Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Maria Ölwegård"'
Autor:
Adam M Corrigan, Johan Karlsson, Jan Wildenhain, Laurent Knerr, Maria Ölwegård-Halvarsson, Maria Karlsson, Svenja Lünse, Yinhai Wang
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220627 (2019)
This work presents a MATLAB-based software package for high-throughput microscopy image analysis development, making such development more accessible for a large user community. The toolbox provides a GUI and a number of analysis workflows, and can s
Externí odkaz:
https://doaj.org/article/77d0eb1ec421405eae77e972d835693b
Autor:
Nicholas D. Oakes, Ann Kjellstedt, Gun-Britt Forsberg, Tony Clementz, Germán Camejo, Stuart M. Furler, Edward W. Kraegen, Maria Ölwegård-Halvarsson, Arthur B. Jenkins, Bengt Ljung
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 6, Pp 1155-1169 (1999)
We describe a method for assessing tissue-specific plasma free fatty acid (FFA) utilization in vivo using a non-β-oxidizable FFA analog, [9,10-3H]-(R)-2-bromopalmitate (3H-R-BrP). Ideally 3H-R-BrP would be transported in plasma, taken up by tissues
Externí odkaz:
https://doaj.org/article/cbbe7cd150e6498d9ead78d4f8fdacf5
Autor:
Punit P. Seth, Johan Broddefalk, Patrik U. Andersson, Johan Meuller, Michael E. Østergaard, Thazha P. Prakash, Linda Sundström, Leonardo De Maria, Wuxia Fu, Ahlke Hayen, David Janzén, Carina Ämmälä, Eric Valeur, Laurent Knerr, Maria Ölwegård-Halvarsson, Richard G. Lee, Shalini Andersson, William J. Drury, Elaine Pirie, Mehran Nikan, Rasmus Jansson-Löfmark
Publikováno v:
Journal of the American Chemical Society. 143:3416-3429
The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and hampers the widespread application of this powerful class of therapeutic agents. In that regard, pancreatic beta cells are a particularly attractive but challengi
Publikováno v:
Chemical Society reviews. 50(3)
Peptides can offer the versatility needed for a successful oncology drug discovery approach. Peptide-drug conjugates (PDCs) are an emerging targeted therapeutic that present increased tumour penetration and selectivity. Despite these advantages, ther
Akademický článek
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Autor:
Kristina Berggren, Nils-Olov Hermansson, Petra Johannesson, Annika Wellner, Jonas Brånalt, Kristina Nilsson, Henrik Gradén, Maria Ölwegård-Halvarsson, Ola Fjellström, Bengt Ohlsson, Terese Andersson, Öjvind Davidsson, Linda Gustafsson, Christian Tyrchan, Yantao Chen, Frank Jansen, Eric Wellner
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(4)
GPR81 is a novel drug target that is implicated in the control of glucose and lipid metabolism. The lack of potent GPR81 modulators suitable for in vivo studies has limited the pharmacological characterization of this lactate sensing receptor. We per
Autor:
C. Wern, Y. Örtengren, M. Strimfors, Ulf Eriksson, S. Nielsen, A.-C. Egnell, Ulf Bredberg, Joakim Bergman, T. Skjaeret, S. Pehrsson, Jonas Brånalt, K.-J. Hoffman, K. Abrahamsson, Ingemar Nilsson, Maria Ölwegård-Halvarsson, Polla Magnus, David Gustafsson, P. Andersson
Publikováno v:
MedChemComm. 7:272-281
A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions. This work resulted in the identification of the highly potent thrombin inhibitor compou
Publikováno v:
Drug discovery today. 22(6)
Regenerative approaches are promising avenues to effectively cure diseases rather than merely treating symptoms, but are associated with concerns around proliferation in other organs. Given that targeted delivery holds the promise of delivering a dru
Autor:
Thomas Elebring, Jan-Erik Sjöström, Beritte Christenson, Bo Lamm, Ann-Charlotte Klintenberg, Thomas C Kühler, Roberto Giuseppe Paolo Gatti, Jonas Fägerhag, Maria Ölwegård-Halvarsson, Vladimir Shcherbuchin, Marianne Swanson
Publikováno v:
Journal of Medicinal Chemistry. 45:4282-4299
2-[[(2-Pyridyl)methyl]thio]-1H-benzimidazoles (2, sulfides) exhibit antibacterial properties that are selective for Helicobacter spp., but they also have an inherent susceptibility to metabolic oxidation to furnish 2-[[(2-pyridyl)methyl]sulfinyl]-1H-
Autor:
Gun-Britt Forsberg, Maria Ölwegård-Halvarsson, Edward W. Kraegen, Germán Camejo, A. B. Jenkins, Stuart M. Furler, Bengt Ljung, Tony Clementz, Nicholas D. Oakes, Ann Kjellstedt
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 6, Pp 1155-1169 (1999)
We describe a method for assessing tissue-specific plasma free fatty acid (FFA) utilization in vivo using a non-β-oxidizable FFA analog, [9,10-3H]-(R)-2-bromopalmitate (3H-R-BrP). Ideally 3H-R-BrP would be transported in plasma, taken up by tissues