Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mari Tomonari"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 2, Pp 112-120 (2012)
We previously reported that higher therapeutic effects were obtained in rheumatoid arthritis (RA) patients and RA model animals when the dosing-times of methotrexate and tacrolimus were chosen according to the 24-h rhythms of the inflammatory respons
Externí odkaz:
https://doaj.org/article/75e6c2675dc84f22a985d6b20ad06319
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 3, Pp 336-345 (2011)
We revealed that pre-treatment with docetaxel (DOC) 12 h before adriamycin (ADR) administration significantly reduced ADR-induced toxic death compared with the simultaneous dosing schedule that was commonly used in previous studies. We considered tha
Externí odkaz:
https://doaj.org/article/34d2fac0d8694cc09d4ac980939b4b5d
Autor:
Kayo Obayashi, Mari Tomonari, Hiromichi Yoshimatsu, Ryuji Fukuyama, Ichiro Ieiri, Shun Higuchi, Hideto To
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 3, Pp 264-273 (2011)
Abstract.: Stiffness and cytokine in blood levels show 24-h rhythms in rheumatoid arthritis (RA) patients. We previously revealed that higher therapeutic effects were obtained in RA patients and RA model animals when the dosing time of methotrexate w
Externí odkaz:
https://doaj.org/article/e3566311a4b2425a8e6037cf6701e195
Publikováno v:
Chronobiology international. 37(11)
Although many basic and clinical studies have shown that glucosamine (GlcN) improves osteoarthritis, it has not been widely used in the clinic because its bioavailability is only 6%. We investigated the influence of dosing-time factors, which influen
Autor:
Atsushi Kawakami, Hiromichi Yoshimatsu, Hiroaki Ida, Hitoshi Sasaki, Hideto To, Satoru Koyanagi, Ichiro Ieiri, Toshiyuki Tsurumoto, Katsumi Eguchi, Shun Higuchi, Emi Sonemoto, Noriko Shimasaki, Yukitaka Ueki, Yasuhiro Tsuji, Mari Tomonari
Publikováno v:
Chronobiology International. 28:267-274
Methotrexate (MTX) is the most important drug for treating rheumatoid arthritis (RA). It has been stated that cytokines play an important role in the pathogenesis of RA, and that cytokine levels increase and show 24-h rhythms in RA patients. Previous
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 3, Pp 336-345 (2011)
We revealed that pre-treatment with docetaxel (DOC) 12 h before adriamycin (ADR) administration significantly reduced ADR-induced toxic death compared with the simultaneous dosing schedule that was commonly used in previous studies. We considered tha
Autor:
Ryuji Fukuyama, Shun Higuchi, Kayo Obayashi, Ichiro Ieiri, Hiromichi Yoshimatsu, Mari Tomonari, Hideto To
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 3, Pp 264-273 (2011)
Stiffness and cytokine in blood levels show 24-h rhythms in rheumatoid arthritis (RA) patients. We previously revealed that higher therapeutic effects were obtained in RA patients and RA model animals when the dosing time of methotrexate was chosen a
Autor:
Kaname Ohyama, Kenichiro Nakashima, Mari Tomonari, Tomoko Ichibangase, Hideto To, Kazuhiro Imai, Naotaka Kuroda, Naoya Kishikawa
Publikováno v:
Biochemical pharmacology. 80(4):540-547
Studies suggest that pre-administration of docetaxel (DOC) in adriamycin (ADR)-DOC combination anticancer therapy results in stronger antitumor effects and fewer ADR-induced cardiotoxic deaths in mouse model, yet no mechanism explaining this effect h
Autor:
Masashi Wanifuchi, Aya Takahara, Yoshihiro Seto, Fumiyasu Okazaki, Shunsuke Takakura, Mari Tomonari, Hideto To
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO2-2
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:1333-1338
Objectives Rheumatoid arthritis is an autoimmune disorder of unknown aetiology. Morning stiffness, a characteristic feature of rheumatoid arthritis, shows a 24-h rhythm. Noticing this rhythm, we hypothesized the presence of a similar rhythm for a rhe