Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain

Autor: Dario Kringel, Mari A. Kaunisto, Catharina Lippmann, Eija Kalso, Jörn Lötsch

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Background: Many gene variants modulate the individual perception of pain and possibly also its persistence. The limited selection of single functional variants is increasingly being replaced by analyses of the full coding and regulatory sequences of

Externí odkaz: https://doaj.org/article/5c05011d73e241b191bf9d3dbdce46c1

Heme oxygenase-1 repeat polymorphism in septic acute kidney injury.

Autor: Laura M Vilander, Suvi T Vaara, Kati M Donner, Päivi Lakkisto, Mari A Kaunisto, Ville Pettilä, FINNAKI Study Group

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217291 (2019)

Acute kidney injury (AKI) is a syndrome that frequently affects the critically ill. Recently, an increased number of dinucleotide repeats in the HMOX1 gene were reported to associate with development of AKI in cardiac surgery. We aimed to test the re

Externí odkaz: https://doaj.org/article/7238a124a93345c1a88b93ea4f3849eb

FinnGen: Unique genetic insights from combining isolated population and national health register data

Autor: Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson, Kati Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Päivi Laiho, Pietro Della Briotta Parolo, Arto Lehisto, Masahiro Kanai, Nina Mars, Joel Rämö, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rüeger, Susanna Lemmelä, Wei Zhou, Sanni Ruotsalainen, Kalle Pärn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Katriina Aalto-Setälä, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Färkkilä, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric Green, Antti Hakanen, Marco Hautalahti, Åsa Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kähönen, Risto M. Kajanne, Lila Kallio, Reetta Kälviäinen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpeläinen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Mägi, Johanna Mäkelä, Antti Mäkitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar V. Mozaffari, Mari EK. Niemi, Marianna Niemi, Teemu Niiranen, Christopher J. O’Donnell, Ma’en Obeidat, George Okafo, Hanna M. Ollila, Antti Palomäki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slavé Petrovski, Anne Pitkäranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae H. Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tõnu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi Mäkelä, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie

Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles in any gene is often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::935b1348ad5077383c2beaa56949f6d5
https://doi.org/10.1101/2022.03.03.22271360

No Association between Genetic Loci near IRF2 and TBX1 and Acute Kidney Injury in the Critically Ill

Autor: Laura M. Vilander, Harold Snieder, Ville Pettilä, Frederik Keus, Suvi T. Vaara, Iris J. E. Renken, Mari A. Kaunisto, Iwan C. C. van der Horst

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 201(1), 109-111. AMER THORACIC SOC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ac5792210939fc3a0c1b0bb9ac6576
https://doi.org/10.1164/rccm.201903-0633le

First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2

Autor: Ari Ahola-Olli, Klaus T. Olkkola, Eija Kalso, Ritva Jokela, Sirkku Ahlström, Mari A. Kaunisto, Paula Bergman, Matti Pirinen, Linda Ottensmann

Publikováno v: BJA: British Journal of Anaesthesia

Background Rocuronium, a common neuromuscular blocking agent, is mainly excreted unchanged in urine (10–25%) and bile (>70%). Age, sex, liver blood flow, smoking, medical conditions, and ethnic background can affect its pharmacological actions. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c62e536a6d19d4b98ffcc640e565c31
http://hdl.handle.net/10138/330208