Gradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning

Autor: Mari N. Willeman, Monica K. Chawla, Marc A. Zempare, Lauren A Biwer, Lan T. Hoang, Ajay R. Uprety, Megan C. Fitzhugh, Matthew De Both, Paul D. Coleman, Theodore P. Trouard, Gene E. Alexander, Kenneth D. Mitchell, Carol A. Barnes, Taben M. Hale, Matthew Huentelman

Publikováno v: Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)

Abstract Hypertension is a major health concern in the developed world, and its prevalence increases with advancing age. The impact of hypertension on the function of the renal and cardiovascular systems is well studied; however, its influence on the

Externí odkaz: https://doaj.org/article/76adeb50b6b241eeacdba5989ffac95c

Evaluations of memory, anxiety, and the growth factor IGF-1R after post-surgical menopause treatment with a highly selective progestin

Autor: Victoria E. Bernaud, Stephanie V. Koebele, Steven N. Northup-Smith, Mari N. Willeman, Charlotte Barker, Alex Schatzki-Lumpkin, Maria Valenzuela Sanchez, Heather A. Bimonte-Nelson

Publikováno v: Behavioural Brain Research. 448:114442

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a75717dd8503d7d36b0b49ae612e93e6
https://doi.org/10.1016/j.bbr.2023.114442

The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats

Autor: Matthew J. Huentelman, Matt De Both, Jason Caselli, Jason J. Corneveaux, Lauren T. Hewitt, Mari N. Willeman, Ashley L. Siniard, Candy W. S. Tsang, Heather A. Bimonte-Nelson, B. Blair Braden, Sarah E. Mennenga

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198256 (2018)

Enzastaurin is a Protein Kinase C-β selective inhibitor that was developed to treat cancers. Protein Kinase C-β is an important enzyme for a variety of neuronal functions; in particular, previous rodent studies have reported deficits in spatial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c81361726f854bf802e762a01a7837
http://europepmc.org/articles/PMC5988320

Gradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning.

Autor: Willeman, Mari N.^1,2,3 (AUTHOR), Chawla, Monica K.^1,3 (AUTHOR), Zempare, Marc A.^1,3 (AUTHOR), Biwer, Lauren A⁴ (AUTHOR), Hoang, Lan T.^1,3 (AUTHOR), Uprety, Ajay R.^1,3 (AUTHOR), Fitzhugh, Megan C.^1,3,5 (AUTHOR), De Both, Matthew^2,3 (AUTHOR), Coleman, Paul D.^3,6 (AUTHOR), Trouard, Theodore P.^1,7 (AUTHOR), Alexander, Gene E.^1,3,5,8 (AUTHOR), Mitchell, Kenneth D.⁹ (AUTHOR), Barnes, Carol A.^1,3,5 (AUTHOR), Hale, Taben M.⁴ (AUTHOR), Huentelman, Matthew^1,2,3 (AUTHOR) mhuentelman@tgen.org

Publikováno v: Physiological Reports. Mar2019, Vol. 7 Issue 6, pN.PAG-N.PAG. 1p.