. The mutation of this phospho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca34bb23200e71f7bd479de107520e12
https://doi.org/10.1182/blood-2007-12-127795

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Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning

Autor: Jarno Tuimala, Eero Mervaala, Ilja Ritamo, Leena Valmu, Pia Siljander, Esko Kankuri, Ulla Impola, Saara Laitinen, Sami Kilpinen, Lotta Kilpinen, Maria Aatonen, Piet Finckenberg, Jouko Levijoki, Lotta Sankkila

Publikováno v: Journal of Extracellular Vesicles; Vol 2 (2013) incl Supplements
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 2, Iss 0, Pp 1-15 (2013)

Background : Mesenchymal stromal cells (MSC) are shown to have a great therapeutic potential in many immunological disorders. Currently the therapeutic effect of MSCs is considered to be mediated via paracrine interactions with immune cells. Umbilica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3de04866538ac35ed51fbf262c0f53d
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/21927

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Integrin CD11c/CD18 α-chain phosphorylation is functionally important

Autor: Carl G. Gahmberg, Maria Aatonen, Liisa M. Uotila

Publikováno v: The Journal of biological chemistry. 288(46)

CD11c/CD18 (αXβ2, p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins, extracellular matrix proteins, and soluble ligands. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eb74f93db3da9e2df832949cd72961
https://pubmed.ncbi.nlm.nih.gov/24129562

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