Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Maria A, Lehn"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Age-associated microglial dysfunction contributes to the accumulation of amyloid-β (Aβ) plaques in Alzheimer’s disease. Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few
Externí odkaz:
https://doaj.org/article/155b2661eb834da5aff628b3216a5b65
Autor:
Maria A Lehn, Trisha M Wise-Draper, Shuchi Gulati, Vinita Takiar, Sarah Palackdharry, Mario Medvedovic, Timothy Stone, Joseph Curry, Vidhya Karivedu, McKenzie Crist, Benyamin Yaniv, Michael Borchers, Bethany Fuhrman, Audrey Crago, Ubaldo Martinez-Outschoorn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial (NCT023
Externí odkaz:
https://doaj.org/article/d5e39b30e67c484baead80341faf7c76
Autor:
Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. Qualls
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens. Mycobacterium tuberculosis (Mtb), one of the most virulent intracellular bacterial pathogens known to man, infects and resides within macrophages. While macroph
Externí odkaz:
https://doaj.org/article/b6fbae7edb794379b09f502c787ed320
Autor:
Laura Conforti, Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is an immunotherapy agent currently approved for metastatic HNSCC and curati
Externí odkaz:
https://doaj.org/article/65aba8cacdf74f5d84b824a04f706c53
Autor:
McKenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M Wise-Draper
Publikováno v:
Journal for immunotherapy of cancer, vol 10, iss 11
BackgroundMetformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial (NCT0232
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c43444f38b8f6ecfbbaceef07876ed
https://escholarship.org/uc/item/24s2388k
https://escholarship.org/uc/item/24s2388k
Age-associated microglial dysfunction contributes to the accumulation of amyloid-β (Aβ) plaques in Alzheimer’s disease. Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few have exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e25becbdb6a4d200969b685923a294
https://doi.org/10.21203/rs.3.rs-1720794/v1
https://doi.org/10.21203/rs.3.rs-1720794/v1
Autor:
Hannah S, Newton, Vaibhavkumar S, Gawali, Ameet A, Chimote, Maria A, Lehn, Sarah M, Palackdharry, Benjamin H, Hinrichs, Roman, Jandarov, David, Hildeman, Edith M, Janssen, Trisha M, Wise-Draper, Laura, Conforti
Publikováno v:
Journal for Immunotherapy of Cancer
Background Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is an immunotherapy agent currently approved for metastatic HNSCC and curati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b98b2810e38704366ffbeae0f4871f5
https://pubmed.ncbi.nlm.nih.gov/33060146
https://pubmed.ncbi.nlm.nih.gov/33060146
Autor:
Vaibhavkumar S. Gawali, Sarah Palackdharry, Maria A. Lehn, David A. Hildeman, Ameet A. Chimote, Roman Jandarov, Hannah S. Newton, Trisha Wise-Draper, Benjamin H. Hinrichs, Laura Conforti, Edith M Janssen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundImmunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is an immunotherapy agent currently approved for metastatic HNSCC and curativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b21e61a6d872ae1993e75819c255502
https://jitc.bmj.com/content/8/2/e000844.full
https://jitc.bmj.com/content/8/2/e000844.full
Autor:
Edith M Janssen, Sara Szabo, Rachel Cantrell, Kasper Hoebe, Laura Conforti, Maria A. Lehn, Trisha Wise-Draper, Kristin Lampe, Laura Agresta, Cassandra M. Hennies
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundDeveloping novel strategies to overcome the immunosuppressive tumor microenvironment is a critically important area of cancer therapy research. Here, we assess the therapeutic potential of CD244 (2B4/signaling lymphocyte activation molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c793b40053cc4863fc22adfff9bbdd8
http://europepmc.org/articles/PMC7174077
http://europepmc.org/articles/PMC7174077
Autor:
Kasper Hoebe, Edith M. Janssen, Cassandra M. Hennies, Maria A. Lehn, Rachel Cantrell, Kristin Lampe, Jared Klarquist
Publikováno v:
Immunohorizons
Myriad studies have linked type I IFN to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). Although increased levels of type I IFN are found in patients with SLE, and IFN blockade ameliorates disease in many mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15c5ffeaa5d1c48d8170573630b281f
https://pubmed.ncbi.nlm.nih.gov/32161059
https://pubmed.ncbi.nlm.nih.gov/32161059