Výsledky vyhledávání - "Maria, Dumitrascuta"

Akademický článek

Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice

Autor: Maria Dumitrascuta, Charlotte Martin, Steven Ballet, Mariana Spetea

Publikováno v: Molecules, Vol 27, Iss 24, p 8785 (2022)

There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs. Prescription

Externí odkaz: https://doaj.org/article/9931d7c9ca14407e88471dc1a03c3718

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking

Autor: Maria Dumitrascuta, Marcel Bermudez, Olga Trovato, Jolien De Neve, Steven Ballet, Gerhard Wolber, Mariana Spetea

Publikováno v: Molecules, Vol 26, Iss 11, p 3267 (2021)

Opioids are the most effective analgesics, with most clinically available opioids being agonists to the µ-opioid receptor (MOR). The MOR is also responsible for their unwanted effects, including reward and opioid misuse leading to the current public

Externí odkaz: https://doaj.org/article/cf0ea917f0194797b4d8986faa2d4631

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the Mu Opioid Receptor

Autor: Maria Dumitrascuta, Marcel Bermudez, Steven Ballet, Gerhard Wolber, Mariana Spetea

Publikováno v: Molecules, Vol 25, Iss 9, p 2087 (2020)

The mu opioid receptor (MOR) is the primary target for analgesia of endogenous opioid peptides, alkaloids, synthetic small molecules with diverse scaffolds, and peptidomimetics. Peptide-based opioids are viewed as potential analgesics with reduced si

Externí odkaz: https://doaj.org/article/85cd8759a62b46fa8adb6ffb1d6cb1a5

Zobrazit plný text záznamu

Plný text ve formátu HTML

Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies

Autor: Simon Gonzalez, Dirk Tourwé, Philippe Sarret, Mariana Spetea, Florine Cavelier, Santo Previti, Charlotte Martin, Linda Kunze, Mélanie Vivancos, Stevany Louis, Louis Gendron, Elke Dewolf, Maria Dumitrascuta, Steven Ballet, Emilie Eiselt, Annalisa Blasiol

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (21), pp.12929-12941. ⟨10.1021/acs.jmedchem.0c01376⟩

International audience; Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-D-Arg-Aba-β-Ala-NH 2 (KGOP01) was fused t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d847dbf764c975a594956d0282309fc
https://biblio.vub.ac.be/vubir/optimized-opioidneurotensin-multitarget-peptides-from-design-to-structureactivity-relationship-studies(b5565787-3be0-4e48-8dac-9092ed30584e).html

Zobrazit plný text záznamu

A refined rat primary neonatal microglial culture method that reduces time, cost and animal use

Autor: Marieta Georgieva, Wenlong Huang, Alasdair Leeson-Payne, Maria Dumitrascuta, Marzia Malcangio, Ann M. Rajnicek

Publikováno v: Georgieva, M, Leeson-Payne, A, Dumitrascuta, M, Rajnicek, A, Malcangio, M & Huang, W 2018, ' A refined rat primary neonatal microglial culture method that reduces time, cost and animal use ', Journal of Neuroscience Methods . https://doi.org/10.1016/j.jneumeth.2018.04.017

Background Primary microglial cultures have been used extensively to facilitate the development of therapeutic strategies for a variety of CNS disorders including neurodegeneration and neuropathic pain. However, existing techniques for culturing thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7af3067b21b104280bb706ed6e0ec82
https://doi.org/10.1016/j.jneumeth.2018.04.017

Zobrazit plný text záznamu

Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury

Autor: Nanna B. Finnerup, Wenlong Huang, Roger G. Pertwee, Yuting Wei, Marieta Georgieva, Maria Dumitrascuta

Publikováno v: Georgieva, M, Wei, Y, Dumitrascuta, M, Pertwee, R, Finnerup, N B & Huang, W 2019, ' Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury ', Pain, vol. 160, no. 12, pp. 2724-2742 . https://doi.org/10.1097/j.pain.0000000000001670

About half of patients with spinal cord injury (SCI) develop debilitating central neuropathic pain (CNP), with no effective treatments. Thus, effective, safe, and novel therapies are needed urgently. Previously, docosahexaenoic acid (DHA) was reporte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2475aa083325561f5c6e7c5dfb72a48
https://pure.au.dk/portal/da/publications/fatty-acid-suppression-of-glial-activation-prevents-central-neuropathic-pain-after-spinal-cord-injury(5b964788-e355-4dc7-9e18-4086aa383427).html

Zobrazit plný text záznamu

Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides

Autor: Maria Dumitrascuta, Dominik Bucher, Katja Walker, Mariana Spetea, Ann Van Eeckhaut, Morgane Mannes, Sophie Hernot, Yannick Van Wanseele, Richard Hoogenboom, Aquilino Lantero, Edith Oyen, Annemieke Madder, Charlotte Martin, Steven Ballet

Publikováno v: JOURNAL OF MEDICINAL CHEMISTRY

Chronic pain is currently treated with opioids that offer unsatisfactory long-term analgesia and produce serious side effects. There is a clear need for alternative therapies. Herein, peptide-based hydrogels are used as extended-release drug delivery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b9ef388a0d259fe5b7b69cf38f963d
https://pubmed.ncbi.nlm.nih.gov/30351003

Zobrazit plný text záznamu

A bifunctional biased mu opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects

Autor: Steven Ballet, Armand Drieu la Rochelle, Pieter Mampuys, Valérie Utard, Frédéric Bihel, Séverine Schneider, Mariana Spetea, François Daubeuf, Karel Guillemyn, Tom Willemse, Maria Dumitrascuta, Nelly Frossard, Bert U. W. Maes, Raphaëlle Quillet, Charlotte Martin, Frédéric Simonin

Publikováno v: Pain
PAIN
PAIN, Elsevier, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩

Opioid analgesics, such as morphine, oxycodone and fentanyl, are the cornerstones for treating moderate to severe pain. However, upon chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c453b72695ed1438ea7ad7e1b1b004b1
https://hdl.handle.net/10067/1506770151162165141

Zobrazit plný text záznamu

Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists

Autor: Maria, Dumitrascuta, Tanila, Ben Haddou, Elena, Guerrieri, Stefan M, Noha, Lea, Schläfer, Helmut, Schmidhammer, Mariana, Spetea

Publikováno v: Journal of Medicinal Chemistry

Position 6 of the morphinan skeleton plays a key role in the μ-opioid receptor (MOR) activity in vitro and in vivo. We describe the consequence of the 6-carbonyl group deletion in N-methylmorphinan-6-ones 1–4 on ligand–MOR interaction, signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79b5b040f59c3345eb1b02f4505a6477
https://pubmed.ncbi.nlm.nih.gov/29053268

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání