Zobrazeno 1 - 10
of 213
pro vyhledávání: '"María Isabel Loza"'
Autor:
Clément Anfray, Carmen Fernández Varela, Aldo Ummarino, Akihiro Maeda, Marina Sironi, Sara Gandoy, Jose Brea, María Isabel Loza, Sergio León, Alfonso Calvo, Juan Correa, Eduardo Fernandez-Megia, María José Alonso, Paola Allavena, José Crecente-Campo, Fernando Torres Andón
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundIn the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R8
Externí odkaz:
https://doaj.org/article/6cca62f205fd47608a66754ddd717c91
Autor:
Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Rebecca L. McIntyre, Jose Luis Lopez-Aceituno, Álvaro Ballesteros-Gonzalez, Andrea Tapia-Gonzalez, David Fabregat-Safont, Tobias Eisenberg, Jesús Gomez, Adrian Plaza, Aranzazu Sierra-Ramirez, Manuel Perez, David Villanueva-Bermejo, Tiziana Fornari, María Isabel Loza, Gonzalo Herradon, Sebastian J. Hofer, Christoph Magnes, Frank Madeo, Janet S. Duerr, Oscar J. Pozo, Maximo-Ibo Galindo, Isabel del Pino, Riekelt H. Houtkooper, Diego Megias, Jose Viña, Mari Carmen Gomez-Cabrera, Pablo J. Fernandez-Marcos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of th
Externí odkaz:
https://doaj.org/article/f7d4bdf00f4649429a819ba9e54edc06
Autor:
Claudia Gioé-Gallo, Sandra Ortigueira, José Brea, Iu Raïch, Jhonny Azuaje, M. Rita Paleo, Maria Majellaro, María Isabel Loza, Cristian O. Salas, Xerardo García-Mera, Gemma Navarro, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114934- (2023)
Synthetic cannabinoid receptor agonists (SCRAs) constitute the largest and most defiant group of abuse designer drugs. These new psychoactive substances (NPS), developed as unregulated alternatives to cannabis, have potent cannabimimetic effects and
Externí odkaz:
https://doaj.org/article/3b0ddeb6be494b4382e24224b8f69591
Publikováno v:
Molecules, Vol 28, Iss 24, p 8107 (2023)
The identification of new modulators for Cannabinoid Receptors (CBRs) has garnered significant attention in drug discovery over recent years, owing to their manifold pathophysiological implications. In the context of hit identification, the availabil
Externí odkaz:
https://doaj.org/article/b984db540fcc45b38c1ff849fd3cbb3b
Autor:
Antón L. Martínez, José Brea, Eduardo Domínguez, María J. Varela, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño, Ángel Carracedo, María Isabel Loza
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Neuronal differentiation is a complex process through which newborn neurons acquire the morphology of mature neurons and become excitable. We employed a combination of functional and transcriptomic approaches to deconvolute and identify key regulator
Externí odkaz:
https://doaj.org/article/3c8415000e0a492abd7a07ba0e186a39
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1353 (2022)
Based on previously highlighted structural features, the development of highly selective 5-HT1A receptor inhibitors is closely linked to the incorporation of a 4-alkyl-1-arylpiperazine scaffold on them. In this paper, we present the synthesis of two
Externí odkaz:
https://doaj.org/article/23ec3aa23c124227a9b01ba00f1a9875
Autor:
Thirumal Yempala, José Brea, María Isabel Loza, Douglas J. Matthies, Gerald Zapata-Torres, Bruce K. Cassels
Publikováno v:
ACS Omega, Vol 5, Iss 5, Pp 2260-2266 (2020)
Externí odkaz:
https://doaj.org/article/580e3768accb4d9ba7508b7456f331c1
Publikováno v:
Molecules, Vol 27, Iss 23, p 8115 (2022)
Nowadays, cancer disease seems to be the second most common cause of death worldwide. Molecular hybridization is a drug design strategy that has provided promising results against multifactorial diseases, including cancer. In this work, two series of
Externí odkaz:
https://doaj.org/article/fe001ddc423e4e8485d77494722349b8
Autor:
Carolina Herrero, Jose Brea, Amparo Pérez-Díaz, Emiliano Cuadrado, Noelia Ferreño, Cristian Pablo Moiola, Eva Colás, Antonio Gil-Moreno, Rafael López-López, María Isabel Loza, Miguel Abal, Lorena Alonso-Alconada
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111744- (2021)
Endometrial cancer (EC) is the most common neoplasm of the female reproductive tract in the developed world. Patients usually are diagnosed in early stage having a good prognosis. However, up to 20–25% of patients are diagnosed in advanced stages a
Externí odkaz:
https://doaj.org/article/43087a71dee8471a837aec833e1518e2
Autor:
Andrea Bagán, José A. Morales-García, Christian Griñán-Ferré, Caridad Díaz, José Pérez del Palacio, Maria C. Ramos, Francisca Vicente, Belén Pérez, José Brea, María Isabel Loza, Mercè Pallàs, Carmen Escolano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5408 (2022)
The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind due to their vast prevalence and the lack of efficacious treatments. In this scenario, we focused on imidazoline I2 receptors (I2-IR) that are widely distributed in th
Externí odkaz:
https://doaj.org/article/23e5cfa47c79414eb18f2f525aa63824