Výsledky vyhledávání - "Maria, Brattsand"

Akademický článek

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif.

Autor: Xingchen Chen, Blake T Riley, Simon J de Veer, David E Hoke, Jessica Van Haeften, Darren Leahy, Joakim E Swedberg, Maria Brattsand, Perry J Hartfield, Ashley M Buckle, Jonathan M Harris

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210842 (2019)

Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop is

Externí odkaz: https://doaj.org/article/ff0580b312cb47f5b9a6eca710bfcd0a

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Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328

Autor: Helena Järemo, Julius Semenas, Sofia Halin Bergström, Marie Lundholm, Elin Thysell, Anders Widmark, Sead Crnalic, Erik Bovinder Ylitalo, Anders Bergh, Maria Brattsand, Pernilla Wikström

Publikováno v: Cancers; Volume 15; Issue 9; Pages: 2437

MicroRNAs (miRNAs) are aberrantly expressed in prostate cancer (PC), but comprehensive knowledge about their levels and function in metastatic PC is lacking. Here, we explored the differential expression of miRNA profiles during PC progression to bon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25589eafb85da4ed94258ee6e48fecf2
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-209116

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Akademický článek

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.

Autor: Petr Kasparek, Zuzana Ileninova, Olga Zbodakova, Ivan Kanchev, Oldrich Benada, Karel Chalupsky, Maria Brattsand, Inken M Beck, Radislav Sedlacek

Publikováno v: PLoS Genetics, Vol 13, Iss 1, p e1006566 (2017)

Netherton syndrome (NS) is a severe skin disease caused by the loss of protease inhibitor LEKTI, which leads to the dysregulation of epidermal proteases and severe skin-barrier defects. KLK5 was proposed as a major protease in NS pathology, however i

Externí odkaz: https://doaj.org/article/bd44d971be1a4155b195a02dcfec4518

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KLK4T2 Is a Hormonally Regulated Transcript from the KLK4 Locus

Autor: Åke Lundwall, Pernilla Wikström, Erik Bovinder Ylitalo, Maria Brattsand

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13023, p 13023 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13023

The human kallikrein-related peptidase 4 (KLK4) and the transcribed pseudogene KLKP1 are reported to be highly expressed in the prostate. When trying to clone transcripts of KLKP1, we partly failed. Instead, we identified an androgen-regulated transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0b556003982e4644ccab3f084def98
https://www.mdpi.com/1422-0067/22/23/13023

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Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti‐androgens

Autor: Andreas Josefsson, Camilla Thellenberg-Karlsson, Erik Bovinder Ylitalo, Elin Thysell, Marie Lundholm, Anders Widmark, Pernilla Wikström, Anders Bergh, Maria Brattsand

Publikováno v: The Prostate

Background Taxane treatment may be a suitable therapeutic option for patients with castration‐resistant prostate cancer and high expression of constitutively active androgen receptor variants (AR‐Vs). The aim of the study was to compare the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c318155cddc1145ef5291716464a411c
https://doi.org/10.1002/pros.23935

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A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer

Autor: Elin Thysell, Erik Bovinder Ylitalo, Anders Bergh, Emma Jernberg, Sofie Degerman, Sead Crnalic, Pernilla Wikström, Mattias Landfors, Magnus Hultdin, Anders Widmark, Maria Brattsand

Publikováno v: Clinical Epigenetics

Background Patients with metastatic prostate cancer (PC) are treated with androgen deprivation therapy (ADT) that initially reduces metastasis growth, but after some time lethal castration-resistant PC (CRPC) develops. A better understanding of the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc80edf0a6395c7899aaf781c6ca1bc0
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185893

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Doxycycline at Low Concentrations Could Influence Your Experimental Results When Working With Prostate Cancer Cell Lines

Autor: Maria Brattsand

Publikováno v: Biomedical Journal of Scientific & Technical Research. 28

Doxycycline is a tetracycline derivate commonly used in various inducible expression systems to study the function of different proteins. In this study, we show that 22Rv1 and PC3, two different, commonly used prostate cancer cell lines are very sens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270558452463d0cd6b55ae7ed682136a
https://doi.org/10.26717/bjstr.2020.28.004636

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High levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein CodingYIPF6inARAmplified Prostate Cancer Bone Metastases

Autor: Erik Djusberg, Anders Widmark, Sead Crnalic, Emma Jernberg, Pia Lundberg, Maria Brattsand, Pernilla Wikström, Anders Bergh, Irina Golovleva, Elin Thysell

Publikováno v: The Prostate. 77:625-638

BACKGROUND: The relation between androgen receptor (AR) gene amplification and other mechanisms behind castration-resistant prostate cancer (CRPC), such as expression of constitutively active AR va ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee5736e54cba26df0f1a2af04c7f5d3d
https://doi.org/10.1002/pros.23307

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Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

Autor: Maria Brattsand, Joakim E. Swedberg, Laetitia Furio, Alain Hovnanian, Judith A. Clements, Jonathan M. Harris, Simon J. de Veer, Christopher A. Munro

Publikováno v: Journal of Investigative Dermatology. 137:430-439

Proteases have pivotal roles in the skin's outermost layer, the epidermis. In the stratum corneum, serine proteases from the kallikrein-related peptidase (KLK) family have been implicated in several key homeostatic processes, including desquamation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafdf109aa91d3c0b32532862f651b4a
https://doi.org/10.1016/j.jid.2016.09.017

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A Versatile and Robust Serine Protease Inhibitor Scaffold from

Autor: Xingchen, Chen, Darren, Leahy, Jessica, Van Haeften, Perry, Hartfield, Peter J, Prentis, Chloé A, van der Burg, Joachim M, Surm, Ana, Pavasovic, Bruno, Madio, Brett R, Hamilton, Glenn F, King, Eivind A B, Undheim, Maria, Brattsand, Jonathan M, Harris

Publikováno v: Marine Drugs

Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81867c3d6e88db82a327f14a1ad162f1
https://pubmed.ncbi.nlm.nih.gov/31842369

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