JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

Autor: Alexey Sarapultsev, Evgenii Gusev, Maria Komelkova, Irina Utepova, Shanshan Luo, Desheng Hu

Publikováno v: Molecular Biomedicine, Vol 4, Iss 1, Pp 1-30 (2023)

Abstract The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathw

Externí odkaz: https://doaj.org/article/5b785b0d7fa24456af51df9e6f8927c9

Somatic and psychological distress among Russian university students during the COVID-19 pandemic

Autor: Alena Zolotareva, Svetlana Belousova, Irina Danilova, Vadim Tseilikman, Maxim Lapshin, Lilia Sarapultseva, Svetlana Makhniova, Igor Kritsky, Roman Ibragimov, Desheng Hu, Maria Komelkova

Publikováno v: International Journal of Psychiatry in Medicine

Objective Previous studies highlighted a high prevalence of mental health issues among students during the COVID-19 pandemic, but there is no evidence from Russia. This study was aimed to examine the prevalence of somatic and psychological distress a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ebf1cfb0fc76a19073f61fb04ae11c
https://elar.rsvpu.ru/handle/123456789/42466

Low glucocorticoids in stress-related disorders: the role of inflammation

Autor: Eliyahu Dremencov, Vadim Tseilikman, Maria Komelkova, Olga B. Tseilikman, Alexey Sarapultsev, Petr Sarapultsev

Publikováno v: Stress. 23:651-661

There is evidence that plasma cortisol concentration can be either increased or decreased in patients with depression and related anxiety and stress-related disorders; the exact pathophysiological mechanisms of this state are not almost clear. Severa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56074f883ef78362a9276777d6d2352
https://doi.org/10.1080/10253890.2020.1766020

A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland

Autor: Vadim Tseilikman, Maria Komelkova, Marina V. Kondashevskaya, Eugenia Manukhina, H. Fred Downey, Valerii Chereshnev, Margarita Chereshneva, Pavel Platkovskii, Anna Goryacheva, Anton Pashkov, Julia Fedotova, Olga Tseilikman, Natalya Maltseva, Olga Cherkasova, Charlotte Steenblock, Stefan R. Bornstein, Barbara Ettrich, George P. Chrousos, Enrico Ullmann

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13235
International Journal of Molecular Sciences, Vol 22, Iss 13235, p 13235 (2021)

Background: Rats exposed to chronic predator scent stress mimic the phenotype of complex post-traumatic stress disorder (PTSD) in humans, including altered adrenal morphology and function. High- and low-anxiety phenotypes have been described in rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8bbee69a738f9709896d537f19c0b3
https://www.zora.uzh.ch/id/eprint/214900/

Hexobarbital Sleep Test for Predicting the Susceptibility or Resistance to Experimental Posttraumatic Stress Disorder

Autor: Olga B. Tseilikman, H. Fred Downey, David Tseilikman, Alexey Sarapultsev, Maria Komelkova, Petr Sarapultsev, Olga P. Cherkasova, Stanislav Fedorov, Eugenia B. Manukhina, Viacheslav Kotomtsev, Vadim Tseilikman, Pavel Platkovskiy

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5900, p 5900 (2020)

Hexobarbital sleep test (HST) was performed in male Wistar rats (hexobarbital 60 mg/kg, i.p.) 30 days prior to stress exposure. Based on the duration of hexobarbital-induced sleep, rats were divided into two groups, animals with high intensity (fast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb6cdf4cb9ae441b605ec18c7d88d35
http://europepmc.org/articles/PMC7460591