Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Mari Luz Rosauro"'
Autor:
Mari Luz Rosauro, Kris Van Dijck, Gregory Fanning, David McGowan, Sara M. Pérez Benedicto, Bart Stoops, Pierre Jean-Marie Bernard Raboisson, Bertrand Van Schoubroeck, Wendy Mostmans, Annick Scholliers, Tine Thoné, Frederik Pauwels, Mourad Daoubi Khamlichi, Vineet Pande, Tim H. M. Jonckers, Florence Herschke, Helen Horton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3216-3221
In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure-activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high cl
Autor:
Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Werner Embrechts, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thoné, Dorien De Pooter, Gregory Fanning, Mari Luz Rosauro, Mourad Daoubi Khamlichi, Ioannis Houpis, Eric Arnoult, Tim H.M. Jonckers, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:711-719
The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the