Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Maria Velinova"'
Autor:
Ewa Gatlik, Beata Mehes, Emilie Voltz, Ulrike Sommer, Elaine Tritto, Giulia Lestini, Xiaoxi Liu, Parasar Pal, Maria Velinova, Wiliam S. Denney, Yunlin Fu, Anthony Opipari, Dennis Dean, Guido Junge
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract This first‐in‐human study evaluated the safety, tolerability, single‐ and multiple‐dose pharmacokinetic profiles with dietary influence, and pharmacodynamics (PD) of DFV890, an oral NLRP3 inhibitor, in healthy participants. In total,
Externí odkaz:
https://doaj.org/article/544f9b79ee9a4b83b08ad5aa687ef191
Autor:
Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud, Janneke van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, Javed Akram, Ravi K. Amaravadi, Derek C. Angus, Yaseen M. Arabi, Shehnoor Azhar, Lindsey R. Baden, Arthur W. Baker, Leila Belkhir, Thomas Benfield, Marvin A. H. Berrevoets, Cheng-Pin Chen, Tsung-Chia Chen, Shu-Hsing Cheng, Chien-Yu Cheng, Wei-Sheng Chung, Yehuda Z. Cohen, Lisa N. Cowan, Olav Dalgard, Fernando F. de Almeida e Val, Marcus V. G. de Lacerda, Gisely C. de Melo, Lennie Derde, Vincent Dubee, Anissa Elfakir, Anthony C. Gordon, Carmen M. Hernandez-Cardenas, Thomas Hills, Andy I. M. Hoepelman, Yi-Wen Huang, Bruno Igau, Ronghua Jin, Felipe Jurado-Camacho, Khalid S. Khan, Peter G. Kremsner, Benno Kreuels, Cheng-Yu Kuo, Thuy Le, Yi-Chun Lin, Wu-Pu Lin, Tse-Hung Lin, Magnus Nakrem Lyngbakken, Colin McArthur, Bryan J. McVerry, Patricia Meza-Meneses, Wuelton M. Monteiro, Susan C. Morpeth, Ahmad Mourad, Mark J. Mulligan, Srinivas Murthy, Susanna Naggie, Shanti Narayanasamy, Alistair Nichol, Lewis A. Novack, Sean M. O’Brien, Nwora Lance Okeke, Léna Perez, Rogelio Perez-Padilla, Laurent Perrin, Arantxa Remigio-Luna, Norma E. Rivera-Martinez, Frank W. Rockhold, Sebastian Rodriguez-Llamazares, Robert Rolfe, Rossana Rosa, Helge Røsjø, Vanderson S. Sampaio, Todd B. Seto, Muhammad Shahzad, Shaimaa Soliman, Jason E. Stout, Ireri Thirion-Romero, Andrea B. Troxel, Ting-Yu Tseng, Nicholas A. Turner, Robert J. Ulrich, Stephen R. Walsh, Steve A. Webb, Jesper M. Weehuizen, Maria Velinova, Hon-Lai Wong, Rebekah Wrenn, Fernando G. Zampieri, Wu Zhong, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/eaaad84f79e74e2bbfb5c0c8a4146fc5
Autor:
Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud, Janneke van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, Javed Akram, Ravi K. Amaravadi, Derek C. Angus, Yaseen M. Arabi, Shehnoor Azhar, Lindsey R. Baden, Arthur W. Baker, Leila Belkhir, Thomas Benfield, Marvin A. H. Berrevoets, Cheng-Pin Chen, Tsung-Chia Chen, Shu-Hsing Cheng, Chien-Yu Cheng, Wei-Sheng Chung, Yehuda Z. Cohen, Lisa N. Cowan, Olav Dalgard, Fernando F. de Almeida e Val, Marcus V. G. de Lacerda, Gisely C. de Melo, Lennie Derde, Vincent Dubee, Anissa Elfakir, Anthony C. Gordon, Carmen M. Hernandez-Cardenas, Thomas Hills, Andy I. M. Hoepelman, Yi-Wen Huang, Bruno Igau, Ronghua Jin, Felipe Jurado-Camacho, Khalid S. Khan, Peter