Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids.

Autor: Cristina E Rodríguez, Sara I Reidel, Elisa D Bal de Kier Joffé, Maria A Jasnis, Gabriel L Fiszman

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0137920 (2015)

Multicellular tumor spheroids represent a 3D in vitro model that mimics solid tumor essential properties including assembly and development of extracellular matrix and nutrient, oxygen and proliferation gradients. In the present study, we analyze the

Externí odkaz: https://doaj.org/article/35a404a3c41846ec9c8f2e29ee2440da

Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids

Autor: Elisa Bal de Kier Joffé, Gabriel L. Fiszman, Maria A. Jasnis, Cristina E. Rodríguez, Sara I. Reidel

Publikováno v: PLoS ONE
PLoS ONE, 10(9)
Repositorio Institucional del Instituto Nacional de Tecnología Industrial (INTI)
Instituto Nacional de Tecnología Industrial
instacron:INTI
PLoS ONE, Vol 10, Iss 9, p e0137920 (2015)

Multicellular tumor spheroids represent a 3D in vitro model that mimics solid tumor essential properties including assembly and development of extracellular matrix and nutrient, oxygen and proliferation gradients. In the present study, we analyze the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968f549634b4b5691af3cf0e103b806e
https://pubmed.ncbi.nlm.nih.gov/26360292

Different Mechanisms Lead to the Angiogenic Process Induced by Three Adenocarcinoma Cell Lines

Autor: María Elena Sales, Laura Elizabeth Rimmaudo, Tomomi Gotoh, Eulalia de la Torre, Maria A. Jasnis, Alejandro Español, Davel L, Eugenia Sacerdote de Lustig, María Laura Ribeiro

Publikováno v: Angiogenesis. 7:45-51

Neoangiogenesis is essential for tumor and metastasis growth, but this complex process does not follow the same activation pathway, at least in tumor cell lines originated from different murine mammary adenocarcinomas. LMM3 cells were the most potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b056c6ae6ee6a706bb6a6e24bf1713
https://doi.org/10.1023/b:agen.0000037329.45326.a8

Lymphocyte–Induced Angiogenesis: Effect of Different Antigenic Stimuli

Autor: Davel L, Maria A. Jasnis

Publikováno v: Oncology. 52:226-229

It is known that tumor cells activate spleen cells to induce an angiogenic response. In this report we studied whether different antigenic stimuli, other than tumor cells, were able to activate spleen lymphocytes to induce angiogenesis in syngeneic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2b1b052c6b1ad6f175dc7e37199fe0
https://doi.org/10.1159/000227462

Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer

Autor: Gabriel L. Fiszman, Maria A. Jasnis

Publikováno v: International Journal of Breast Cancer, Vol 2011 (2011)
International Journal of Breast Cancer

The epidermal growth factor receptor 2 (HER2) is a tyrosine kinase overexpressed in nearly 20% to 25% of invasive breast cancers. Trastuzumab is a humanized monoclonal antibody that targets HER2. The majority of patients with metastatic breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115bc288bb270c486cddd91eba11f5da
https://doaj.org/article/5df84d1599804d1ab40c36069f7aac39