Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Maria A Miteva"'
Autor:
Elodie Goldwaser, Catherine Laurent, Nathalie Lagarde, Sylvie Fabrega, Laure Nay, Bruno O Villoutreix, Christian Jelsch, Arnaud B Nicot, Marie-Anne Loriot, Maria A Miteva
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009820 (2022)
Cytochrome P450 2C9 (CYP2C9) is a major drug-metabolizing enzyme that represents 20% of the hepatic CYPs and is responsible for the metabolism of 15% of drugs. A general concern in drug discovery is to avoid the inhibition of CYP leading to toxic dru
Externí odkaz:
https://doaj.org/article/676c54c1293346ed92495073dc34d425
Publikováno v:
ACS Omega, Vol 9, Iss 40, Pp 41334-41342 (2024)
Externí odkaz:
https://doaj.org/article/35824a8215cd4781ad43e4591d1c2b40
Autor:
Maxime Louet, Céline M Labbé, Charline Fagnen, Cassiano M Aono, Paula Homem-de-Mello, Bruno O Villoutreix, Maria A Miteva
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197249 (2018)
Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs. The allelic variant CYP2C9*30 (A477T) is associated to diminished response to the antihypertensive effects of the prodrug losartan and affected metabolism of other
Externí odkaz:
https://doaj.org/article/893648c839de4dbe91106c294712cc81
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2548-2564 (2024)
P-glycoprotein (P-gp) plays a crucial role in cellular detoxification and drug efflux processes, transitioning between inward-facing (IF) open, occluded, and outward-facing (OF) states to facilitate substrate transport. Its role is critical in cancer
Externí odkaz:
https://doaj.org/article/a89cc4aff34b495182c4b60c28beb7de
Autor:
Desislav G. Tomov, Boryana A. Levterova, Valentina N. Mihailova, Dimitar M. Troev, Maria Z. Miteva, Yordanka I. Uzunova, Maria M. Orbetzova
Publikováno v:
Endocrine and Metabolic Science, Vol 16, Iss , Pp 100195- (2024)
The etiology of Hashimoto's thyroiditis is still unclear. Genetic predisposition and the effects of various environmental factors are discussed. The present article is a systematic review of publications on the occurrence and development of this dise
Externí odkaz:
https://doaj.org/article/deb0b170537f4851ade43071df574b1b
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110884 (2014)
Snyder-Robinson Syndrome (SRS) is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS), which functions as a homo-dimer. The malfunctioning of SMS in SRS patients is associated with severa
Externí odkaz:
https://doaj.org/article/a5951430f43d43a797c008997e6b8250
Autor:
Virginie Y Martiny, Pablo Carbonell, David Lagorce, Bruno O Villoutreix, Gautier Moroy, Maria A Miteva
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73587 (2013)
Drug metabolizing enzymes play a key role in the metabolism, elimination and detoxification of xenobiotics, drugs and endogenous molecules. While their principal role is to detoxify organisms by modifying compounds, such as pollutants or drugs, for a
Externí odkaz:
https://doaj.org/article/13024b9923fb480c877f386bda11f813
Autor:
Stéphanie Pérot, Leslie Regad, Christelle Reynès, Olivier Spérandio, Maria A Miteva, Bruno O Villoutreix, Anne-Claude Camproux
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63730 (2013)
Pockets are today at the cornerstones of modern drug discovery projects and at the crossroad of several research fields, from structural biology to mathematical modeling. Being able to predict if a small molecule could bind to one or more protein tar
Externí odkaz:
https://doaj.org/article/a15bd0bd31af482b8f74019b9e091162
Autor:
Bruno O Villoutreix, Guillaume Laconde, David Lagorce, Pierre Martineau, Maria A Miteva, Piona Dariavach
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21117 (2011)
In the past decade, the spleen tyrosine kinase (Syk) has shown a high potential for the discovery of new treatments for inflammatory and autoimmune disorders. Pharmacological inhibitors of Syk catalytic site bearing therapeutic potential have been de
Externí odkaz:
https://doaj.org/article/711b3f3deb274d79b99f2c45ff57174c
Autor:
Desislav G. Tomov, Boryana A. Levterova, Dimitar M. Troev, Maria Z. Miteva, Valentina N. Mihaylova, Yordanka I. Uzunova, Vidka V. Divarova, Maria M. Orbetzova
Publikováno v:
Folia Medica, Vol 65, Iss 2, Pp 199-206 (2023)
Introduction: Adipose tissue is immunologically and hormonally active, and these effects are mediated largely by adipocytokines. Thyroid hormones regulate metabolism and organ function, and Hashimoto’s thyroiditis (HT) is the most common autoimmune
Externí odkaz:
https://doaj.org/article/12414e2507d5406d85336557f52719c7