Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Mari Thomas"'
Autor:
Nishkantha Arulkumaran, Mari Thomas, Matthew Stubbs, Nithya Prasanna, Maryam Subhan, Deepak Singh, Gareth Ambler, Alessia Waller, Mervyn Singer, David Brealey, Marie Scully
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract COVID-19 disease is associated with a hyperinflammatory, pro-thrombotic state and a high mortality. Our primary objective was to assess the change in inflammatory and thrombotic markers associated with PEX, and secondary objectives were to a
Externí odkaz:
https://doaj.org/article/1919a2c7973b4cd2903a156e3d813f46
Autor:
Yishi Tan, Marc Carrier, Nicola Curry, Michael Desborough, Kathryn Musgrave, Marie Scully, Tzu-Fei Wang, Mari Thomas, Simon J. Stanworth
Publikováno v:
Bleeding, Thrombosis and Vascular Biology, Vol 3, Iss s1 (2024)
Individuals who have thrombocytopenia and cancer-associated thrombosis (CAT) are difficult to manage because they have a high risk of bleeding and recurrent thrombosis. The International Society on Thrombosis and Haemostasis guidelines for the manage
Externí odkaz:
https://doaj.org/article/6f61d65acb31462687fe55d0a816c0e1
Autor:
Ferras Alwan, Chiara Vendramin, Ulrich Budde, Ri Liesner, Alice Taylor, Mari Thomas, Bernhard Lämmle, Marie Scully
Publikováno v:
eJHaem, Vol 2, Iss 2, Pp 188-195 (2021)
Abstract Despite clinical remission and normal platelet counts, congenital TTP (cTTP) is associated with non‐overt symptoms. Prophylactic ADAMTS13 replacement therapy such as plasma infusion (PI) prevents acute episodes and improves symptomatology.
Externí odkaz:
https://doaj.org/article/efd643c2340641c089b1ae2edf1e55ce
Autor:
Nishkantha Arulkumaran, Mari Thomas, David Brealey, Ferras Alwan, Deepak Singh, Michael Lunn, Anna Welch, Samuel Clark, Eamon Raith, Ugan Reddy, Ryan Low, David Leverett, Mervyn Singer, Marie Scully
Publikováno v:
eJHaem, Vol 2, Iss 1, Pp 26-32 (2021)
Abstract Severe COVID‐19 disease is a hyperinflammatory, pro‐thrombotic state. We undertook plasma exchange (PEX) to determine its effects on organ function and thrombo‐inflammatory markers. Seven critically ill adults with severe COVID‐19 re
Externí odkaz:
https://doaj.org/article/43fb2ba29e694399b1dc8176e2fb3c76
Autor:
Matthew J. Stubbs, Paul Coppo, Chris Cheshire, Agnès Veyradier, Stephanie Dufek, Adam P. Levine, Mari Thomas, Vaksha Patel, John O. Connolly, Michael Hubank, Ygal Benhamou, Lionel Galicier, Pascale Poullin, Robert Kleta, Daniel P. Gale, Horia Stanescu, Marie A. Scully
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Immune thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare, life-threatening disorder, mediated through severe ADAMTS13 deficiency causing multi-system micro-thrombi formation, and has specific human leukocyte antigen associations. We underto
Externí odkaz:
https://doaj.org/article/c7854f9589c04f2cbc48c27590f492a9
Autor:
John-Paul Westwood, Mari Thomas, Ferras Alwan, Vickie McDonald, Sylvia Benjamin, William A. Lester, Gillian C. Lowe, Tina Dutt, Quentin A. Hill, Marie Scully
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1159-1166 (2017)
Abstract: Acute antibody-mediated thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy with high morbidity and mortality. Rituximab is highly effective as prophylaxis in patients at risk of acute TTP relapse, but the ideal dosing
Externí odkaz:
https://doaj.org/article/039675966e174eba8bed33687e100d8d
Publikováno v:
TH Open, Vol 02, Iss 03, Pp e329-e333 (2018)
A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Externí odkaz:
https://doaj.org/article/cae5339a63394176bb9c2e2a2cb7536e
Publikováno v:
European Medical Journal. :30-39
This symposium took place during the International Society on Thrombosis and Haemostasis (ISTH) Congress, 2022. Ajay Kakkar, Thrombosis Research Institute, London, UK, opened the symposium by highlighting the extent to which patients with cancer are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a7781e7cd69ab7cbc3f78ba2995a1b
https://doi.org/10.33590/emj/10175843
https://doi.org/10.33590/emj/10175843
Autor:
Jin-Sup Shin, Maryam Owais Subhan, Geraldine Cambridge, Yanping Guo, Rens de Groot, Marie Scully, Mari Thomas
Publikováno v:
Blood Advances. 6:3792-3802
T follicular helper (Tfh) cells regulate development of antigen-specific B-cell immunity. We prospectively investigated B-cell and circulating Tfh (cTfh) cell subsets in 45 patients with immune thrombotic thrombocytopenic purpura (iTTP) at presentati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139bfbf5f1fbc1186d18415dd1606235
https://doi.org/10.1182/bloodadvances.2022007025
https://doi.org/10.1182/bloodadvances.2022007025
Autor:
Nithya Prasannan, Mari Thomas, Matthew James Stubbs, John-Paul Westwood, Rens de Groot, Deepak Singh, Marie Scully
Publikováno v:
Blood.
The benefits of caplacizumab in acute immune mediated TTP (iTTP) are well established. We identified a delay in normalisation of ADAMTS13 activity (>30%) in a subgroup of caplacizumab treated patients which was not evident in the pre-caplacizumab era
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0a0f3488da7e5eb027d49fe669078a
https://doi.org/10.1182/blood.2022018847
https://doi.org/10.1182/blood.2022018847