Výsledky vyhledávání - "Mari H. Savolainen"

Akademický článek

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

Autor: Mari H. Savolainen, Christopher T. Richie, Brandon K. Harvey, Pekka T. Männistö, Kathleen A. Maguire-Zeiss, Timo T. Myöhänen

Publikováno v: Neurobiology of Disease, Vol 68, Iss , Pp 1-15 (2014)

The misfolding and aggregation of α-synuclein (aSyn) eventually lead to an accumulation of toxic forms that disturb normal neuronal function and result in cell death. aSyn rich inclusions are seen in Parkinson's disease, dementia with Lewy bodies an

Externí odkaz: https://doaj.org/article/c7bcb981635d436dbabcfad7192b26e0

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Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse

Autor: Mari H, Savolainen, Katrina, Albert, Mikko, Airavaara, Timo T, Myöhänen

Publikováno v: Experimental brain research. 235(7)

Proteinaceous inclusions, called Lewy bodies, are used as a pathological hallmark for Parkinson's disease (PD). Lewy bodies contain insoluble α-synuclein (aSyn) and many other ubiquitinated proteins, suggesting a role for protein degradation system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6097c0e272fba5d7507cf7c5b0cddf9c
https://pubmed.ncbi.nlm.nih.gov/28439627

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