Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maria A T Groves"'
Autor:
Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor
Externí odkaz:
https://doaj.org/article/e9b2ccb330b0476b8cb004d93c4045cc
Autor:
Maria A T Groves, Denice T Y Chan
Publikováno v:
Emerging Topics in Life Sciences
Affinity maturation is a key technique in protein engineering which is used to improve affinity and binding interactions in vitro, a process often required to fulfil the therapeutic potential of antibodies. There are many available display technologi
Autor:
Ellen Gowans, Stuart W. Haynes, Mark D. Carr, Stephanie Ryman, Maria A T Groves, Daniel Burschowsky, Tristan J Vaughan, Alexandra Addyman, Vincenzo Cerundolo, Agata Diamandakis, Chitra Seewooruthun, Yoko Shibata, Louise H. Slater, Sarah V. Holt, Denice T Y Chan, Sebastian Fiedler, Jessica Whitehouse, Robert W. Wilkinson, Lesley Jenkinson, Mark Austin, Michelle Barnard
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We describe an antibody optimization strategy that seeks to overcome the restrictive nature of existing affinity-maturation methods, by rapidly exploring a vast sequence space in an unbiased manner through application of PCR techniques a
Autor:
Claire L Meek, Geoffrey P. Roberts, Tristan J Vaughan, Richard G. Kay, Florent Serge Dye, Deborah A. Goldspink, Benjamin G. Challis, Pierre Larraufie, Maria A T Groves, Fiona M. Gribble, Frank Reimann, Franco Ferraro, Stephen J. Middleton, Juraj Rievaj, Richard H. Hardwick, Jennifer L. Percival-Alwyn, Tamana Darwish, Stephen O'Rahilly
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52049-0⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52049-0⟩
Guanylin, a peptide implicated in regulation of intestinal fluid secretion, is expressed in the mucosa, but the exact cellular origin remains controversial. In a new transgenic mouse model fluorescent reporter protein expression driven by the proguan
Autor:
Jane Hughes, Iain Chessell, Arjan Snijder, Peter E. Thornton, Maria A T Groves, Bojana Popovic, James Button, Claire Dobson, Tristan J Vaughan, Bruck Taddese, Darren J. Schofield, Trevor Wilkinson, Wendy A Williams, Ling Huang, Jon P. Hatcher, Clare A. Jones, Yoko Shibata, George Thom, Bhupinder Dosanjh, Andy Billinton, Carl I Webster, John E. Linley
Publikováno v:
Pain. 160:1989-2003
P2X4 is a ligand-gated ion channel implicated in neuropathic pain. Drug discovery efforts targeting P2X4 have been unsuccessful largely because of the difficulty in engineering specificity and selectivity. Here, we describe for the first time the gen
Autor:
Kelly McGlinchey, Scott A. Hammond, John Hood, Ross Stewart, Grace Adjei, Weimin Chen, John Andrews, Darren J. Schofield, Robert W. Wilkinson, Maria A T Groves, Leslie Wetzel, Jennifer L. Percival-Alwyn, Michael Oberst, Mateusz Rytelewski, LeeAnn Machiesky, Andrew Leinster, Claire Dobson, Nadia Luheshi, Raymond Rothstein, Michelle Morrow, Amanda Watkins
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Autor:
Jessica Whitehouse, Mark D. Carr, Lesley Jenkinson, Daniel Burschowsky, Pooja Sharma, Teresa Kaserer, Mark Austin, Yoko Shibata, Michelle Barnard, Sebastian Fiedler, Alexandra Addyman, Denice T Y Chan, Uzi Gileadi, Tristan J Vaughan, Vincenzo Cerundolo, Stuart W. Haynes, Andreas V. Hadjinicolaou, Robert W. Wilkinson, Nadia Luheshi, Ellen Gowans, Stephanie Ryman, Chitra Seewooruthun, Louise H. Slater, Maria A T Groves, Sarah V. Holt, Agata Diamandakis
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor
Autor:
Denice Y Chan, Lesley Jenkinson, Mark Austin, Maria A T Groves, Lisa Ruff, Sarah V. Holt, Stuart W. Haynes, Richard J. Gilbertson
Publikováno v:
Neuro-Oncology
Ependymomas account for 10% of paediatric brain tumours and arise in the ventricular walls of the central nervous system. Ependymomas were previously classified as one tumour type and all patients received similar treatment. However, recent genomic s