Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Autor: Corinna Engel, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Ana Vilan, Mari Falck, Isabella Mauro, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht, Roselinda van der Vlught, Axel R. Franz, for the ALBINO Study Group

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-13 (2024)

Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Addit

Externí odkaz: https://doaj.org/article/d71c5fa9575d45cfb78d1b9a3eec4da1

Restraint stress during neonatal hypoxia‐ischemia alters brain injury following normothermia and hypothermia

Autor: Julia K. Gundersen, Hemmen Sabir, Thomas R. Wood, Damjan Osredkar, Mari Falck, Else M. Loeberg, Lars Walloe, David A. Menassa, Marianne Thoresen

Publikováno v: Physiological Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)

Abstract Rodent models of neonatal hypoxic–ischemic (HI) injury require a subset of animals to be immobilized for continuous temperature monitoring during the insult and subsequent treatment. Restrained animals are discarded from the analysis due t

Externí odkaz: https://doaj.org/article/24f6b6bb6a18488ea63b7c2e48920c80

Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic–ischaemic brain injury: a single laboratory meta-analysis

Autor: Lars Walløe, Thomas R. Wood, Mari Falck, Marianne Thoresen, Damjan Osredkar, Hemmen Sabir, Else Marit Løberg, Julia Kristine Gundersen, Elke Maes

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Wood, T R, Gundersen, J, Falck, M, Maes, E P J, Osredkar, D, Løberg, E M, Sabir, H, Walløe, L & Thoresen, M 2020, ' Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury : a single laboratory meta-analysis ', Scientific Reports, vol. 10, 10833 . https://doi.org/10.1038/s41598-020-67532-2

Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI) encephalopathy. However, the efficacy of HT in preclinical models, such as the Vannucci model of unilateral HI in the newborn rat, is often greater than that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bf911209b5853978bde53e670072ce
https://doaj.org/article/feb62e6a11344e0da9ff0aee5d584154

Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent

Autor: Elke Maes, Marianne Thoresen, Torun Flatebø, Damjan Osredkar, Mari Falck, Hemmen Sabir, Thomas R. Wood

Publikováno v: Falck, M, Osredkar, D, Maes, E, Flatebo, T, Wood, T, Sabir, H & Thoresen, M 2017, ' Hypothermic Neuronal Rescue from Infection-sensitised Hypoxic-Ischaemic Brain Injury is Pathogen Dependent ', Developmental Neuroscience, vol. 39, no. 1-4, pp. 238-247 . https://doi.org/10.1159/000455838

Perinatal infection increases the vulnerability of the neonatal brain to hypoxic-ischaemic (HI) injury. Hypothermia treatment (HT) does not provide neuroprotection after pre-insult inflammatory sensitisation by lipopolysaccharide (LPS), a gram-negati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8ce8b0bb870669238cafa4a45666a2
https://doi.org/10.1159/000455838

Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner

Autor: Elke Maes, Torun Flatebø, Hemmen Sabir, Marianne Thoresen, Thomas R. Wood, Damjan Osredkar, Mari Falck

Publikováno v: Falck, M, Osredkar, D, Wood, T R, Maes, E, Flatebø, T, Sabir, H & Thoresen, M 2017, ' Neonatal systemic inflammation induces inflammatory reactions and brain apoptosis in a pathogen-specific manner ', Neonatology, vol. 113, no. 3, pp. 212-220 . https://doi.org/10.1159/000481980

Background: After neonatal asphyxia, therapeutic hypothermia (HT) is the only proven treatment option. Although established as a neuroprotective therapy, benefit from HT has been questioned when infection is a comorbidity to hypoxic-ischaemic (HI) br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da660859b4f552a9e006311b5cc4cbb
https://research-information.bris.ac.uk/en/publications/neonatal-systemic-inflammation-induces-inflammatory-reactions-and