Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Maria A. Missinato"'
Autor:
Maria A. Missinato, Sean Murphy, Michaela Lynott, Michael S. Yu, Anaïs Kervadec, Yu-Ling Chang, Suraj Kannan, Mafalda Loreti, Christopher Lee, Prashila Amatya, Hiroshi Tanaka, Chun-Teng Huang, Pier Lorenzo Puri, Chulan Kwon, Peter D. Adams, Li Qian, Alessandra Sacco, Peter Andersen, Alexandre R. Colas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Transdifferentiation has been proposed as an approach for regenerative medicine, but the mechanisms that safeguard cell identity are not well established. Here they identify transcription factors that oppose transdifferentiation and show that knockdo
Externí odkaz:
https://doaj.org/article/20fe073154364337abcffbba8fef58fe
Autor:
Lauren Brilli Skvarca, Hwa In Han, Eugenel B. Espiritu, Maria A. Missinato, Elizabeth R. Rochon, Michael D. McDaniels, Abha S. Bais, Beth L. Roman, Joshua S. Waxman, Simon C. Watkins, Alan J. Davidson, Michael Tsang, Neil A. Hukriede
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 4 (2019)
Acute kidney injury (AKI) is a serious disorder for which there are limited treatment options. Following injury, native nephrons display limited regenerative capabilities, relying on the dedifferentiation and proliferation of renal tubular epithelial
Externí odkaz:
https://doaj.org/article/e07c8956261544919ae06d1bac3c4d12
Autor:
Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer
Publikováno v:
eLife, Vol 9 (2020)
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole-g
Externí odkaz:
https://doaj.org/article/7b02a3ed48a047c4bd8549ffe623c1c1
Autor:
Daniel A. Zuppo, Maria A. Missinato, Lucas Santana-Santos, Guang Li, Panayiotis V. Benos, Michael Tsang
Publikováno v:
Development. 150
The regenerative capacity of the mammalian heart is poor, with one potential reason being that adult cardiomyocytes cannot proliferate at sufficient levels to replace lost tissue. During development and neonatal stages, cardiomyocytes can successfull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f4df435ae4c7ae05c326726163a1050
https://doi.org/10.1242/dev.201163
https://doi.org/10.1242/dev.201163
Autor:
Tanja Nielsen, Anaïs Kervadec, Maria A. Missinato, Michaela Lynott, Xin-Xin I. Zeng, Marie Berenguer, Stanley M. Walls, Analyne Schroeder, Katja Birker, Greg Duester, Paul Grossfeld, Timothy J. Nelson, Timothy M. Olson, Karen Ocorr, Rolf Bodmer, Jeanne L. Theis, Georg Vogler, Alexandre R. Colas
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d332e5aa3bd31779e9bf74cf83b82f
https://doi.org/10.1101/2022.07.01.22277112
https://doi.org/10.1101/2022.07.01.22277112
Autor:
Daniel A. Zuppo, Maria A. Missinato, Lucas Santana-Santos, Guang Li, Panayiotis V. Benos, Michael Tsang
The regenerative capacity of the mammalian heart is poor with one potential reason being that adult cardiomyocytes cannot proliferate at sufficient levels to replace lost tissue. During development and early neonatal stages, cardiomyocytes can succes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0100d536f1a6b447075eae3eaa77d1db
https://doi.org/10.1101/2022.06.22.497073
https://doi.org/10.1101/2022.06.22.497073
Autor:
Katja Birker, Natalie J. Kirkland, Jeanne L. Theis, Zachary C. Fogarty, Maria Azzurra Missinato, Sreehari Kalvakuri, Paul Grossfeld, Adam J. Engler, Karen Ocorr, Timothy J. Nelson, Alexandre R. Colas, Timothy M. Olson, Georg Vogler, Rolf Bodmer
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We therefore performed whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de9615e5fb84c5ca1ef68ab72c2a613
https://doi.org/10.1101/2022.06.13.22276366
https://doi.org/10.1101/2022.06.13.22276366
Autor:
Jesús Tejero, Mark T. Gladwin, Maria A. Missinato, Michael Tsang, Jianmin Xue, Paola Corti, Elizabeth R. Rochon
Publikováno v:
Antioxid Redox Signal
Aims: Nitrite is reduced to nitric oxide (NO) under physiological and pathological hypoxic conditions to modulate angiogenesis and improve ischemia–reperfusion injury. Although adult mammals lack the ability to regenerate the heart after injury, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd03a409b9aea368934d804317ddc95
https://doi.org/10.1089/ars.2018.7687
https://doi.org/10.1089/ars.2018.7687
Autor:
Peter Andersen, Li Qian, Maria A. Missinato, Sean Murphy, Prashila Amatya, Christopher Lee, Alessandra Sacco, Michaela Lynott, Suraj Kannan, Alexandre R. Colas, Peter D. Adams, Pier Lorenzo Puri, Chun-Teng Huang, Anaïs Kervadec, Chulan Kwon, Hiroshi Tanaka, Michael S. Yu, Yu-Ling Chang, Mafalda Loreti
The comprehensive characterization of mechanisms safeguarding cell fate identity in differentiated cells is crucial for 1) our understanding of how differentiation is maintained in healthy tissues or misregulated in disease states and 2) to improve o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0953cb35f0c4219e6b07b959021186bb
https://doi.org/10.1101/2021.06.28.450261
https://doi.org/10.1101/2021.06.28.450261
Publikováno v:
Dev Dyn
Background Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardiomyocyte genetic ablation. Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c11a2a6dfc8cfc86340bb3fecb0d45
https://europepmc.org/articles/PMC8249307/
https://europepmc.org/articles/PMC8249307/