Epidermal Growth Factor Receptor Inhibition Reverses Cellular and Transcriptomic Alterations Induced by Hypoxia in the Neonatal Piglet Brain

Autor: Panagiotis Kratimenos, Evan Z. Goldstein, Ioannis Koutroulis, Susan Knoblach, Beata Jablonska, Payal Banerjee, Shadi N. Malaeb, Surajit Bhattacharya, M. Isabel Almira-Suarez, Vittorio Gallo, Maria Delivoria-Papadopoulos

Publikováno v: iScience, Vol 23, Iss 12, Pp 101766- (2020)

Summary: Acute hypoxia (HX) causes extensive cellular damage in the developing human cerebral cortex. We found increased expression of activated-EGFR in affected cortical areas of neonates with HX and investigated its functional role in the piglet, w

Externí odkaz: https://doaj.org/article/47be4abbcf6445059095a33d92ed3cc3

Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model

Autor: Dimitrios Angelis, Maria Delivoria-Papadopoulos

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

Background. Protein tyrosine phosphatases (PTPs) in conjunction with protein tyrosine kinases (PTKs) regulate cellular processes by posttranslational modifications of signal transduction proteins. PTP nonreceptor type 1B (PTP-1B) is an enzyme of the

Externí odkaz: https://doaj.org/article/1796d3cc58ae4becb5926925a3305433

Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury

Autor: Panagiotis Kratimenos, Abhya Vij, Robinson Vidva, Ioannis Koutroulis, Maria Delivoria-Papadopoulos, Vittorio Gallo, Aaron Sathyanesan

Publikováno v: Journal of neurodevelopmental disorders. 14(1)

Background Neonatal hypoxic brain injury is a major cause of intellectual and developmental disability. Hypoxia causes neuronal dysfunction and death in the developing cerebral cortex due to excitotoxic Ca2+-influx. In the translational piglet model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2041636dd7efaeca16e32ede3343dfd0
https://pubmed.ncbi.nlm.nih.gov/35351004

Biomechanical Responses of Neonatal Brachial Plexus to Mechanical Stretch

Autor: Shania Shaji, Sriram Balasubramanian, Anita Singh, Maria Delivoria-Papadopoulos

Publikováno v: Journal of Brachial Plexus and Peripheral Nerve Injury
Journal of Brachial Plexus and Peripheral Nerve Injury, Vol 13, Iss 01, Pp e8-e14 (2018)

This study investigated the biomechanical responses of neonatal piglet brachial plexus (BP) segments—root/trunk, chord, and nerve at two different rates, 0.01 mm/second (quasistatic) and 10 mm/second (dynamic)—and compared their response to anoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8eb01c60421711564afff06da936948
https://doi.org/10.1055/s-0038-1669405

Effect of Concurrent Src Kinase Inhibition with Short-Duration Hypothermia on Ca2+/Calmodulin Kinase IV Activity and Neuropathology after Hypoxia-Ischemia in the Newborn Swine Brain

Autor: Amit Jain, Ioannis Koutroulis, Shadi N. Malaeb, Panagiotis Kratimenos, Maria Delivoria-Papadopoulos

Publikováno v: Neonatology. 113:37-43

Background: Hypoxia-ischemia (HI) results in increased activation of Ca2+/calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury in the newborn. Hypothesis: Inhibition of Src kinase concurrent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130de4b9be23f75dd6c4ce6abce27e74
https://doi.org/10.1159/000480067