EVOBRUTINIB TREATMENT REDUCES THE DAMAGE TO THE CNS AND INCREASES THE NUMBER OF CLASSICAL DENDRITIC CELLS IN EXPERIMENTAL MULTIPLE SCLEROSIS

Autor: Mari Paz Serrano-Regal, Leticia Calahorra, Inmaculada Alonso-García, Ursula Boschert, Philipp Haselmayer, María Cristina Ortega, Isabel Machin-Diaz, Celia Camacho-Toledano, Jennifer García-Arocha, Diego Clemente

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S272-S273 (2023)

Externí odkaz: https://doaj.org/article/dc97177e5f804c3a870196ab8fda9aa9

Expression and Function of GABA Receptors in Myelinating Cells

Autor: Mari Paz Serrano-Regal, Laura Bayón-Cordero, Rainald Pablo Ordaz, Edith Garay, Agenor Limon, Rogelio O. Arellano, Carlos Matute, María Victoria Sánchez-Gómez

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

Myelin facilitates the fast transmission of nerve impulses and provides metabolic support to axons. Differentiation of oligodendrocyte progenitor cells (OPCs) and Schwann cell (SC) precursors is critical for myelination during development and myelin

Externí odkaz: https://doaj.org/article/7b565646b2d34807a73148acb273f66d

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

Autor: Manuel Canedo-Antelo, Mari Paz Serrano, Andrea Manterola, Asier Ruiz, Francisco Llavero, Susana Mato, José Luis Zugaza, Fernando Pérez-Cerdá, Carlos Matute, María Victoria Sánchez-Gómez

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Oligodendrocytes are highly vulnerable to glutamate excitotoxicity, a central mechanism involved in tissue damage in Multiple Sclerosis (MS). Sustained activation of AMPA receptors in rat oligodendrocytes induces cytosolic calcium overload, mitochond

Externí odkaz: https://doaj.org/article/c89429a52d854e3aba2f9107b1259128

Evobrutinib therapeutic response is associated with an increase in the number and maturation of peripheral and central classical dendritic cells (P7-3.005)

Autor: Diego Clemente, Mari Paz Serrano-Regal, Leticia Calahorra, Inmaculada Alonso-García, Ursula Boschert Shafaatian, Philipp Haselmayer, Cristina Ortega, Isabel Machín-Díaz, Celia Camacho-Toledano, Jennifer García-Arocha

Publikováno v: Tuesday, April 25.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e718a8d39238fd8098d62dff10c6739
https://doi.org/10.1212/wnl.0000000000203675

A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling

Autor: Adhara Gaminde-Blasco, Mari Paz Serrano-Regal, Jorge Valero, Jimena Baleriola, María Victoria Sánchez-Gómez, Elena Alberdi, Tania Quintela-López, Carlos Matute, Carolina Ortiz-Sanz

Publikováno v: Cell Death and Disease, Vol 10, Iss 6, Pp 1-16 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Cell Death & Disease

Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the onset of neurodegeneration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5ab03bd06f2185a23130ee07c1bfb9
http://hdl.handle.net/10810/41430