A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging

Autor: Lucia Maccioni, Carranza Mellana Michelle, Ludovica Brusaferri, Erica Silvestri, Alessandra Bertoldo, Julia J. Schubert, Maria A. Nettis, Valeria Mondelli, Oliver Howes, Federico E. Turkheimer, Michel Bottlaender, Benedetta Bodini, Bruno Stankoff, Marco L. Loggia, Mattia Veronese

Publikováno v: Frontiers in Neuroscience, Vol 18 (2024)

IntroductionRecent evidence suggests the blood-to-brain influx rate (K1) in TSPO PET imaging as a promising biomarker of blood–brain barrier (BBB) permeability alterations commonly associated with peripheral inflammation and heightened immune activ

Externí odkaz: https://doaj.org/article/760dc5ff829c4c71a2186e6159860f14

Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression

Autor: Noha Althubaity, Julia Schubert, Daniel Martins, Tayyabah Yousaf, Maria A. Nettis, Valeria Mondelli, Carmine Pariante, Neil A. Harrison, Edward T. Bullmore, Danai Dima, Federico E. Turkheimer, Mattia Veronese

Publikováno v: NeuroImage: Clinical, Vol 33, Iss , Pp 102926- (2022)

Background: Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role in the interaction between the central and peripheral inflammation. Here we aimed to investigate CP volume alterations in depres

Externí odkaz: https://doaj.org/article/e11a9a6028d641c2b7202406cfdc0559

The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels

Autor: Neil A. Harrison, Jonathan Cavanagh, Carmine M. Pariante, Giulia Lombardo, Melisa Kose, Naghmeh Nikkheslat, Daniela Enache, Courtney Worrell, Anna McLaughlin, Edward T. Bullmore, Nicole Mariani, Philip J. Cowen, Maria A. Nettis, Zuzanna Zajkowska, Caitlin Hastings, Linda Pointon, Valeria Mondelli

Publikováno v: BASE-Bielefeld Academic Search Engine

BackgroundDepression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and abnormal cortisol levels.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5305b7a51124929c3944529d3fc480
https://www.repository.cam.ac.uk/handle/1810/318092

Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients: implications for inflammation and depression

Autor: Oliver Cousins, Federico Turkheimer, Mattia Veronese, Valeria Mondelli, Noha Althubaity, Carmine M. Pariante, Danai Dima, Edward T. Bullmore, Maria A. Nettis, Julia Schubert

Publikováno v: Turkheimer, F E, Althubaity, N, Schubert, J, Nettis, M A, Cousins, O, Dima, D, Mondelli, V, Bullmore, E T, Pariante, C & Veronese, M 2021, ' Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients : implications for inflammation and depression ', Brain, Behavior, and Immunity, vol. 91, pp. 487-497 . https://doi.org/10.1016/j.bbi.2020.10.025

The relationship between peripheral and central immunity and how these ultimately may cause depressed behaviour has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b9758c88b05e2211695f88132525a6
https://doi.org/10.1016/j.bbi.2020.10.025

Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia

Autor: Saeed Farooq, Miriam Hattle, Paola Dazzan, Tom Kingstone, Olesya Ajnakina, David Shiers, Maria Antonietta Nettis, Andrew Lawrence, Richard D. Riley, Danielle A. van der Windt

Publikováno v: medRxiv

IntroductionTreatment Resistant Schizophrenia (TRS) is associated with significant impairment of functioning and high treatment costs. Identification of patients at high risk of TRS at their initial diagnosis may significantly improve clinical outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9c4e42de0ac1ee8def977f87531263
https://doi.org/10.1101/2022.02.15.22270460