Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mariëtte van der Watt"'
Autor:
Marianna Stampolaki, Satish Malwal, Nadine Alvarez, Zijun Gao, Mohammad Moniruzzaman, Svitlana Babii, Nikolaos Naziris, André Rey-Cibati, Mariana Valladares-Delgado, Andreea Turcu, Kyung-Hwa Baek, Hyeryon Lee, Matthéo Alcaraz, Savannah Watson, Mariëtte van der Watt, Dina Coertzen, Natasa Efstathiou, Ioannis Stylianakis, Maria Chountoulesi, Carolyn Schoen, Ioannis Papanastasiou, José Brea, Michael Cynamon, Lyn-Marie Birkholtz, Laurent Kremer, Joo Hwan No, Santiago Vazquez, Gustavo Benaim, Costas Demetzos, Helen Zgurskaya, Thomas Dick, Eric Oldfield, Antonios Kolocouris
SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by inhibiting the MmpL3 transporter. It also has activity against bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9134204720e18151a5bb4fe61122aae7
https://doi.org/10.26434/chemrxiv-2022-xm94p
https://doi.org/10.26434/chemrxiv-2022-xm94p
Autor:
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale
Publikováno v:
Science Translational Medicine. 14
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and i
Autor:
Lauren B, Arendse, James M, Murithi, Tarrick, Qahash, Charisse Flerida A, Pasaje, Luiz C, Godoy, Sumanta, Dey, Liezl, Gibhard, Sonja, Ghidelli-Disse, Gerard, Drewes, Marcus, Bantscheff, Maria J, Lafuente-Monasterio, Stephen, Fienberg, Lynn, Wambua, Samuel, Gachuhi, Dina, Coertzen, Mariëtte, van der Watt, Janette, Reader, Ayesha S, Aswat, Erica, Erlank, Nelius, Venter, Nimisha, Mittal, Madeline R, Luth, Sabine, Ottilie, Elizabeth A, Winzeler, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Jacquin C, Niles, Manuel, Llinás, David A, Fidock, Kelly, Chibale
Publikováno v:
Science translational medicine. 14(667)
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human "mammalian target of rapamycin" (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and in vi
Autor:
Janette Reader, Kelly Chibale, Mariëtte van der Watt, Lyn-Marie Birkholtz, Henrico Langeveld, Peter Mubanga Cheuka, Godwin Akpeko Dziwornu, Dina Coertzen, Meta Leshabane
Publikováno v:
Transactions of the Royal Society of South Africa. 76:225-233
Autor:
Lyn-Marie Birkholtz, Dickson Mambwe, Dina Coertzen, Janette Reader, Dale Taylor, Malkeet Kumar, Mariëtte van der Watt, Kelly Chibale, Richard Ferger, Mathew Njoroge
Publikováno v:
ACS Med Chem Lett
[Image: see text] In the context of drug repositioning and expanding the existing structure–activity relationship around astemizole (AST), a new series of analogues were designed, synthesized, and evaluated for their antiplasmodium activity. Among
Autor:
Constance M. Korkor, Kelly Chibale, Godwin Akpeko Dziwornu, Sergio Wittlin, Dina Coertzen, Cleavon K Cloete, Meta Leshabane, Mathew Njoroge, Janette Reader, Nina Lawrence, Lyn-Marie Birkholtz, Liezl Gibhard, Mariëtte van der Watt
Publikováno v:
Journal of Medicinal Chemistry. 64:5198-5215
A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure-activity relationship studies revealed
Autor:
Mariëtte van der Watt, Richard Ferger, Consolata Nsanzubuhoro, Kelly Chisanga, Dina Coertzen, Meta Leshabane, Erica Erlank, Kelly Chibale, Phanankosi Moyo, Godwin Akpeko Dziwornu, Lyn-Marie Birkholtz, Nelius Venter, Lizette L. Koekemoer, Janette Reader
Publikováno v:
ACS Infectious Diseases. 7:1945-1955
The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are needed to treat patients and ha
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Autor:
Sergio Wittlin, Lynn Wambua, Luyanda Centani, Lauren B. Arendse, Lyn-Marie Birkholtz, Dale Taylor, Kelly Chibale, Janette Reader, Dina Coertzen, Nina Lawrence, Malkeet Kumar, Shoneeze S Renga, Peter Mubanga Cheuka, Stephen Fienberg, Godwin Akpeko Dziwornu, Mariëtte van der Watt
Publikováno v:
ACS Infectious Diseases. 7:34-46
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
Autor:
William Shamburger, Gerhard Bringmann, Timothy J. Egan, Janette Reader, Vinesh Maharaj, Lyn-Marie Birkholtz, Mariëtte van der Watt, Phanankosi Moyo, Ana Carolina C. de Sousa
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 51-58 (2020)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validatio