Zobrazeno 1 - 10
of 429
pro vyhledávání: '"Maria A Juliano"'
Autor:
Felipe J Fuzita, Martijn W H Pinkse, José S L Patane, Maria A Juliano, Peter D E M Verhaert, Adriana R Lopes
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123841 (2015)
Scorpions are among the oldest terrestrial arthropods and they have passed through small morphological changes during their evolutionary history on land. They are efficient predators capable of capturing and consuming large preys and due to envenomat
Externí odkaz:
https://doaj.org/article/d7c8fa73e283444d9c995aa042d0a5e9
Autor:
Felipe V Pereira, Carla A Ferreira-Guimarães, Thaysa Paschoalin, Jorge A B Scutti, Filipe M Melo, Luis S Silva, Amanda C L Melo, Priscila Silva, Manoela Tiago, Alisson L Matsuo, Luiz Juliano, Maria A Juliano, Adriana K Carmona, Luiz R Travassos, Elaine G Rodrigues
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e96141 (2014)
The increased incidence, high rates of mortality and few effective means of treatment of malignant melanoma, stimulate the search for new anti-tumor agents and therapeutic targets to control this deadly metastatic disease. In the present work the ant
Externí odkaz:
https://doaj.org/article/563b1984aa4c4ae0930e2e5280469aba
Autor:
Arthur A Nery, Margaret H Magdesian, Cleber A Trujillo, Luciana B Sathler, Maria A Juliano, Luiz Juliano, Henning Ulrich, Sergio T Ferreira
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67194 (2013)
Alzheimer's disease (AD) is characterized by brain accumulation of the neurotoxic amyloid-β peptide (Aβ) and by loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs). Recent evidence indicates that memory loss and cognitive dec
Externí odkaz:
https://doaj.org/article/ab41dddde33e43f2a52a5bf40dc26ccf
Autor:
Emidio Beraldo-Neto, Fernanda Cardoso Amador, Karolina Rosa Fernandes, Giselle Zenker Justo, José Thalles Lacerda, Maria A. Juliano
Publikováno v:
Cells, Vol 13, Iss 17, p 1427 (2024)
The Lucena 1 cell line, derived from the human chronic myeloid leukemia cell line K562 under selective pressure of vincristine supplementation, exhibits multidrug resistance (MDR). This study aims to explore and elucidate the underlying mechanisms dr
Externí odkaz:
https://doaj.org/article/2f04c0b467184ff58f1594a6029f2e34
Autor:
Eun Suk Song, Manana Melikishvili, Michael G Fried, Maria A Juliano, Luiz Juliano, David W Rodgers, Louis B Hersh
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46790 (2012)
Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme w
Externí odkaz:
https://doaj.org/article/96dae104c9384c608ee2aae9d12520ab
Autor:
Gabriel L C Nunes, Alyne Simões, Fábio H Dyszy, Claudio S Shida, Maria A Juliano, Luiz Juliano, Tarsis F Gesteira, Helena B Nader, Gillian Murphy, Alain F Chaffotte, Michel E Goldberg, Ivarne L S Tersariol, Paulo C Almeida
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21525 (2011)
Heparin has been shown to regulate human neutrophil elastase (HNE) activity. We have assessed the regulatory effect of heparin on Tissue Inhibitor of Metalloproteases-1 [TIMP-1] hydrolysis by HNE employing the recombinant form of TIMP-1 and correlate
Externí odkaz:
https://doaj.org/article/afc48b67b6e64ee1ad314b993234f385
Autor:
Marcelo Y Icimoto, Nilana M Barros, Juliana C Ferreira, Marcelo F Marcondes, Douglas Andrade, Mauricio F Machado, Maria A Juliano, Wagner A Júdice, Luiz Juliano, Vitor Oliveira
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24545 (2011)
The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of proh
Externí odkaz:
https://doaj.org/article/ab2d11b8c52d441baf5e284bb94ecf81
Autor:
Nicholas Noinaj, Sonia K Bhasin, Eun Suk Song, Kirsten E Scoggin, Maria A Juliano, Luiz Juliano, Louis B Hersh, David W Rodgers
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20864 (2011)
Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domain
Externí odkaz:
https://doaj.org/article/8edf4ef80c394c65aa9c037723daeca9
Role of GP82 in the selective binding to gastric mucin during oral infection with Trypanosoma cruzi.
Autor:
Daniela I Staquicini, Rafael M Martins, Silene Macedo, Gisela R S Sasso, Vanessa D Atayde, Maria A Juliano, Nobuko Yoshida
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 3, p e613 (2010)
Oral infection by Trypanosoma cruzi has been the primary cause of recent outbreaks of acute Chagas' diseases. This route of infection may involve selective binding of the metacyclic trypomastigote surface molecule gp82 to gastric mucin as a first ste
Externí odkaz:
https://doaj.org/article/11093815a5094c34917b0745a29e1a97
Autor:
Luciano Polonelli, José Pontón, Natalia Elguezabal, María Dolores Moragues, Claudio Casoli, Elisabetta Pilotti, Paola Ronzi, Andrey S Dobroff, Elaine G Rodrigues, Maria A Juliano, Domenico Leonardo Maffei, Walter Magliani, Stefania Conti, Luiz R Travassos
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2371 (2008)
BACKGROUND: Complementarity-determining regions (CDRs) are immunoglobulin (Ig) hypervariable domains that determine specific antibody (Ab) binding. We have shown that synthetic CDR-related peptides and many decapeptides spanning the variable region o
Externí odkaz:
https://doaj.org/article/0736621ece83417caa1106c4bdef1d7c