Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maria L. Watson"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25975 (2011)
BACKGROUND:Sustained exposure of pancreatic β cells to an increase in saturated fatty acids induces pleiotropic effects on β-cell function, including a reduction in stimulus-induced insulin secretion. The objective of this study was to investigate
Externí odkaz:
https://doaj.org/article/e5abfa5cd43344deaad03875a77a287d
Autor:
Alexander Gray, Olivier Drouin, André Marette, Maria L. Watson, Louise Lantier, Harinder S. Hundal, Charlotte J. Green, Benoit Viollet, Sophie Turban, Fiona A. Ross, Clare Stretton, D. Grahame Hardie
Publikováno v:
The Journal of Biological Chemistry
Background: The role of AMPK and PKCs as effectors of metformin action on glucose uptake (GU) in skeletal muscle cells was investigated. Results: Genetic loss/silencing of AMPK led to only a small repression in metformin-stimulated GU. Novel/conventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b510e5c7bbf170096ee0a25d6b609bd
http://europepmc.org/articles/PMC3370192
http://europepmc.org/articles/PMC3370192
Publikováno v:
The Biochemical journal. 417(3)
Saturated fatty acids, such as palmitate, promote accumulation of ceramide, which impairs activation and signalling of PKB (protein kinase B; also known as Akt) to important end points such as glucose transport. SPT (serine palmitoyl transferase) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d730b7cbfe67e0b17c7d2589f91fa4
https://pubmed.ncbi.nlm.nih.gov/18922131
https://pubmed.ncbi.nlm.nih.gov/18922131
Publikováno v:
The Biochemical journal. 399(3)
An increase in circulating levels of specific NEFAs (non-esterified fatty acids) has been implicated in the pathogenesis of insulin resistance and impaired glucose disposal in skeletal muscle. In particular, elevation of SFAs (saturated fatty acids),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aeef916d84231f9cb435a81e26f8fc
https://pubmed.ncbi.nlm.nih.gov/16822230
https://pubmed.ncbi.nlm.nih.gov/16822230
Publikováno v:
Biochemical Journal; 2009, Vol. 417 Issue 3, p791-801, 11p