Výsledky vyhledávání - "María Laura Hurtado-León"

Akademický článek

Biophysical Analysis of Potential Inhibitors of SARS-CoV‑2 Cell Recognition and Their Effect on Viral Dynamics in Different Cell Types: A Computational Prediction from In Vitro Experimental Data

Autor: Lenin González-Paz, Carla Lossada, María Laura Hurtado-León, Joan Vera-Villalobos, José L. Paz, Yovani Marrero-Ponce, Felix Martinez-Rios, Ysaías. J. Alvarado

Publikováno v: ACS Omega, Vol 9, Iss 8, Pp 8923-8939 (2024)

Externí odkaz: https://doaj.org/article/08bc1980e1e145faa0560b7a6cf444df

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Macromolecular crowding impact on anti-CRISPR AcrIIC3/NmeCas9 complex: Insights from scaled particle theory, molecular dynamics, and elastic networks models

Autor: Ariana Delgado, Joan Vera-Villalobos, José Luis Paz, Carla Lossada, María Laura Hurtado-León, Yovani Marrero-Ponce, Jhoan Toro-Mendoza, Ysaías J. Alvarado, Lenin González-Paz

Publikováno v: International Journal of Biological Macromolecules. :125113

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::682d21a46a20b08e7dbfaf189e1f9774
https://doi.org/10.1016/j.ijbiomac.2023.125113

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Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT

Autor: Ysaias José Alvarado, Yosmari Olivarez, Carla Lossada, Joan Vera-Villalobos, José Luis Paz, Eddy Vera, Marcos Loroño, Alejandro Vivas, Fernando Javier Torres, Laura N. Jeffreys, María Laura Hurtado-León, Lenin González-Paz

Publikováno v: Computational biology and chemistry. 99

The COVID-19 pandemic has accelerated the study of drugs, most notably ivermectin and more recently Paxlovid (PF-07321332) which is in phase III clinical trials with experimental data showing covalent binding to the viral protease M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04631d26c3d5a6dabd1e3557de3fa188
https://pubmed.ncbi.nlm.nih.gov/35640480

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Theoretical Efficacy of Possible Inhibitors of SARS-CoV-2 Cell Recognition and Their Effect on Viral Dynamics in Different Cell Types: Computational Biology and Prediction from in Vitro Experimental Data

Autor: Lenin González, Carla Lossada, María Laura Hurtado-León, Francelys V. Fernández-Materán, Edgar Portillo, Joan Vera-Villalobos, Marcos Loroño, J. L. Paz, Laura N. Jeffreys, María Dolores Fernández, Ysaias J. Alvarado

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c52af4717ca04bd441af160f12c85a1f
https://doi.org/10.2139/ssrn.4066277

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Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach

Autor: Laura Jeffreys, José Luis Paz, Carla A. Lossada, Marcos Loroño, Ysaias J. Alvarado, María Laura Hurtado-León, Francelys V. Fernández-Materán, Joan Vera-Villalobos, Lenin A. González-Paz

Publikováno v: Biophysical Chemistry

The SARS-CoV-2 pandemic has accelerated the study of existing drugs. The mixture of homologs called ivermectin (avermectin-B1a [HB1a] + avermectin-B1b [HB1b]) has shown antiviral activity against SARS-CoV-2 in vitro. However, there are few reports on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec3bbbb312d72e14bcf0912fe0411aa
https://pubmed.ncbi.nlm.nih.gov/34428682

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Structural deformability induced in proteins of potential interest associated with COVID-19 by binding of homologues present in ivermectin: Comparative study based in elastic networks models

Autor: María Laura Hurtado-León, Ysaias Alvarado, Francelys V. Fernández-Materán, Joan Vera-Villalobos, Marcos Loroño, José Luis Paz, Carla A. Lossada, Laura Jeffreys, Lenin A. González-Paz

Publikováno v: Journal of Molecular Liquids

The COVID-19 pandemic has accelerated the study of the potential of multi-target drugs (MTDs). The mixture of homologues called ivermectin (avermectin-B1a + avermectin-B1b) has been shown to be a MTD with potential antiviral activity against SARS-CoV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def1057e6f4bc9d940f37d55f970bb7d
https://pubmed.ncbi.nlm.nih.gov/34421159

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Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors

Autor: Lenin González-Paz, María José Alvarado, María Laura Hurtado-León, Carla Lossada, Joan Vera-Villalobos, Marcos Loroño, J.L. Paz, Laura N. Jeffreys, F. Javier Torres, Ysaias J. Alvarado

Publikováno v: Computers in Biology and Medicine

Cellular susceptibility to SARS-CoV-2 infection in the respiratory tract has been associated with the ability of the virus to interact with potential receptors on the host membrane. We have modeled viral dynamics by simulating various cellular system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73968755d1415238f786cb63427872b4
https://doi.org/10.1016/j.compbiomed.2022.105245

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Akademický článek

Intrinsic Dynamics of the ClpXP Proteolytic Machine Using Elastic Network Models

Autor: Lenin González-Paz, Carla Lossada, Maria Laura Hurtado-León, Francelys V. Fernández-Materán, José Luis Paz, Shayan Parvizi, Rafael Eduardo Cardenas Castillo, Freddy Romero, Ysaias J. Alvarado

Publikováno v: ACS Omega, Vol 8, Iss 8, Pp 7302-7318 (2023)

Externí odkaz: https://doaj.org/article/fa9c93c803594113b1894ace9381a39c

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