G. Kremsner, Benno Kreuels, Cheng-Yu Kuo, Thuy Le, Yi-Chun Lin, Wu-Pu Lin, Tse-Hung Lin, Magnus Nakrem Lyngbakken, Colin McArthur, Bryan J. McVerry, Patricia Meza-Meneses, Wuelton M. Monteiro, Susan C. Morpeth, Ahmad Mourad, Mark J. Mulligan, Srinivas Murthy, Susanna Naggie, Shanti Narayanasamy, Alistair Nichol, Lewis A. Novack, Sean M. O’Brien, Nwora Lance Okeke, Léna Perez, Rogelio Perez-Padilla, Laurent Perrin, Arantxa Remigio-Luna, Norma E. Rivera-Martinez, Frank W. Rockhold, Sebastian Rodriguez-Llamazares, Robert Rolfe, Rossana Rosa, Helge Røsjø, Vanderson S. Sampaio, Todd B. Seto, Muhammad Shahzad, Shaimaa Soliman, Jason E. Stout, Ireri Thirion-Romero, Andrea B. Troxel, Ting-Yu Tseng, Nicholas A. Turner, Robert J. Ulrich, Stephen R. Walsh, Steve A. Webb, Jesper M. Weehuizen, Maria Velinova, Hon-Lai Wong, Rebekah Wrenn, Fernando G. Zampieri, Wu Zhong, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydro
Externí odkaz:
https://doaj.org/article/d742d7263e7f4393b9fbfd3d3114ad61
Autor:
Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud, Janneke van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, Javed Akram, Ravi K. Amaravadi, Derek C. Angus, Yaseen M. Arabi, Shehnoor Azhar, Lindsey R. Baden, Arthur W. Baker, Leila Belkhir, Thomas Benfield, Marvin A. H. Berrevoets, Cheng-Pin Chen, Tsung-Chia Chen, Shu-Hsing Cheng, Chien-Yu Cheng, Wei-Sheng Chung, Yehuda Z. Cohen, Lisa N. Cowan, Olav Dalgard, Fernando F. de Almeida e Val, Marcus V. G. de Lacerda, Gisely C. de Melo, Lennie Derde, Vincent Dubee, Anissa Elfakir, Anthony C. Gordon, Carmen M. Hernandez-Cardenas, Thomas Hills, Andy I. M. Hoepelman, Yi-Wen Huang, Bruno Igau, Ronghua Jin, Felipe Jurado-Camacho, Khalid S. Khan, Peter G. Kremsner, Benno Kreuels, Cheng-Yu Kuo, Thuy Le, Yi-Chun Lin, Wu-Pu Lin, Tse-Hung Lin, Magnus Nakrem Lyngbakken, Colin McArthur, Bryan J. McVerry, Patricia Meza-Meneses, Wuelton M. Monteiro, Susan C. Morpeth, Ahmad Mourad, Mark J. Mulligan, Srinivas Murthy, Susanna Naggie, Shanti Narayanasamy, Alistair Nichol, Lewis A. Novack, Sean M. O’Brien, Nwora Lance Okeke, Léna Perez, Rogelio Perez-Padilla, Laurent Perrin, Arantxa Remigio-Luna, Norma E. Rivera-Martinez, Frank W. Rockhold, Sebastian Rodriguez-Llamazares, Robert Rolfe, Rossana Rosa, Helge Røsjø, Vanderson S. Sampaio, Todd B. Seto, Muhammad Shahzad, Shaimaa Soliman, Jason E. Stout, Ireri Thirion-Romero, Andrea B. Troxel, Ting-Yu Tseng, Nicholas A. Turner, Robert J. Ulrich, Stephen R. Walsh, Steve A. Webb, Jesper M. Weehuizen, Maria Velinova, Hon-Lai Wong, Rebekah Wrenn, Fernando G. Zampieri, Wu Zhong, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/d0947ff1565449f5b1b558ecad2d8d9d
Autor:
Anca Boldea, Stefanie Schier-Mumzhiu, Anne Bellon, Ahad Sabet, Sven D. Koch, Celine Schelcher, Maria Velinova, Roumen Nakov, Sreekanth Gattu, Daniel Dickerson, Andrej Skerjanec, Charles Tomek, Steven Schussler, Jessie Wang, Terry O'Reilly, Ly Ngo, Gordon P. Otto, Miryana Dobreva
Publikováno v:
British Journal of Clinical Pharmacology
