Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study

Autor: Audrey Low, Maria A. Prats-Sedano, Elizabeth McKiernan, Stephen F. Carter, James D. Stefaniak, Stefania Nannoni, Li Su, Maria-Eleni Dounavi, Graciela Muniz-Terrera, Karen Ritchie, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare Mackay, Ivan Koychev, Craig W. Ritchie, Hugh S. Markus, John T. O’Brien

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2022)

Abstract Background Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited to older cohorts wherein pathologies of both dementia (e.g. amyloid) and SVD (e.g. white mat

Externí odkaz: https://doaj.org/article/818fa79205274e5c84710a0024322785

CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study

Autor: Audrey Low, Maria A Prats-Sedano, James D Stefaniak, Elizabeth Frances McKiernan, Stephen F Carter, Maria-Eleni Douvani, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz, Karen Ritchie, Craig W Ritchie, Hugh S Markus, John Tiernan O'Brien

Publikováno v: Low, A, Prats-sedano, M A, Stefaniak, J D, Mckiernan, E F, Carter, S F, Douvani, M, Mak, E, Su, L, Stupart, O, Muniz, G, Ritchie, K, Ritchie, C W, Markus, H S & O'brien, J T 2022, ' CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study ', Journal of Neurology, Neurosurgery & Psychiatry, pp. jnnp-2021-327462 . https://doi.org/10.1136/jnnp-2021-327462

BACKGROUND: Markers of cerebrovascular disease are common in dementia, and may be present before dementia onset. However, their clinical relevance in midlife adults at risk of future dementia remains unclear. We investigated whether the Cardiovascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce44cbeda85f938f1972b85050a5dd

Intact pain modulation through manipulation of controllability and expectations in aging

Autor: Marian van der Meulen, Maria Angeles Prats-Sedano, Pedro Montoya, Carolina Sitges, Juan L. Terrasa, Ana M. González-Roldán, Fernand Anton

Publikováno v: European journal of pain (London, England)REFERENCES. 25(7)

Background Pain expectation and controllability can modulate pain processing. However, little is known about age-related effects on these cognitive factors involved in pain control. This study assessed age-related brain changes associated with pain e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0794a3577938df026ed1bb6cb94691dd
https://pubmed.ncbi.nlm.nih.gov/33666318