Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor-γ Sumoylation, and HIF-1α

Autor: Richard M. Wright, Mari E. Weyman, Mehdi A. Fini, Gayle N. Shibao, Hillary Fitzgerald, Nancy D. Elkins, Janice Tiao, Sophie Gibbings

Publikováno v: Gibbings, S, Elkins, N D, Fitzgerald, H, Tiao, J, Weyman, M E, Shibao, G, Fini, M A & Wright, R M 2011, ' Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1 alpha ', Journal of Biological Chemistry, vol. 286, no. 2, pp. 961-975 . https://doi.org/10.1074/jbc.M110.150847

The protective effects of pharmacological inhibitors of xanthine oxidoreductase (XOR) have implicated XOR in many inflammatory diseases. Nonetheless, the role played by XOR during inflammation is poorly understood. We previously observed that inhibit

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https://doi.org/10.1074/jbc.m110.150847