Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mariët Ouwehand"'
Autor:
Hilde Rosing, Mariët Ouwehand, Suzanne V. Frankfort, Maria J. van Maanen, Linda R. Tulner, Jos H. Beijnen
Publikováno v:
Rapid Communications in Mass Spectrometry. 20:3330-3336
A sensitive and specific high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the determination of rivastigmine and its major metabolite NAP 226-90 is presented. A 100 microL plasma aliquot was spiked with a structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0307f0bee79eb73e27dcc781c92b78b8
https://doi.org/10.1002/rcm.2737
https://doi.org/10.1002/rcm.2737
Autor:
Olaf van Tellingen, Jos H. Beijnen, Jan H.M. Schellens, Heleen A. Bardelmeijer, Mariët Ouwehand
Publikováno v:
Investigational New Drugs. 22:219-229
P-glycoprotein inhibitors can increase the oral bioavailability of paclitaxel. We have now explored the mechanisms that determine the efficacy of several novel P-glycoprotein inhibitors to increase the absorption of paclitaxel from the gut lumen of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4deb4670b795f2370ab0f059a95d88be
https://doi.org/10.1023/b:drug.0000026248.45084.21
https://doi.org/10.1023/b:drug.0000026248.45084.21
Autor:
Mariët Ouwehand, O. van Tellingen, Heleen A. Bardelmeijer, Jos H. Beijnen, Jan H.M. Schellens, Tessa Buckle
Publikováno v:
Laboratory Animals. 37:181-187
We have developed and validated a method that allows serial drawing of blood samples in freely moving mice using a cannula that is inserted via the jugular vein into the right atrium of the heart. The cannula was tunnelled subcutaneously to the head
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96da34d9bacfc457c7e3c15cd29bc2fe
https://doi.org/10.1258/002367703766453010
https://doi.org/10.1258/002367703766453010
Autor:
Olaf van Tellingen, Mariët Ouwehand, Heleen A. Bardelmeijer, Mirte M. Malingré, Jan H.M. Schellens, Jos H. Beijnen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 49:119-125
Background: Recent studies in mice and patients have shown that the low oral bioavailability of paclitaxel can be increased by coadministration of P-glycoprotein blockers. However, in patients an increase in the oral paclitaxel dose from 60 to 300 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f591e561180652725a76716573134d
https://doi.org/10.1007/s00280-001-0394-2
https://doi.org/10.1007/s00280-001-0394-2
Autor:
Mariët Ouwehand, Olaf van Tellingen, Jan H.M. Schellens, Jos H. Beijnen, Heleen A. Bardelmeijer
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 763:201-206
An isocratic reversed-phase high-performance liquid chromatographic method with ultraviolet detection at 227 nm has been validated for the determination of cyclosporin A in human and mouse plasma. The cyclosporin D analog PSC 833 was used as internal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a460e8c4e08b2ad715e418afc5ec3b1a
https://doi.org/10.1016/s0378-4347(01)00389-9
https://doi.org/10.1016/s0378-4347(01)00389-9
Autor:
Hilde Rosing, Jan H.M. Schellens, W.W. ten Bokkel Huinink, Mirte M. Malingré, Heleen A. Bardelmeijer, Koopman Fj, Jos H. Beijnen, Margaret Schot, O. van Tellingen, Mariët Ouwehand
Publikováno v:
British Journal of Cancer
The purpose of this study was to investigate the effect of the co-solvents Cremophor EL and polysorbate 80 on the absorption of orally administered paclitaxel. 6 patients received in a randomized setting, one week apart oral paclitaxel 60 mg m−2 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365fe26f965ec5f5a55ae27e8f97737f
https://doi.org/10.1054/bjoc.2001.2118
https://doi.org/10.1054/bjoc.2001.2118
Autor:
Mariët Ouwehand, Heleen A. Bardelmeijer, Olaf van Tellingen, Tessa Buckle, Jos H. Beijnen, Jan H.M. Schellens
Publikováno v:
Laboratory Animals. 39:130-132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c026472f3243328de677f3c2a8d17071
https://doi.org/10.1258/0023677052886466
https://doi.org/10.1258/0023677052886466
Publikováno v:
Biomedical chromatography : BMC. 21(11)
A sensitive and selective reversed-phase high-performance liquid chromatographic (HPLC) assay has been developed and validated for quantification of total topotecan in human and mouse plasma and in mouse tissue samples. Isocratic separation was achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbe702dfa8b790f85c0524b3d09f721
https://pubmed.ncbi.nlm.nih.gov/17582233
https://pubmed.ncbi.nlm.nih.gov/17582233
Autor:
Jan-Hendrik Beumer, Luis Lopez-Lazaro, Niels E. F. Franke, Tessa Buckle, Mariët Ouwehand, Olaf van Tellingen, Jos H. Beijnen, Jan H.M. Schellens
Publikováno v:
Investigational new drugs. 25(1)
Trabectedin (ET-743, Yondelis™) is a novel anticancer drug currently undergoing phase II and III investigations. There are various and conflicting reports whether trabectedin is a substrate for P-glycoprotein (P-gp), an important factor in drug dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef1fa700c4fe1d92e51418012982087
https://pubmed.ncbi.nlm.nih.gov/16633714
https://pubmed.ncbi.nlm.nih.gov/16633714
Autor:
Lianda Nan, O. van Tellingen, E. M. Kemper, Mariët Ouwehand, Hilde Rosing, E. Stokvis, Jos H. Beijnen
Publikováno v:
Journal of mass spectrometry : JMS. 39(12)
The development and validation of an assay for the determination of paclitaxel in human plasma, human brain tumor tissue, mouse plasma and mouse brain tumor tissue is described. Paclitaxel was extracted from the matrices using liquid-liquid extractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bc67c915d9ca540badc200f29a95a3
https://pubmed.ncbi.nlm.nih.gov/15578748
https://pubmed.ncbi.nlm.nih.gov/15578748