Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Maria A. Soos"'
Autor:
Phillip Gorden, Andreea O. Lungu, James E. Balow, Rana Malek, Beatrice Lupsa, Robert K. Semple, A. Y. Chong, Maria A. Soos, Elaine Cochran
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:3641-3647
Background: Type B insulin resistance belongs to a class of diseases caused by an autoantibody to a cell surface receptor. Blockade of insulin action results in hyperglycemia, hypercatabolism, severe acanthosis nigricans, and hyperandrogenism in wome
Autor:
Ruth J. F. Loos, Katherine A. Fawcett, Holly E. Syddall, Allan Daly, Eleanor Wheeler, Nicholas J. Wareham, Stephen O'Rahilly, Neil Grimsey, Symeon Siniossoglou, Cyrus Cooper, Inês Barroso, Robert K. Semple, Maria A. Soos
Publikováno v:
Diabetes
OBJECTIVE— Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld mouse, and LPIN1 expression and common genetic variation were recently suggested to influence adiposity and insulin sensitivity in humans. We aimed to conduc
Autor:
Todd Schraw, Nils Halberg, Philipp E. Scherer, Nicholas J. Wareham, Jian'an Luan, Robert K. Semple, David B. Dunger, Phillip Gorden, Elaine Cochran, Stephen O'Rahilly, Maria A. Soos, Keith Burling
Publikováno v:
Diabetes. 56:1712-1717
Total plasma adiponectin and high–molecular weight (HMW) polymeric adiponectin are strongly positively correlated with insulin sensitivity. However, we have recently reported paradoxical hyperadiponectinemia in patients with severe insulin resistan
Autor:
Inês Barroso, Maria A. Soos, Jian'an Luan, Wendy Kimber, Stephen O'Rahilly, Karen Tan, Nicholas J. Wareham, Robert K. Semple
Publikováno v:
Diabetes. 56:714-719
We previously reported a family in which a heterozygous missense mutation in Akt2 led to a dominantly inherited syndrome of insulin-resistant diabetes and partial lipodystrophy. To determine whether genetic variation in AKT2 plays a broader role in h
Autor:
Jørgen Jensen, Erlend O. Brennesvik, Maria A. Soos, Ellen M. L. Engebretsen, Einar Jebens, Jérôme Ruzzin, Jonathan P. Whitehead, Stephen O'Rahilly
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 290:E154-E162
Insulin-stimulated glucose uptake and incorporation of glucose into skeletal muscle glycogen contribute to physiological regulation of blood glucose concentration. In the present study, glucose handling and insulin signaling in isolated rat muscles w
Autor:
A. Margot Umpleby, Huw Alban Davies, Carlo L. Acerini, Christian Wolfrum, Jenny C Wilson, David B. Dunger, Maria A. Soos, S Schinner, Rachel M. Williams, Justin J. Rochford, Markus Stoffel, Inês Barroso, Stella George, Sarah L. Gray, Stephen O'Rahilly, Nicholas J. Wareham, Alan J. Schafer, Peter R. Murgatroyd, David Barford
Publikováno v:
Science. 304:1325-1328
Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we describe a mutation in the gene encoding the protein kinase AKT2/PKBβ in a family that shows
Autor:
Alan J. Schafer, Maria A. Soos, Antonio Vidal-Puig, Aline Meirhaeghe, Jian'an Luan, Stephen O'Rahilly, Lisa Logie, Giles S.H. Yeo, Nicholas J. Wareham, Inês Barroso, Matthias Laudes
Publikováno v:
Diabetes. 53:842-846
The transcription factor sterol regulatory element binding protein (SREBP)-1c is intimately involved in the regulation of lipid and glucose metabolism. To investigate whether mutations in this gene might contribute to insulin resistance, we screened
Autor:
David B. Savage, Gudrun Ihrke, Maria A. Soos, E. Louise Thomas, K. Meeran, Inês Barroso, Antonio Vidal-Puig, Aline Meirhaeghe, Maura Agostini, Jian'an Luan, Odelia Rajanayagam, Jimmy D. Bell, Stephen O'Rahilly, Dirk Berger, Richard J. Ross, Anne-Helen Harding, Alan J. Schafer, Mark Gurnell, Nicholas J. Wareham, V. Krishna K. Chatterjee, Stella George
Publikováno v:
Nature Genetics. 31:379-384
Impaired insulin action is a key feature of type 2 diabetes and is also found, to a more extreme degree, in familial syndromes of insulin resistance. Although inherited susceptibility to insulin resistance may involve the interplay of several genetic
Class II Phosphoinositide 3-Kinase Is Activated by Insulin but Not by Contraction in Skeletal Muscle
Autor:
Jørgen Jensen, Maria A. Soos, Stephen O'Rahilly, Peter R. Shepherd, Jonathan P. Whitehead, R.A. Brown
Publikováno v:
Archives of Biochemistry and Biophysics. 396:244-248
While the role of the class IA phosphoinositide 3-kinase (PI 3-kinase) in insulin signaling is well established, little is known about the role of the class II PI 3-kinases. We show that insulin stimulation of intact rat soleus and epitrochlearis mus
Autor:
Kathy H. Surinya, K. Siddle, Diane L. Cope, L. Molina, Maria A. Soos, C. A. Niesler, Birgitte Ursø
Publikováno v:
Biochemical Society Transactions. 29:513-525
The physiological roles of insulin and insulin-like growth factors (IGFs) are distinct, with insulin acting to regulate cellular uptake and metabolism of fuels, whereas IGFs promote cell growth, survival and differentiation. The only components of si