Aims Recombinant PEGylated human granulocyte colony-stimulating factor (pegfilgrastim) is indicated for the reduction of chemotherapy-induced neutropenia and prevention of febrile neutropenia. Biosimilar pegfilgrastim is expected to reduce the financ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1456530735daa455f7afd224ba47188f
http://europepmc.org/articles/PMC7256126
http://europepmc.org/articles/PMC7256126
Autor:
Oliver von Richter, Thomas Koernicke, Lena Lemke, Johann Poetzl, Julia Jauch-Lembach, Maria Velinova, Ellen Schuck, Halimuniyazi Haliduola, Andrej Skerjanec, Rainard Fuhr
Publikováno v:
Expert Opinion on Biological Therapy. 19:1075-1083
Background: To compare the pharmacokinetics of Sandoz biosimilar adalimumab (GP2017) with reference adalimumab (Humira) in healthy volunteers (PK similarity study) and to compare the pharmacokineti...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07a4b19ed85fb54adcd7ab704440769
https://doi.org/10.1080/14712598.2019.1571580
https://doi.org/10.1080/14712598.2019.1571580
Autor:
Steven N. Goodman, Norma E. Rivera-Martinez, Magnus Nakrem Lyngbakken, David Moher, John P. A. Ioannidis, Frank W. Rockhold, Todd B. Seto, Helge Røsjø, Vincent Dubée, Ahmad Mourad, Andrea B. Troxel, Carmen M. Hernández-Cárdenas, Vanderson de Souza Sampaio, Thuy Le, Andy I. M. Hoepelman, Fernando Val, Sean M. O'Brien, Ting Yu Tseng, Leila Belkhir, Susanna Naggie, Patricia Meza-Meneses, Marvin A.H. Berrevoets, Javed Akram, Alistair Nichol, Léna Perez, Rebekah Wrenn, Susan C. Morpeth, Laurent Perrin, Felipe Jurado-Camacho, Lindsey R. Baden, Shehnoor Azhar, Bryan J. McVerry, Cheng-Yu Kuo, Arantxa Remigio-Luna, Thomas Hills, Cathrine Axfors, Ireri Thirion-Romero, Steve Webb, Wuelton Marcelo Monteiro, Jason E. Stout, Jesper M. Weehuizen, Peter G. Kremsner, Shanti Narayanasamy, Derek C. Angus, Yehuda Z. Cohen, Shu Hsing Cheng, Gisely Cardoso de Melo, Rossana Rosa, Nwora Lance Okeke, Stephen R. Walsh, Srinivas Murthy, Anissa Elfakir, Mark J. Mulligan, Olav Dalgard, Cheng-Pin Chen, Tse Hung Lin, Fernando G. Zampieri, Khalid S. Khan, Yi-Wen Huang, Anthony C. Gordon, Yaseen M. Arabi, Wu Zhong, Hon Lai Wong, Wei Sheng Chung, Bruno Igau, Andreas M. Schmitt, Maria Velinova, Robert J. Ulrich, Nicholas A Turner, Wu Pu Lin, Janneke van’t Hooft, Shaimaa Soliman, Lennie P. G. Derde, Colin McArthur, Arthur W. Baker, Benno Kreuels, Ravi K. Amaravadi, Ronghua Jin, Benjamin S. Abella, Sherief Abd-Elsalam, Thomas Benfield, Lewis A. Novack, Lars G. Hemkens, Ehab F. Abdo, Perrine Janiaud, Sebastian Rodriguez-Llamazares, Chien Yu Cheng, Muhammad Shahzad, Robert Rolfe, Tsung Chia Chen, Yi-Chun Lin, Rogelio Perez-Padilla, Marcus V. G. Lacerda, Lisa N. Cowan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Nature Communications
Nature Communications
Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd12e44c7dfe0fbf267480cac84e1c96
http://hdl.handle.net/10044/1/89425
http://hdl.handle.net/10044/1/89425
Autor:
Akinori Arimura, Kyoko Miyamoto, Maria Velinova, Marieke van den Dobbelsteen, Katsuhiro Mihara, Robert M. Miller, Masaaki Sawa
