Zobrazeno 1 - 10
of 12
pro vyhledávání: '"MariJean Eggen"'
Autor:
Gunda I. Georg, MariJean Eggen
Publikováno v:
Medicinal Research Reviews. 22:85-101
The cryptophycins are a unique family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. Their molecular target is tubulin protein wherein they are the most potent known stabilizers of microtubule dynamics and depo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cc5d31cad0ff80afa957ccac0be473
https://doi.org/10.1002/med.10002
https://doi.org/10.1002/med.10002
Autor:
Syed M. Ali, Emily A. Reiff, Gunda I. Georg, Craig J. Mossman, MariJean Eggen, Suzanne B. Buck, Laxminarayan Bhat, Thomas C. Boge, Sajiv K. Nair
Publikováno v:
The Journal of Organic Chemistry. 65:7792-7799
Two efficient protocols for the synthesis of tert-butyl (5S,6R,2E, 7E)-5-[(tert-butyldimethylsilyl)oxy]-6-methyl-8-phenyl-2, 7-octadienoate, a major component of the cryptophycins, are reported. The first utilized the Noyori reduction and Frater alky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d0daca9684a5b15516988e5b43587d8
https://doi.org/10.1021/jo000767+
https://doi.org/10.1021/jo000767+
Publikováno v:
The Journal of Organic Chemistry. 61:4666-4675
In addition to the previously recorded reactions of diethyl lithio(difluoromethyl)phosphonate (8) with primary triflates and aldehydes, we report here that 8 reacts with functionalized, but unactivated, methyl esters to give efficient acyl substituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad27bcc4a29d09cef88e27bc97e0d48
https://doi.org/10.1021/jo9604752
https://doi.org/10.1021/jo9604752
Autor:
Larry Oien, Chad C. Stessman, Sung-Gyu Kim, James W. Christensen, MariJean Eggen, Mukund P. Sibi
Publikováno v:
Tetrahedron Letters. 36:6209-6212
The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0689cbe812ffea6ce66dc23fff2bbe89
https://doi.org/10.1016/0040-4039(95)01251-c
https://doi.org/10.1016/0040-4039(95)01251-c
Publikováno v:
ChemInform. 25
Simple primary alkyl triflates and those derived from several monosaccharides are cleanly displaced by diethyl (lithiodifluoromethyl)phosphonate to provide the corresponding (α,α-difluoroallyl)phosphonates in minutes at -78 o C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1492f9188b883722139454152b231feb
https://doi.org/10.1002/chin.199409059
https://doi.org/10.1002/chin.199409059
Autor:
MariJean Eggen, Chad C. Stessman, James W. Christensen, Mukund P. Sibi, Larry Oien, Sung-Gyu Kim
Publikováno v:
ChemInform. 26
The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95b9dede8672e806c54fd5b587961b25
https://doi.org/10.1002/chin.199550029
https://doi.org/10.1002/chin.199550029
Publikováno v:
ChemInform. 27
In addition to the previously recorded reactions of diethyl lithio(difluoromethyl)phosphonate (8) with primary triflates and aldehydes, we report here that 8 reacts with functionalized, but unactivated, methyl esters to give efficient acyl substituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fe1d59efeada97d9dedfb4a367d91fd
https://doi.org/10.1002/chin.199646220
https://doi.org/10.1002/chin.199646220
Autor:
Gunda I. Georg, MariJean Eggen
Publikováno v:
ChemInform. 33
The cryptophycins are a unique family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. Their molecular target is tubulin protein wherein they are the most potent known stabilizers of microtubule dynamics and depo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e780e9ed71cec3eedab5324fce6bc7ff
https://doi.org/10.1002/chin.200221248
https://doi.org/10.1002/chin.200221248
Autor:
Roger J. Brideau, David J. Anderson, Steven P. Tanis, Michael J. Genin, Euibong J. Kim, Nancee L. Oien, James A. Nieman, Mark E. Schnute, Valerie A. Vaillancourt, Allen Scott, Thomas M. Judge, Fred L. Ciske, Mary L. Knechtel, Sajiv Krishnan Nair, Marijean Eggen, Michele M. Cudahy, Sarah A. Collier, Janet L. Wieber, Michael W. Wathen, Todd A. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c003e07737e19e2a8033c8a023d0a5f
https://pubmed.ncbi.nlm.nih.gov/17434304
https://pubmed.ncbi.nlm.nih.gov/17434304
Publikováno v:
The Journal of Organic Chemistry. 58:6174-6176
Simple primary alkyl triflates and those derived from several monosaccharides are cleanly displaced by diethyl (lithiodifluoromethyl)phosphonate to provide the corresponding (α,α-difluoroallyl)phosphonates in minutes at -78 o C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a966d820438ded692b520605c96b42
https://doi.org/10.1021/jo00075a005
https://doi.org/10.1021/jo00075a005