Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mari B. Ishak Gabra"'
Autor:
Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman, Mei Kong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors
Externí odkaz:
https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce
Autor:
Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale, Ziv Gil, Mei Kong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirect
Externí odkaz:
https://doaj.org/article/a9fee3fb145c4ef5be976c2f1bd995e7
Autor:
Xazmin H. Lowman, Eric A. Hanse, Ying Yang, Mari B. Ishak Gabra, Thai Q. Tran, Haiqing Li, Mei Kong
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 3051-3060.e4 (2019)
Summary: Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of glutamine, cancer cells frequently undergo glutamine starvation in vivo. We and others have
Externí odkaz:
https://doaj.org/article/436fe2b531ba49b3a816c5598a9e6dd7
Autor:
Thai Q Tran, Mari B Ishak Gabra, Xazmin H Lowman, Ying Yang, Michael A Reid, Min Pan, Timothy R O'Connor, Mei Kong
Publikováno v:
PLoS Biology, Vol 15, Iss 11, p e2002810 (2017)
Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cell
Externí odkaz:
https://doaj.org/article/8fe984b826fc4c1ebc891abb31b11995
Autor:
Dustin E. Schones, Linda Doan, Xazmin H. Lowman, Mari B. Ishak Gabra, Haiqing Li, Eric A. Hanse, Xiangdong Xu, David A. Fruman, Lishi Zhang, Ying Yang, Mei Kong, Thai Q. Tran, Parijat Senapati
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor microenvironment remain unexplored. In melanoma, tumour cells often experience low glutamine levels, which promote cell dedifferentiation. Here, we show th
Autor:
Thai Q. Tran, Amelia M. Ooi, Amber N Habowski, Marian L. Waterman, Robert Edwards, Mari B. Ishak Gabra, Haiqing Li, Xazmin H. Lowman, Ying Yang, Mei Kong, Eric A. Hanse, Shu Y. Liao
Publikováno v:
Nat Cancer
Nature cancer, vol 1, iss 3
Nature cancer, vol 1, iss 3
Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental glutamine restriction further augments Wnt signaling in APC mutant intestinal organoids to promo
Autor:
Thai Q. Tran, Mari B. Ishak Gabra, Ying Yang, Qiong A. Wang, Min Pan, Mei Kong, Eric A. Hanse, Wenzhu Liu, Bryan Ruiz, Xazmin H. Lowman
Publikováno v:
EMBO Rep
EMBO reports, vol 22, iss 8
EMBO reports, vol 22, iss 8
Adipose tissue plays a major role in maintaining organismal metabolic equilibrium. Control over the fate decision from mesenchymal stem cells (MSCs) to adipocyte differentiation involves coordinated command of phosphorylation. Protein phosphatase 2A
Autor:
Juan Liu, Ying Yang, Xazmin H. Lowman, Ziv Gil, Jason W. Locasale, Eric A. Hanse, Michael A. Reid, Mei Kong, Thai Q. Tran, Mari B. Ishak Gabra, Haiqing Li, Neta Milman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Yang, Ying; Ishak Gabra, Mari B; Hanse, Eric A; Lowman, Xazmin H; Tran, Thai Q; Li, Haiqing; et al.(2019). MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.. Nature communications, 10(1), 809. doi: 10.1038/s41467-019-08759-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/88p6h77m
Nature Communications
Yang, Ying; Ishak Gabra, Mari B; Hanse, Eric A; Lowman, Xazmin H; Tran, Thai Q; Li, Haiqing; et al.(2019). MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.. Nature communications, 10(1), 809. doi: 10.1038/s41467-019-08759-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/88p6h77m
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which PDAC cells undergo metabolic reprogramming to adapt to metabolic stress are still poorly unde
Publikováno v:
Oncogenesis, Vol 7, Iss 11, Pp 1-12 (2018)
Ishak Gabra, Mari B; Yang, Ying; Lowman, Xazmin H; Reid, Michael A; Tran, Thai Q; & Kong, Mei. (2018). IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation.. Oncogenesis, 7(11), 93. doi: 10.1038/s41389-018-0104-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2bb878w6
Oncogenesis
Ishak Gabra, Mari B; Yang, Ying; Lowman, Xazmin H; Reid, Michael A; Tran, Thai Q; & Kong, Mei. (2018). IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation.. Oncogenesis, 7(11), 93. doi: 10.1038/s41389-018-0104-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2bb878w6
Oncogenesis
One of the hallmarks of cancer is the ability to reprogram cellular metabolism to increase the uptake of necessary nutrients such as glucose and glutamine. Driven by oncogenes, cancer cells have increased glutamine uptake to support their highly prol
Autor:
Zhengtao Xiao, Grace A. Hernandez, Anh T. Phung, Kerrigan Blake, Eric Mjolsness, Zena Werb, Michelle A. Digman, Ryan T. Davis, Ying Yang, Austin E. Y. T. Lefebvre, Hamad Alshetaiwi, Devon A. Lawson, Jason W. Locasale, Mari B. Ishak Gabra, Juan Liu, Mei Kong, Dennis Ma, Dustin Maurer
Publikováno v:
Nature cell biology. 22(3)
Although metastasis remains the cause of most cancer-related mortality, mechanisms governing seeding in distal tissues are poorly understood. Here, we establish a robust method for the identification of global transcriptomic changes in rare metastati