Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mari Takaai"'
Autor:
Mari Takaai, Mikiya Fujieda, Takuhito Nagai, Naohiro Wada, Masayoshi Yamada, Masaki Shimizu, Takuji Yamada, Yoshimitsu Gotoh, Masashi Morooka, Kazuhide Ohta, Yukiya Hashimoto, Osamu Uemura, Hisashi Kaneda, Katsumi Ushijima, Kenichi Satomura
Publikováno v:
Clinical and Experimental Nephrology. 20:757-763
The present study aimed to obtain information enabling optimisation of the clinical effect of mizoribine (MZR) in pediatric patients with kidney disease. A total of 105 pediatric patients with kidney disease treated at our institutions were enrolled.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f660e50a5173727e2c3fd2f3ac83849e
https://doi.org/10.1007/s10157-015-1209-9
https://doi.org/10.1007/s10157-015-1209-9
Autor:
Masaki Shimizu, Masayoshi Yamada, Takuji Yamada, Hisashi Kaneda, Katsumi Ushijima, Osamu Uemura, Kazuya Ishida, Mari Takaai, Naohiro Wada, Yukiya Hashimoto, Masashi Morooka, Kazuhide Ohta, Yoshimitsu Goto, Kenichi Satomura, Mikiya Fujieda
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:71-78
The aim of this study was to evaluate limited sampling designs to estimate the maximal concentration (C(max)) and area under the curve (AUC) of mizoribine in pediatric patients with renal disease. We utilized 48 serum mizoribine concentration profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d96b38736a7807a93d8edb002e891da
https://doi.org/10.2133/dmpk.dmpk-10-rg-077
https://doi.org/10.2133/dmpk.dmpk-10-rg-077
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 36:63-71
To investigate the intestinal absorption mechanisms of methotrexate,we examined the apical uptake and transcellular transport of the drug in human intestinal epithelial Caco-2 cells.In these cells,the mRNA expression of proton-coupled folate transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fdea97b0a267cc6bffd4aa6fdd93d62
https://doi.org/10.5649/jjphcs.36.63
https://doi.org/10.5649/jjphcs.36.63
Publikováno v:
Biological & Pharmaceutical Bulletin. 32:741-745
The aim of the present study was to characterize membrane transport mechanisms of mizoribine in the intestinal epithelial cells. We evaluated the contribution of Na(+)-dependent and -independent membrane transporters to mizoribine absorption in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ccca94e0e800febfd02187e18defbf
https://doi.org/10.1248/bpb.32.741
https://doi.org/10.1248/bpb.32.741
Publikováno v:
Drug Metabolism and Pharmacokinetics. 23:128-133
Summary: In the previous study, we performed a simulation of a clinical pharmacokinetic trial, in which blood was sampled at two time points corresponding to the peak concentration (C peak ) and trough concentration (C trough ) following repetitive o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6858890623d4f8dc78b21485bd12ee
https://doi.org/10.2133/dmpk.23.128
https://doi.org/10.2133/dmpk.23.128
Publikováno v:
Drug Metabolism and Pharmacokinetics. 23:340-346
To evaluate the mechanism responsible for the tubular secretion of bisoprolol, we compared transcellular transport of bisoprolol with that of tetraethylammonium (TEA), cimetidine, and quinidine across LLC-PK1 cell monolayers grown on porous membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3662be5c7bed022fa88fd7f9386d3a3
https://doi.org/10.2133/dmpk.23.340
https://doi.org/10.2133/dmpk.23.340
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:2167-2172
To characterize the membrane transport responsible for the renal excretion and intestinal absorption of levofloxacin, we performed pharmacokinetic analysis of transcellular transport across LLC-PK(1) and Caco-2 cell monolayers. Transcellular transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf64e43ec86c883949e6ae14bd0ad294
https://doi.org/10.1248/bpb.30.2167
https://doi.org/10.1248/bpb.30.2167
Autor:
Miki Masago, Asuka Horie, Toshikazu Ito, Mari Takaai, Jumpei Sakata, Masato Taguchi, Kazuya Ishida, Yukiya Hashimoto
Publikováno v:
Biologicalpharmaceutical bulletin. 33(8)
The aim of the present study was to compare the membrane transport mechanisms of procainamide with those of quinidine using renal epithelial LLC-PK(1) and intestinal epithelial LS180 cells. In LLC-PK(1) cells, the transcellular transport of 10 microM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f707fa45893e2e1382b3acddbc166b
https://pubmed.ncbi.nlm.nih.gov/20686239
https://pubmed.ncbi.nlm.nih.gov/20686239
Autor:
Shiro Fukumori, Katsutoshi Tahara, Masato Taguchi, Toshiya Murata, Yukiya Hashimoto, Mari Takaai
Publikováno v:
Drug metabolism and pharmacokinetics. 23(5)
The aim of this study was to investigate the involvement of the peptide transporter for absorption of levofloxacin in Caco-2 cells. To evaluate the activity of apical and basolateral peptide transport, we first performed pharmacokinetic analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8742fd2583e92a837c9a17a19f24c1
https://pubmed.ncbi.nlm.nih.gov/18974615
https://pubmed.ncbi.nlm.nih.gov/18974615
Autor:
Mari Takaai, Tomoo Funaki, Toshiko Koue, Junichi Azuma, Yuichiro Kayano, Masanori Kubo, Tsuyoshi Fukuda, Yukiya Hashimoto
Publikováno v:
Biologicalpharmaceutical bulletin. 30(11)
The population pharmacokinetic parameters of aripiprazole in healthy Japanese males were estimated using a nonlinear mixed effects model (NONMEM) program. Pharmacokinetic data for population analysis were obtained from the single-dose (24 subjects),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9862cdd17b9cef82ce7380d23437d
https://pubmed.ncbi.nlm.nih.gov/17978491
https://pubmed.ncbi.nlm.nih.gov/17978491