Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Maria, Hatzoglou"'
Autor:
Anna M. Smirnova, Vladislava Hronová, Mahabub Pasha Mohammad, Anna Herrmannová, Stanislava Gunišová, Denisa Petráčková, Petr Halada, Štěpán Coufal, Michał Świrski, Justin Rendleman, Kristína Jendruchová, Maria Hatzoglou, Petra Beznosková, Christine Vogel, Leoš Shivaya Valášek
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113976- (2024)
Summary: Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the integrated stress response, leading cells toward adaptation or death. ATF4’s induction under stress was thought to be due to delayed translation reinitia
Externí odkaz:
https://doaj.org/article/0f04c695bf164ff7a96d9c1f5bcc5a53
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
Chien-Wen Chen, Bo-Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya Bederman, Peter Arvan, Clayton E. Mathews, Ivan C. Gerling, Klaus H. Kaestner, Boaz Tirosh, Feyza Engin, Maria Hatzoglou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogene
Externí odkaz:
https://doaj.org/article/adc88863189241eabee325b0cf1b9532
Autor:
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting i
Externí odkaz:
https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df9
Autor:
Tong Zhao, Tihua Zheng, Huining Yu, Bo Hua Hu, Bing Hu, Peng Ma, Ying Yang, Naidi Yang, Juan Hu, Tongtao Cao, Gang Chen, Bin Yan, Melina Peshoff, Maria Hatzoglou, Ruishuang Geng, Bo Li, Qing Yin Zheng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Macroautophagy/autophagy is a highly conserved self-digestion pathway that plays an important role in cytoprotection under stress conditions. Autophagy is involved in hepatotoxicity induced by acetaminophen (APAP) in experimental animals and
Externí odkaz:
https://doaj.org/article/5b34cabca9e94098951e16b9308b23ba
Autor:
Theodore L. Mathuram, Danyelle M. Townsend, Vincent J. Lynch, Ilya Bederman, Zhi-Wei Ye, Jie Zhang, Wade J. Sigurdson, Erin Prendergast, Raul Jobava, Jonathan P. Ferruzza, Mary R. D’Angelo, Maria Hatzoglou, Yaron Perry, Anna Blumental-Perry
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Mitochondrial malfunction is a hallmark of many diseases, including neurodegenerative disorders, cardiovascular and lung diseases, and cancers. We previously found that alveolar progenitor cells, which are more resistant to cigarette smoke-induced in
Externí odkaz:
https://doaj.org/article/f5dff9159b59448badb5f7f4173eea60
Autor:
Michael Jewer, Laura Lee, Matthew Leibovitch, Guihua Zhang, Jiahui Liu, Scott D. Findlay, Krista M. Vincent, Kristofferson Tandoc, Dylan Dieters-Castator, Daniela F. Quail, Indrani Dutta, Mackenzie Coatham, Zhihua Xu, Aakshi Puri, Bo-Jhih Guan, Maria Hatzoglou, Andrea Brumwell, James Uniacke, Christos Patsis, Antonis Koromilas, Julia Schueler, Gabrielle M. Siegers, Ivan Topisirovic, Lynne-Marie Postovit
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progressi
Externí odkaz:
https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90
Autor:
Mohammed R Alzahrani, Bo-Jhih Guan, Leah L Zagore, Jing Wu, Chien-Wen Chen, Donny D Licatalosi, Kristian E Baker, Maria Hatzoglou
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0271695 (2022)
Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The UPR reprograms gene expression to promote adaptation to chronic ER stress
Externí odkaz:
https://doaj.org/article/d366124372274fe29bdaafd94e7ed8ac
Autor:
David Danielpour, Zhaofeng Gao, Patrick M. Zmina, Eswar Shankar, Benjamin C. Shultes, Raul Jobava, Scott M. Welford, Maria Hatzoglou
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract The imidazolium compound YM155, first discovered as a potent inhibitor of Survivin, effectively kills many carcinomas in preclinical models. However, the upstream signaling mechanism triggered by YM155 remains unclear. Here we studied early
Externí odkaz:
https://doaj.org/article/413a98d689b543009470d4c60ab64d4b
Autor:
Amy H. Attaway, Annette Bellar, Saurabh Mishra, Manikandan Karthikeyan, Jinendiran Sekar, Nicole Welch, Ryan Musich, Shashi Shekhar Singh, Avinash Kumar, Aishwarya Menon, Jasmine King, Ramon Langen, Justine Webster, Rachel G. Scheraga, Kristy Rochon, Jason Mears, Sathyamangla V. Naga Prasad, Maria Hatzoglou, Abhishek A. Chakraborty, Srinivasan Dasarathy
Publikováno v:
The Journal of Physiology, 601(3), 567-606. Wiley-Blackwell
KEY POINTS: Sarcopenia or skeletal muscle loss is one of the most frequent complications that contributes to mortality and morbidity in patients with chronic obstructive pulmonary disease (COPD). Unlike chronic hypoxia, prolonged intermittent hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed0bb6a32c36206eeedb85ac4dfdd00
https://doi.org/10.1113/JP283700
https://doi.org/10.1113/JP283700