Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria, Groves"'
Autor:
Darren J. Schofield, Jennifer Percival-Alwyn, Mateusz Rytelewski, John Hood, Raymond Rothstein, Leslie Wetzel, Kelly McGlinchey, Grace Adjei, Amanda Watkins, LeeAnn Machiesky, Weimin Chen, John Andrews, Maria Groves, Michelle Morrow, Ross A. Stewart, Andrew Leinster, Robert W. Wilkinson, Scott A. Hammond, Nadia Luheshi, Claire Dobson, Michael Oberst
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Externí odkaz:
https://doaj.org/article/5b7084f79f5a4c06ad3eff39bdaa115c
Autor:
Katerina Koether, Valérie Besnard, Hilary Sandig, Alan Carruthers, Elena Miranda, Sabine Grootenboer-Mignot, Camille Taillé, Sylvie Chevret, Dominique Valeyre, Hilario Nunes, Dominique Israel-Biet, Wei Keat Lim, Vincent Cottin, Dominic Corkill, Claire Dobson, Maria Groves, Franco Ferraro, Edouard Guenzi, Ling Huang, Michal Sulikowski, Arnaud Mailleux, Lynne Anne Murray, Thomas Mustelin, Ian Strickland, Matthew A. Sleeman, Bruno Crestani
Publikováno v:
European Respiratory Journal. 61:2102381
Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients with IPF have an altered B-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95358d2839982a50572e71334e6b82e4
https://doi.org/10.1183/13993003.02381-2021
https://doi.org/10.1183/13993003.02381-2021
Autor:
Timothy O, Cox, Erik C, Gunther, A Harrison, Brody, Marius T, Chiasseu, Austin, Stoner, Levi M, Smith, Laura T, Haas, Jayne, Hammersley, Gareth, Rees, Bhupinder, Dosanjh, Maria, Groves, Matthew, Gardener, Claire, Dobson, Tristan, Vaughan, Iain, Chessell, Andrew, Billinton, Stephen M, Strittmatter
Publikováno v:
Annals of Clinical and Translational Neurology
Objective Amyloid‐beta oligomers (Aßo) trigger the development of Alzheimer's disease (AD) pathophysiology. Cellular prion protein (PrPC) initiates synaptic damage as a high affinity receptor for Aßo. Here, we evaluated the preclinical therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d36f7f5c180265d45d862a4329636ad4
https://pubmed.ncbi.nlm.nih.gov/30911579
https://pubmed.ncbi.nlm.nih.gov/30911579
Publikováno v:
Journal of Alzheimer's Disease
Utilizing decision making biomarkers in drug development requires thorough assay validation. Special considerations need to be taken into account when monitoring biomarkers using immunoassays in the presence of therapeutic antibodies. We have develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abcea38ef76512dec08ad65b72b08fa
https://doi.org/10.3233/jad-142988
https://doi.org/10.3233/jad-142988
Autor:
Elizabeth England, Trevor Wilkinson, Sarah Welsted, Jayesh B. Majithiya, Claire Dobson, Dominic J. Corkill, E. Suzanne Cohen, Natalie J. Tigue, Tristan J. Vaughan, Matthew J. Robinson, Kevin Minton, Jennifer L. Percival-Alwyn, Benjamin Kemp, Maria Groves, Laura Rapley, Nicola H.E. Davis, Grant R McCarthy
Publikováno v:
mAbs
Immunization of mice or rats with a "non-self" protein is a commonly used method to obtain monoclonal antibodies, and relies on the immune system's ability to recognize the immunogen as foreign. Immunization of an antigen with 100% identity to the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabe7508e6d14fe457a15daa6ec0ec7d
https://doi.org/10.4161/19420862.2014.985489
https://doi.org/10.4161/19420862.2014.985489
Autor:
Phil Newton, Michael S. Perkinton, Maria Groves, Tristan J. Vaughan, Anna Bogstedt, Iain P. Chessell, Amanda Dudley, Fraser Welsh, Chris Lloyd, Rajesh Narwal, Keith Tan, Mary McFarlane, Andy Billinton, Susanna Eketjäll
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620691fdfa6c401ece60ddc6f0d907de
https://doi.org/10.1016/j.jalz.2017.06.141
https://doi.org/10.1016/j.jalz.2017.06.141
Autor:
Tomas Ondrejcak, Andy Billinton, Dominic M. Walsh, Maria Groves, Michael S. Perkinton, Tiernan T. O'Malley, Iain P. Chessell, Michael J. Rowan, Amanda Dudley
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bedc06a7ecca4fdd9ffcdf3d7c209965
https://doi.org/10.1016/j.jalz.2017.06.1849
https://doi.org/10.1016/j.jalz.2017.06.1849
Autor:
Thor Ostenfeld, Richard Turner, Eva Lindqvist, Amanda Dudley, Iain P. Chessell, Michael Pomfret, Manasa Tatipalli, Rajesh Narwal, Nancy Y. Lee, Maria Groves, Andy Billinton, Keith Tan, Zulma Santisteban Valencia, Tharani Chessell
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17f14d1d931d7782520701072c2690af
https://doi.org/10.1016/j.jalz.2017.07.193
https://doi.org/10.1016/j.jalz.2017.07.193
Publikováno v:
Methods. 36:61-68
Guided selection is a method of producing a human version of a rodent or any other non-human antibody. The process is a serial transition from rodent to human via rodent-human chimaerics, through to a panel of human antibodies with similar characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f555e4846da7e1184c11d15b46ca4bdb
https://doi.org/10.1016/j.ymeth.2005.01.006
https://doi.org/10.1016/j.ymeth.2005.01.006
Autor:
Lutz Jermutus, Hung Lee, Claudia Sheedy, Shenghua Li, C. Roger MacKenzie, Maria Groves, J. Christopher Hall, Kerrm Y. Yau, Jamshid Tanha
Publikováno v:
Journal of Immunological Methods. 281:161-175
Picloram-specific variable fragments (V(HH)s) of heavy chain antibodies (HCAbs) were selected from a nai;ve-llama library using ribosome display technology. A cDNA library of V(HH)s was constructed from lymphocytes of a non-immunized llama and engine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab76bf7eff3a3f045fd747f58fc981e5
https://doi.org/10.1016/j.jim.2003.07.011
https://doi.org/10.1016/j.jim.2003.07.011