Publikováno v:
Cancer Research. 82:CT137-CT137
Background: Covalent Bruton’s tyrosine kinase (BTK) inhibitors such as ibrutinib are approved for treating patients with B-cell malignancies, but their long-term efficacy is limited due to their toxicity (i.e., on-target and off-target inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b507bbe93fa53c0f541f0fe7f69a0b82
https://doi.org/10.1158/1538-7445.am2022-ct137
https://doi.org/10.1158/1538-7445.am2022-ct137
Autor:
Angela Sinn, Lars Blumenstein, Sebastien Lorenzo, Monika Gajewska, Martin Mueller-Zsigmondy, Tycho Heimbach, Maria Velinova, Alexandros Kourentas
Publikováno v:
The AAPS Journal. 22
A physiologically based pharmacokinetic (PBPK) human model for alpelisib, an oral α-specific class I phosphatidylinositol-3-kinase (PI3K) inhibitor, was established to simulate oral absorption and plasma pharmacokinetics of healthy subjects to allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013d4d8ad6f5b8a300187c5718423181
https://doi.org/10.1208/s12248-020-00511-7
https://doi.org/10.1208/s12248-020-00511-7
Autor:
Thomas Hills, Cathrine Axfors, Yehuda Z. Cohen, Nwora Lance Okeke, Fernando G. Zampieri, Lindsey R. Baden, Ting-Yu Tseng, Derek C. Angus, Vanderson de Souza Sampaio, Thuy Le, Bruno Igau, Fernando Almeida Val, Shanti Narayanasamy, Tsung-Chia Chen, Shaimaa Soliman, Srinivas Murthy, Nicholas A Turner, Lennie P. G. Derde, Sean M. O'Brien, Cheng-Pin Chen, Todd B. Seto, Benjamin S. Abella, Ireri Thirion-Romero, Stephen R. Walsh, Muhammad Shehzad, Wu Zhong, Yaseen M. Arabi, Sherief Abd-Elsalam, Anissa Elfakir, Javed Akram, Léna Perez, Mark J. Mulligan, Wei-Sheng Chung, John P. A. Ioannidis, Khalid S. Khan, Yi-Wen Huang, Felipe Jurado-Camacho, Thomas Benfield, Wuelton Marcelo Monteiro, Jason E. Stout, Anthony C. Gordon, Bryan J. McVerry, Lars G. Hemkens, Robert J. Ulrich, Colin McArthur, Sebastian Rodriguez-Llamazares, Hon-Lai Wong, Norma E. Rivera-Martinez, Leila Belkhir, Magnus Nakrem Lyngbakken, Andy I. M. Hoepelman, Ehab F. Abdo, David Moher, Maria Velinova, Benno Kreuels, Arthur W. Baker, Ravi K. Amaravadi, Ahmad Mourad, Ronghua Jin, Perrine Janiaud, Shehnoor Azhar, Marvin A.H. Berrevoets, Chien-Yu Cheng, Arantxa Remigio-Luna, Shu-Hsing Cheng, Lewis A. Novack, Steve Webb, Steven N. Goodman, Helge Røsjø, Tse-Hung Lin, Vincent Dubée, Andrea B. Troxel, Frank W. Rockhold, Rossana Rosa, Peter G. Kremsner, Rebekah Wrenn, Susan C. Morpeth, Laurent Perrin, Andreas M. Schmitt, Robert Rolfe, Alistair Nichol, Carmen M. Hernández-Cárdenas, Janneke van 't Hooft, Olav Dalgard, Susanna Naggie, Yi-Chun Lin, Jesper M. Weehuizen, Gisely Cardoso de Melo, Wu-Pu Lin, Patricia Meza-Meneses, Cheng-Yu Kuo, Lisa N. Cowan, Rogelio Perez-Padilla, Marcus V. G. Lacerda
BackgroundSubstantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aimed to estimate the effects of hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::003f712b1e8ba2d7714ca7dc999d049c
https://doi.org/10.1101/2020.09.16.20194571
https://doi.org/10.1101/2020.09.16.20194571